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Exploring waning vaccine effectiveness over time

New research provides strong evidence against waning protection against symptomatic disease from both ChAdOx1-S and BNT162b2, but points out that protection against hospitalization and death remains at much higher levels for at least 20 weeks post-vaccination.

14 Jan 2022

Analysis of COVID vaccine breakthrough infections in highly vaccinated Israel

Researchers evaluated and modeled age-structured cases of SARS-CoV-2 infection, SARS-CoV-2 vaccination coverage, and breakthrough infections.

13 Jan 2022

Flu vaccines can be lifesaving for children, study shows

A new CDC study published in the journal Clinical Infectious Diseases (CID) shows that flu vaccination protected children against serious flu illness even when they were infected with a flu virus that was antigenically different from the vaccine virus.

13 Jan 2022

Study finds reductions in hospital admissions for childhood infections during first year of pandemic

During the first year or so of the covid-19 pandemic, there were dramatic reductions in hospital admissions for common and severe childhood infections in England, most likely due to social distancing measures, school and workplace closures, and travel restrictions, finds a study published by The BMJ today.

13 Jan 2022

A clinical tool for monoclonal antibody allocation to treat COVID-19

In this research paper, a group of Mayo Clinic researchers discusses how data from MATRx's clinical prioritizing algorithms can be used to address anti-spike monoclonal antibody allocation during times of scarcity.

13 Jan 2022

An egg-derived SARS-CoV-2 vaccine and treatment for COVID-19 disease

A new study, posted to the medRxiv* preprint server, has focussed on the development of intranasal prophylaxis against SARS-CoV-2 infection.

11 Jan 2022

VarLOCK approach for rapid detection of SARS-CoV-2 variants of concern and wastewater monitoring

A recent study discussed the expansion of the SARS-CoV-2 CRISPR-Cas detection technology (SHERLOCK) into Variant-specific SHERLOCK (VarLOCK) assays to accurately differentiate between the newly emerging SARS-CoV-2 variants of concern.

11 Jan 2022

Study finds heterologous vaccine booster evokes robust immunity to SARS-CoV-2 Omicron variant

The current study examines the role of heterologous vaccination, an area that lacks much clarity.

11 Jan 2022

The effect of COVID-19 on routine immunizations for vaccine-preventable diseases

A new study has focussed on determining the impact of COVID-19 associated interferences with different recovery scenarios for ten vaccine-preventable diseases.

11 Jan 2022

Durability of vaccine protection against COVID-19 breakthrough infections and hospitalizations

In a new study, researchers investigated the duration of protection provided by the coronavirus disease 2019 vaccines available in the United States against breakthrough infections, hospitalizations, and intensive care unit admissions.

10 Jan 2022

History of SARS-CoV-2 infection affects longitudinal responses to BNT162b2 vaccine

In a recently published article in the journal Cell Reports, scientists have demonstrated that individuals with or without a history of coronavirus disease 2019 (COVID-19) exhibit differential humoral and cellular immune responses 14 days after receiving mRNA-based COVID-19 vaccine developed by Pfizer/BioNTech. However, at a later time point, the responses become comparable between the two groups.

9 Jan 2022

Characteristics of initial hospitalization and readmissions among pediatric patients with COVID-19 in the US

Researchers from various institutions describe the characteristics, costs, and healthcare resource use associated with pediatric COVID-19 patients.

7 Jan 2022

Evaluating the response of lung cancer patients to COVID-19 mRNA vaccination

Researchers examine the efficacy of mRNA COVID-19 vaccination in NSCLC patients.

6 Jan 2022

Comparison of neutralization of SARS-CoV-2 variants of concern Omicron and Delta

The purpose of this study was to determine the breadth of neutralizing activity generated by exposure to certain SARS-CoV-2 variants, vaccinations, or both.

6 Jan 2022

Study findings suggest spread of Omicron can be ascribed to immune evasiveness rather than an increase in transmissibility

Researchers investigate the household transmission of the Omicron VOC and increased immune evasiveness of both the Omicron and Delta variants

5 Jan 2022

Oral bacteria-based SARS-CoV-2 vaccine platform

In a new study, researchers engineered the bacterial strain, Salmonella, to express differently-sized antigens to serve as vaccine platforms.

5 Jan 2022

Israeli study confirms drop in BNT162b2 efficacy after six months

Researchers determine whether BNT162b2 vaccination has become less efficient in preventing infection over time.

4 Jan 2022

Study finds pan-sarbecovirus nanobodies can enhance development of super-immunity

A new study found that applying pan-sarbecovirus nanobodies shows a strong affinity toward all sarbecovirus clades and neutralized SARS-CoV-2 receptor binding domains

4 Jan 2022

SARS-CoV-2 spike T cell responses from vaccines or infection remain robust against Omicron

In a new study, a team of researchers from multi-national institutions discovered that 70-80% of CD4 and CD8 T cell responses to spike were consistent across research groups. Moreover, although having far more mutations, the magnitude of Omicron cross-reactive T cells was comparable to that of the Beta and Delta variants.

3 Jan 2022

SARS-CoV-2 Omicron variant highly resistant to vaccine-elicited and therapeutic antibodies

Researchers analyzed convalescent sera and sera from immunized individuals to demonstrate the evasion of antibodies by the SARS-CoV-2 Omicron variant.

3 Jan 2022

Immunization News and Research

Exploring waning vaccine effectiveness over time

Analysis of COVID vaccine breakthrough infections in highly vaccinated Israel

Flu vaccines can be lifesaving for children, study shows

Study finds reductions in hospital admissions for childhood infections during first year of pandemic

A clinical tool for monoclonal antibody allocation to treat COVID-19

An egg-derived SARS-CoV-2 vaccine and treatment for COVID-19 disease

VarLOCK approach for rapid detection of SARS-CoV-2 variants of concern and wastewater monitoring

Study finds heterologous vaccine booster evokes robust immunity to SARS-CoV-2 Omicron variant

The effect of COVID-19 on routine immunizations for vaccine-preventable diseases

Durability of vaccine protection against COVID-19 breakthrough infections and hospitalizations

History of SARS-CoV-2 infection affects longitudinal responses to BNT162b2 vaccine

Characteristics of initial hospitalization and readmissions among pediatric patients with COVID-19 in the US

Evaluating the response of lung cancer patients to COVID-19 mRNA vaccination

Comparison of neutralization of SARS-CoV-2 variants of concern Omicron and Delta

Study findings suggest spread of Omicron can be ascribed to immune evasiveness rather than an increase in transmissibility

Oral bacteria-based SARS-CoV-2 vaccine platform

Israeli study confirms drop in BNT162b2 efficacy after six months

Study finds pan-sarbecovirus nanobodies can enhance development of super-immunity

SARS-CoV-2 spike T cell responses from vaccines or infection remain robust against Omicron

SARS-CoV-2 Omicron variant highly resistant to vaccine-elicited and therapeutic antibodies

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