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Retransplantation may provide better survival over dialysis after failed first kidney transplant

Kidney transplantation is the preferred therapy after kidney failure, but kidneys transplanted from deceased donors often do not last for the rest of a recipient's life.

28 Dec 2021

Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene

Using a short, synthetic chain of chemically modified nucleotides engineered in the RNA Therapeutics Institute at UMass Chan Medical School, Robert H. Brown Jr., DPhil, MD, Jonathan Watts, PhD, and colleagues have shown the ability to suppress mutant forms of an ALS gene known as C9ORF72 in a single-patient pilot study.

24 Dec 2021

High-fiber diet helps melanoma patients to respond better to immunotherapy

Melanoma patients receiving therapy that makes it easier for their immune system to kill cancer cells respond to treatment better when their diet is rich in fiber, according to a large, international research collaboration that includes the Oregon State University College of Pharmacy.

24 Dec 2021

Inhaled CBD shrinks glioblastoma’s size in an animal model

Inhaled CBD shrinks the size of the highly aggressive, lethal brain tumor glioblastoma in an animal model by reducing the essential support of its microenvironment, researchers report.

24 Dec 2021

High-fiber diet linked with improved survival and response to immunotherapy in melanoma patients

Dietary fiber and probiotics impact gut bacteria and immunotherapy responses in melanoma patients, a new study in patients shows.

24 Dec 2021

Impact of COVID-19 pandemic on sleep behavior, emotional stability of people with previous pathologies

Selene Valero and José Gil, researchers at the Faculty of Psychology and Speech Therapy of the University of Valencia, have studied the changes in sleep behaviour and emotional stability of healthy patients and with previous pathologies before and after the COVID-19 pandemic.

23 Dec 2021

Fiber-rich diet may help some melanoma patients to respond to immunotherapy

A diet rich in fiber may help some people being treated for melanoma respond to immunotherapy treatment by influencing the gut microbiome, according to a new study led by researchers at the Center for Cancer Research at the National Cancer Institute, part of the National Institutes of Health, and the University of Texas MD Anderson Cancer Center.

23 Dec 2021

Mapping access to HIV care

In this interview, we speak to Professor Diego Cuadros about his latest research in which he mapped individuals' access to HIV care in Africa.

23 Dec 2021

Researchers receive NIH grants to develop new treatments for neglected tropical diseases

Researchers at Washington University School of Medicine in St. Louis have received two grants from the National Institutes of Health totaling more than $5.5 million to develop new treatments for two types of devastating parasitic infections common in sub-Saharan Africa and Central and South America: river blindness and intestinal worm infections.

22 Dec 2021

Amino acid valine plays a key role in the growth of T cell acute lymphoblastic leukemia

A molecular building block of many animal proteins, the amino acid valine, plays a key role in cancerous growth seen in T cell acute lymphoblastic leukemia, a new study shows.

22 Dec 2021

Study suggests nitazoxanide fails to reduce the severity of SARS-CoV-2

A new study shows that the optimization of nitazoxanide formulations may allow the review of the potential use of the drug for the treatment of SARS-CoV-2 infection.

22 Dec 2021

Researchers identify new mechanism for DNA invasion of adenoviral COVID-19 vaccines

Adenoviruses have a linchpin protein that stabilizes their DNA until it reaches the infected cell's nucleus. The protein then detaches from the viral genome, and the virus uncoats. Only then are the genes released into the nucleus, which is necessary for the production of new viruses.

22 Dec 2021

Researchers use network modeling to hone in on cancer gene interactions critical to malignancy

Wilmot Cancer Institute researchers are a step closer to understanding the complex gene interactions that cause a cell to become malignant.

21 Dec 2021

Early administration of SARS-CoV-2 convalescent plasma reduces outpatient hospitalizations

The results of a nationwide, multicenter clinical trial led by Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health provides solid evidence for the use of plasma from convalescent patients — those who have recovered from the disease and whose blood contains antibodies against SARS-CoV-2, the virus that causes COVID-19 — as an early treatment.

21 Dec 2021

Younger cancer patients at particularly increased risk of mortality from COVID-19

Systematic reviews and meta-analysis were conducted to identify the impact of SARS-CoV-2 in cancer patients based on tumor type, age, and treatment, and any novel risk factors for COVID-19 in cancer patients

21 Dec 2021

Study reveals how gut bacteria can impact the course of neurological diseases

A New York-based, multi-institutional research team has found high levels of three toxic metabolites produced by gut bacteria in the cerebrospinal fluid and plasma samples of multiple sclerosis (MS) patients.

21 Dec 2021

Crash course: Injured patients who sign ‘letters of protection’ may face huge medical bills and risks

Jean Louis-Charles couldn't afford spine surgery to ease nagging neck and back pain after a car crash. So he signed a document, promising to pay the bill with money he hoped to get from a lawsuit against the driver who caused the collision.

21 Dec 2021

$Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma$

Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma

Early results from an Alliance for Clinical Trials in Oncology randomized clinical trial of adults with multiple myeloma relapsing on frontline lenalidomide therapy showed that adding ixazomib (Ninlaro®) to pomalidomide and dexamethasone as part of second line therapy extended the length of time patients lived before their disease worsened (progression-free survival) compared with patients who received pomalidomide and dexamethasone.

21 Dec 2021

Study casts light on how to combine antibiotics and phage therapy to fight bacterial infection

New research has moved a step closer to harnessing viruses to fight bacterial infection, reducing the threat of antibiotic resistance.

20 Dec 2021

Nanostructured polymeric scaffolds accelerate neuronal differentiation of neural stem cells

Collaboration between different UPV/EHU departments has achieved a promising advance for future cell therapy: nanostructured scaffolds based on bioresorbable polymers and graphene derivatives that induce aligned migration and accelerate the neuronal differentiation of neural stem cells.

20 Dec 2021

Therapy News and Research

Retransplantation may provide better survival over dialysis after failed first kidney transplant

Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene

High-fiber diet helps melanoma patients to respond better to immunotherapy

Inhaled CBD shrinks glioblastoma’s size in an animal model

High-fiber diet linked with improved survival and response to immunotherapy in melanoma patients

Impact of COVID-19 pandemic on sleep behavior, emotional stability of people with previous pathologies

Fiber-rich diet may help some melanoma patients to respond to immunotherapy

Mapping access to HIV care

Researchers receive NIH grants to develop new treatments for neglected tropical diseases

Amino acid valine plays a key role in the growth of T cell acute lymphoblastic leukemia

Study suggests nitazoxanide fails to reduce the severity of SARS-CoV-2

Researchers identify new mechanism for DNA invasion of adenoviral COVID-19 vaccines

Researchers use network modeling to hone in on cancer gene interactions critical to malignancy

Early administration of SARS-CoV-2 convalescent plasma reduces outpatient hospitalizations

Younger cancer patients at particularly increased risk of mortality from COVID-19

Study reveals how gut bacteria can impact the course of neurological diseases

Crash course: Injured patients who sign ‘letters of protection’ may face huge medical bills and risks

Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma

Study casts light on how to combine antibiotics and phage therapy to fight bacterial infection

Nanostructured polymeric scaffolds accelerate neuronal differentiation of neural stem cells

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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