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Study provides new insights into early events that shape cancer

A study led by researchers from Brigham and Women's Hospital suggests a new way to trace cancer back to its cell type of origin. By leveraging the epigenome maps produced by the Roadmap Epigenomics Program - a resource of data collected from over 100 cell types - the research team found that the unique genetic landscape of a particular tumor could be used to predict that tumor's cell type of origin.

19 Feb 2015

UT Dallas study reports new gene therapy approach

Bioengineers at The University of Texas at Dallas have created a novel gene-delivery system that shuttles a gene into a cell, but only for a temporary stay, providing a potential new gene-therapy strategy for treating disease.

19 Feb 2015

Study findings could lead to new potential drug targets for allergic diseases

Scientists have discovered over 30 new genes that predispose people to allergies and asthma, some of which could be targets for new drugs.

19 Feb 2015

Duke researchers demonstrate genetic therapeutic technique to treat DMD patients

Duke researchers have demonstrated a genetic therapeutic technique that has the potential to treat more than half of the patients suffering from Duchenne Muscular Dystrophy (DMD).

19 Feb 2015

Researchers assemble comprehensive map of human epigenome

Virtually every cell in the body carries an identical genome. But how is it possible that each of the body's 200 different types of specialized cells - in the heart, brain, bone, skin and elsewhere - develops from the same DNA instruction book?

19 Feb 2015

Scientists map autism genetic pathway that regulates brain development

Scientists at the University of California, San Diego School of Medicine have found that mutations that cause autism in children are connected to a pathway that regulates brain development. The research, led by Lilia Iakoucheva, PhD, assistant professor in the Department of Psychiatry, is published in the February 18 issue of Neuron.

19 Feb 2015

Epigenome may hold promise for conquering diseases

The human genome project captured the public imagination when its first draft was published 14 years ago this week in the international science journal Nature, but the epigenome may hold the real promise for conquering disease.

19 Feb 2015

New facts provide baseline for future studies of epigenome's role in human development, diseases

While genomics is the study of all of the genes in a cell or organism, epigenomics is the study of all the genomic add-ons and changes that influence gene expression but aren't encoded in the DNA sequence. A variety of new epigenomic information is now available in a collection of studies published Feb. 19 in Nature by the National Institutes of Health Roadmap Epigenomics Program.

19 Feb 2015

First comprehensive maps and analyses of human epigenomes revealed

Two dozen scientific papers published online simultaneously on Feb. 18, 2015 present the first comprehensive maps and analyses of the epigenomes of a wide array of human cell and tissue types. Epigenomes are patterns of chemical annotations to the genome that determine whether, how, and when genes are activated.

18 Feb 2015

Sigma-Aldrich announces release of Next-Gen Sequencing Oligos

Sigma-Aldrich Corporation today announced that Sigma Life Science, its innovative biological products and services business, released Next-Gen Sequencing Oligos, custom next-generation sequencing adapters that improve target sequence assembly.

18 Feb 2015

Researchers show importance of DNA damage in fine tuning of innate immune system

For the first time scientists from Umeå University show the importance of DNA damage in fine tuning of our innate immune system and hence the ability to mount the optimal inflammatory response to infections and other biological dangers.

18 Feb 2015

Scientists identify role of tau-associated MAPT gene in development of Alzheimer's disease

An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, has identified the microtubule-associated protein tau (MAPT) gene as increasing the risk for developing Alzheimer's disease (AD).

18 Feb 2015

Study shows link between autoimmune diseases and gene regulatory elements

Investigators with the National Institutes of Health have discovered the genomic switches of a blood cell key to regulating the human immune system.

17 Feb 2015

Scientists demonstrate the importance of RNA editing in melanoma development

The importance of RNA editing in melanoma has been demonstrated by scientists at The University of Texas MD Anderson Cancer Center. The study revealed that a lack of RNA editing, a process by which information inside RNA molecules is transformed, leads to tumor growth and progression through manipulation of proteins.

17 Feb 2015

Research: Complex nerve circuits first evolved in common ancestor of humans and cnidarians

New research shows that a burst of evolutionary innovation in the genes responsible for electrical communication among nerve cells in our brains occurred over 600 million years ago in a common ancestor of humans and the sea anemone.

17 Feb 2015

Study shows that de novo mutations can be detected in human in vitro fertilized embryos using PGD

Reprogenetics, the largest U.S. genetics laboratory specializing in Preimplantation Genetic Diagnosis (PGD), announced today the publication of new clinical data in the March issue of Genome Research demonstrating that de novo single base mutations can be detected in embryos after in vitro fertilization (IVF).

16 Feb 2015

A*STAR's GIS scientists develop new system that can predict treatment targets for cancer

In recent months, several national initiatives for personalized medicine have been announced, including the recently launched precision medicine initiative in the US, driven by rapid advances in genomic technologies and with the promise of cheaper and better healthcare. Significant challenges remain, however, in the management and analysis of genetic information and their integration with patient data.

15 Feb 2015

New study indicates that malaria-causing parasite is unlikely to cross from animals to humans

In recent years, public health experts have increasingly explored the idea of eliminating the most dangerous malaria-causing parasite. But they have questioned whether getting rid of this species, called Plasmodium falciparum, would allow other species of the parasite to simply jump into the gap and start infecting humans with malaria.

13 Feb 2015

SIB Swiss Institute of Bioinformatics designated as FAO Reference Centre for bioinformatics

The Food and Agriculture Organization of the United Nations (FAO) has appointed SIB Swiss Institute of Bioinformatics as the FAO Reference Centre for bioinformatics.

12 Feb 2015

Researchers identify molecular pathways associated with distinct subsets of SSc patients

For years, doctors have been baffled about why some patients with systemic sclerosis (SSc) respond to therapy while others do not.

12 Feb 2015

Genome News and Research

Study provides new insights into early events that shape cancer

UT Dallas study reports new gene therapy approach

Study findings could lead to new potential drug targets for allergic diseases

Duke researchers demonstrate genetic therapeutic technique to treat DMD patients

Researchers assemble comprehensive map of human epigenome

Scientists map autism genetic pathway that regulates brain development

Epigenome may hold promise for conquering diseases

New facts provide baseline for future studies of epigenome's role in human development, diseases

First comprehensive maps and analyses of human epigenomes revealed

Sigma-Aldrich announces release of Next-Gen Sequencing Oligos

Researchers show importance of DNA damage in fine tuning of innate immune system

Scientists identify role of tau-associated MAPT gene in development of Alzheimer's disease

Study shows link between autoimmune diseases and gene regulatory elements

Scientists demonstrate the importance of RNA editing in melanoma development

Research: Complex nerve circuits first evolved in common ancestor of humans and cnidarians

Study shows that de novo mutations can be detected in human in vitro fertilized embryos using PGD

A*STAR's GIS scientists develop new system that can predict treatment targets for cancer

New study indicates that malaria-causing parasite is unlikely to cross from animals to humans

SIB Swiss Institute of Bioinformatics designated as FAO Reference Centre for bioinformatics

Researchers identify molecular pathways associated with distinct subsets of SSc patients

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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