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Pyroptosis found to promote wound healing and tissue repair

A study by the team of Prof. Kodi Ravichandran (VIB-UGent Center for Inflammation Research) and colleagues found that pyroptosis, a form of programmed cell death traditionally thought to be purely inflammatory, also plays a crucial role in promoting healing and tissue repair.

11 Sep 2024

COVID-19 mRNA vaccine linked to myocardial scarring in adolescents and young adults

The study investigates COVID-19 vaccine-related myocarditis in adolescents, revealing clinical characteristics and risks of myocardial injury in young adults.

11 Sep 2024

Study reveals population-wide immune setpoint for SARS-CoV-2 antibodies

Researchers discovered that SARS-CoV-2 antibody levels in the Dominican Republic converge to a population-wide immune setpoint, regardless of individual vaccination or infection history.

10 Sep 2024

New chemical modification reduces off-target effects in siRNA drugs

Small interfering RNA (siRNA) drugs are a class of therapeutic agents that silence specific genes associated with inherited diseases.

9 Sep 2024

Cannabidiol shown to extend lifespan and improve symptoms in Leigh syndrome models

A study led by the UAB Institut de Neurociències and published in the journal Nature Communications demonstrates in animal models how daily administration of cannabidiol (CBD), a substance obtained from the cannabis plant, extends lifespan and improves symptoms associated with Leigh syndrome.

6 Sep 2024

Arthritis medications could reverse COVID lung damage

Arthritis drugs already available for prescription have the potential to halt lingering lung problems that can last months or years after COVID-19 infections, new research from the University of Virginia School of Medicine and Cedars-Sinai suggests.

6 Sep 2024

Aging immune system fuels cancer growth

A novel study by researchers at the Icahn School of Medicine at Mount Sinai addresses a critical yet under-explored question in cancer research: Why is aging the biggest risk factor for cancer? The study reveals how an aging immune system spurs tumor growth, offering new insights into cancer prevention and treatment, especially for older adults.

6 Sep 2024

Selenium and manganese levels significantly impact mortality risk in asthma patients

Study reveals that both low and high levels of selenium and manganese in the blood are associated with increased mortality in adults with asthma, highlighting the importance of maintaining optimal levels of these metals.

5 Sep 2024

Newly discovered antibody can neutralize all known variants of SARS-CoV-2

Researchers have discovered an antibody able to neutralize all known variants of SARS-CoV-2, the virus that causes COVID-19, as well as distantly related SARS-like coronaviruses that infect other animals.

3 Sep 2024

Intranasal vaccine shows broad SARS-CoV-2 variant protection

Study demonstrates that a single-dose intranasal live-attenuated vaccine, CDO-7N-1, provides broad protection against SARS-CoV-2 and its variants by inducing potent immune responses, including neutralizing antibodies and T-cell activity, in animal models.

1 Sep 2024

New study highlights potential of childhood immunization against HIV

Research at Weill Cornell Medicine suggests that childhood immunization against HIV could one day provide protection before risk of contracting this potentially fatal infection dramatically increases in adolescence.

30 Aug 2024

Rare genetic mutation tied to increased risk of tuberculosis

Tuberculosis is a confounding scourge. It's the leading cause of death from infectious disease in the world, and yet it's estimated that those deaths represent perhaps 5% of infections with Mycobacterium tuberculosis (Mtb).

30 Aug 2024

$Regulatory T cells play a key role in fracture healing and tissue repair$

Regulatory T cells play a key role in fracture healing and tissue repair

The study uncovers a unique reparative function of regulatory T cells (Tregs) in the process of fracture healing, a discovery that adds a new dimension to our understanding of the immune response in tissue regeneration.

29 Aug 2024

Fibrin fuels thromboinflammation and brain damage in COVID-19

Researchers reveal fibrin's critical role in COVID-19 by driving thromboinflammation and neuropathology, and highlight a potential antibody therapy to mitigate these effects.

29 Aug 2024

Studies uncover mechanisms behind micronuclear instability and cancer progression

Reactive oxygen species (ROS) from mitochondria are key drivers of genetic chaos in cancer by causing the collapse of micronuclear envelopes, a process that fuels the chromosomal instability (CIN) often observed in aggressive tumor behavior.

29 Aug 2024

CD4 T cells found to be key players in tuberculosis defense

The body's first line of defense against tuberculosis (TB) involves immune cells that suppress lung inflammation instead of activating it, reported University of Pittsburgh and the Ragon Institute of Mass General, MIT, and Harvard scientists today in Immunity.

29 Aug 2024

Distinct waves of T cells generated by each dose of combination immunotherapy

A new tool for monitoring immune health patterns over time has revealed how a pair of checkpoint inhibitor therapies works together to recruit new cancer-fighting T cells with every infusion.

29 Aug 2024

Study explores link between prostate cancer treatment and Alzheimer’s disease

Researchers at the Medical College of Georgia at Augusta University are searching for a better way to understand why many men with prostate cancer end up with Alzheimer's disease, and whether it's the standard hormone therapy treatment or an overactive immune response that actually contributes to the problem.

29 Aug 2024

New insights into AD pathogenesis and treatment

The main text of the study details the experiments conducted to understand the role of IL-24 in AD-like conditions. It describes the methods used, including single-cell RNA sequencing, and the animal models employed to mimic AD. The findings indicate that MRSA infection leads to increased IL-24 in keratinocytes, which in turn heightens type 2 immune responses and worsens AD symptoms.

29 Aug 2024