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New drug combination doubles effectiveness in shrinking enlarged spleens in myelofibrosis patients

Combining the JAK inhibitor ruxolitinib with the BCL-xL inhibitor navitoclax was twice as effective in reducing enlarged spleens – a major indicator of clinical improvement – compared with standard-of-care ruxolitinib monotherapy for adult patients with intermediate or high-risk myelofibrosis, a rare bone marrow cancer, according to results of the Phase III TRANSFORM-1 trial reported by researchers from The University of Texas MD Anderson Cancer Center.

11 Dec 2023

Natural supplements Guayusa tea and Lion’s Mane boost cognitive performance, study finds

Study shows that Guayusa extract and Nordic Lion’s Mane (LM) improve subjective cognitive perception and objective cognitive performance, highlighting their potential benefits in enhancing cognitive functions and mood.

10 Dec 2023

Women undergoing chemotherapy may not benefit from common fertility protection drug

A new study from Karolinska Institutet in Sweden has found no evidence that a common drug used to protect the ovaries of women undergoing chemotherapy increases their chances of having children after cancer treatment.

8 Dec 2023

Anastrozole efficacy in breast cancer prevention for high-risk women linked to estrogen levels

Study examines the efficacy of anastrozole in preventing breast cancer in postmenopausal women at high risk, focusing on the role of baseline estradiol levels and their impact on treatment outcomes.

7 Dec 2023

Paracetamol and ibuprofen equally effective for tension-type headaches, study reveals

A systematic review and meta-analysis in Scientific Reports finds no significant difference between paracetamol and ibuprofen in treating episodic tension-type headaches, suggesting both as viable options for pain relief.

7 Dec 2023

Cocoa extract may benefit cognitive function in older adults with poor diets

Cocoa extract has shown a potential protective effect on cognition but randomized clinical trials in older adults have had inconsistent results.

7 Dec 2023

New early phase study evaluates “on-demand” HIV prevention method for women

A fast-dissolving vaginal insert that women would use at or around the time of sex as an "on-demand" HIV prevention method is being evaluated in a new early phase study being conducted by MATRIX, a United States Agency for International Development (USAID)-funded project focused on the early research and development of innovative HIV prevention products for women.

7 Dec 2023

New drug combo fights breast cancer with brain metastases

A combination of two HER2-targeted drugs, tucatinib (Tukysa) and trastuzumab emtansine (Kadcyla, T-DM1), extended progression-free survival among patients with unresectable locally advanced or metastatic HER2-positive breast cancer, compared with T-DM1 alone, according to results from the HER2CLIMB-02 trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

6 Dec 2023

Photobiomodulation shows promise as safe and tolerable adjunct therapy for Parkinson's Disease, recent trial suggests

A safe and feasible treatment option for reducing the motor signs of Parkinson's disease.

5 Dec 2023

$Vitamin D supplementation fails to prevent fractures in children$

Vitamin D supplementation fails to prevent fractures in children

A major clinical trial led by Queen Mary University of London and the Harvard T.H. Chan School of Public Health has found that vitamin D supplements do not increase bone strength or prevent bone fractures in children with vitamin D deficiency.

1 Dec 2023

Researchers explore the optimal timing, dosage of B-12 supplements during pregnancy and lactation

Babies and children need vitamins, including vitamin B-12, to help their brains and bodies develop and grow.

1 Dec 2023

Herpes zoster vaccination and healthy aging: Study connect the dots

Vaccination with recombinant zoster vaccine (RZV) prevents Herpes Zoster (HZ) infection.

30 Nov 2023

Routine thyroid hormone treatment for organ donors ineffective and potentially harmful

Doctors managing deceased organ donors routinely treat the donors' bodies with thyroid hormones in a bid to preserve heart function and increase the quantity and quality of hearts and other organs available for transplantation.

29 Nov 2023

Abnormally high levels of 'good cholesterol' linked to elevated risk of dementia in older adults

Abnormally high levels of HDL-C, colloquially known as 'good cholesterol', are associated with an increased risk of dementia in older adults, a Monash University-led study has found.

29 Nov 2023

Study finds promising new approach to treating locally advanced pancreatic cancer

A new Phase Ib/II study from researchers at The University of Texas MD Anderson Cancer Center and Moffitt Cancer Center found that combining sensitizing drugs with a specific form of radiation therapy may be more effective in patients with locally advanced pancreatic cancer, yielding a higher progression-free survival (PFS) and overall response rate (ORR).

28 Nov 2023

Exonate announces successful completion of Phase Ib/IIa trial in diabetic macular oedema

Lead ophthalmology candidate EXN407 has potential to be the first topical treatment for diabetic retinopathy/diabetic macular oedema.

28 Nov 2023

Multi-ingredient herbal supplement boosts cognitive speed and gut health in seniors

In a study on elderly patients with subjective memory decline, a 90-day herbal supplement regimen improved cognitive task speed and altered gut microbiota, despite causing memory deficits. This intervention increased urinary tyrosine levels, suggesting a dopaminergic activity role in cognitive enhancements.

26 Nov 2023

The potential of polyunsaturated fatty acids in alleviating depression and reducing suicide risk

Research in 'Molecular Psychiatry' explores the role of long-chain polyunsaturated fatty acids (LC-PUFAs) in major depressive disorder (MDD) and suicide risk, showing mixed results in clinical trials for depression treatment. The study underscores the need for further investigation into LC-PUFAs' neurobiology to advance personalized medicine for mood disorders and suicide prevention.

26 Nov 2023

Reducing cholesterol esters protects the brain against Alzheimer's-like damage

In Alzheimer's disease and related dementias, cognitive decline is driven by the overaccumulation of a normal brain protein known as tau.

22 Nov 2023

Study finds among outpatients with mild to moderate COVID-19, treatment with fluvoxamine does not reduce duration of symptoms

Researchers investigate the effects of high-dose fluvoxamine among patients with mild-to-moderate COVID-19.

22 Nov 2023

Placebo News and Research

New drug combination doubles effectiveness in shrinking enlarged spleens in myelofibrosis patients

Natural supplements Guayusa tea and Lion’s Mane boost cognitive performance, study finds

Women undergoing chemotherapy may not benefit from common fertility protection drug

Anastrozole efficacy in breast cancer prevention for high-risk women linked to estrogen levels

Paracetamol and ibuprofen equally effective for tension-type headaches, study reveals

Cocoa extract may benefit cognitive function in older adults with poor diets

New early phase study evaluates “on-demand” HIV prevention method for women

New drug combo fights breast cancer with brain metastases

Photobiomodulation shows promise as safe and tolerable adjunct therapy for Parkinson's Disease, recent trial suggests

Vitamin D supplementation fails to prevent fractures in children

Researchers explore the optimal timing, dosage of B-12 supplements during pregnancy and lactation

Herpes zoster vaccination and healthy aging: Study connect the dots

Routine thyroid hormone treatment for organ donors ineffective and potentially harmful

Abnormally high levels of 'good cholesterol' linked to elevated risk of dementia in older adults

Study finds promising new approach to treating locally advanced pancreatic cancer

Exonate announces successful completion of Phase Ib/IIa trial in diabetic macular oedema

Multi-ingredient herbal supplement boosts cognitive speed and gut health in seniors

The potential of polyunsaturated fatty acids in alleviating depression and reducing suicide risk

Reducing cholesterol esters protects the brain against Alzheimer's-like damage

Study finds among outpatients with mild to moderate COVID-19, treatment with fluvoxamine does not reduce duration of symptoms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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