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Doctors advise against off-label use of new Alzheimer's medicine for cerebral amyloid angiopathy

A novel therapy recently approved by the U.S. Food and Drug Administration for patients with Alzheimer's disease amid considerable controversy should not be prescribed by physicians off-label for cerebral amyloid angiopathy (CAA), a similar cerebrovascular condition, according to Steven Greenberg, MD, PhD, director of the Hemorrhagic Stroke Research Program at Massachusetts General Hospital (MGH) and president of the International Cerebral Amyloid Angiopathy Association (ICAAA).

7 Jul 2021

Long-term exposure to air pollutants increases the risk of dysmenorrhea in women

Dysmenorrhea, that is, frequent severe and painful cramps during menstruation from abnormal contractions of the uterus, is the most common of all gynecological disorders. It affects between 16-91% of girls and women of reproductive age, of whom 2%-29% have symptoms severe enough to restrict their daily activity.

6 Jul 2021

Scientists unravel how cell death is initiated on a molecular level

The death of cells is well regulated. If it occurs too much, it can cause degenerative diseases. Too little, and cells can become tumors.

6 Jul 2021

Simple blood tests may help prevent inaccuracy in the diagnosis of severe malaria

Using simple blood tests could help researchers identify children who have been misidentified as having severe malaria, according to a study published today in eLife.

6 Jul 2021

Plant compounds inhibit Mpro of SARS-CoV-2 and HCoV-229E in vitro

A group of researchers recently discussed their findings that a group of plant flavonols and dihydroflavonols exhibit antiviral efficacy against both SARS-CoV-2 and HCoV-229E.

6 Jul 2021

Researchers unravel mechanisms that produce individualized metabolism in leukemia

A research collaboration based in Kumamoto University (Japan) has shown that lysine-specific demethylase 1 (LSD1), an enzyme involved in gene expression, produces individualized metabolism depending on the type of acute myeloid leukemia cells.

6 Jul 2021

Anti-rheumatic drug combinations could reduce the risk of heart attack and strokes

New research evaluating the drugs commonly used by rheumatoid arthritis patients suggests two combinations could reduce the risk of heart attack and strokes.

6 Jul 2021

Gene-edited cellular therapeutics can successfully treat cardiovascular and pulmonary diseases

Scientists at UC San Francisco have shown that gene-edited cellular therapeutics can be used to successfully treat cardiovascular and pulmonary diseases, potentially paving the way for developing less expensive cellular therapies to treat diseases for which there are currently few viable options.

6 Jul 2021

New method expands view into activity of single cells

Researchers have devised a way to multiply by more than ten-fold the accessible details of gene activity in individual cells. It's a big leap in the effort to understand cancer development, brain function, immunity and other biological processes driven by the complex interactions of multitudes of different cell types.

6 Jul 2021

New treatment targeting senescent cells boosts functional recovery from spinal cord injury

Senescent cells prevent tissue recovery following spinal cord injury, and a new drug targeting these cells could therefore improve functional recovery capacity.

6 Jul 2021

CRISPRa identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

New research led by Le Cong of Stanford University School of Medicine in California indicates that the KCNA6 potassium channel may help with viral entry and promote infection. In addition, KCNA6 is highly expressed in OLIG2+ neuronal cells, which has been shown to be suspectable to SARS-CoV-2 in the olfactory neuroepithelium. This area appears to contribute to loss of smell commonly observed during infection.

6 Jul 2021

Antibiotic clofoctol shows potential against SARS-CoV-2

In a recent study, a group of French researchers aimed to reduce the regulatory preclinical development steps that potential candidates are normally subjected to.

5 Jul 2021

Individual variation in viral dynamics could underlie inconsistencies in COVID-19 antiviral treatments

Due to variation in viral dynamics between people, improving the experimental design could help develop effective antiviral treatments for COVID-19.

5 Jul 2021

Researchers seek to find a cure for the deadliest solid tumor in children

Australian researchers and oncologists have been awarded $2.4 million to investigate the causes and treatments for neuroblastoma, the deadliest and most common solid tumor in children under the age of five.

5 Jul 2021

RNA-binding proteins represent a new class of drug targets for triple-negative breast cancer

In cancer research, it's a common goal to find something about cancer cells -- some sort of molecule -- that drives their ability to survive, and determine if that molecule could be inhibited with a drug, halting tumor growth. Even better: The molecule isn't present in healthy cells, so they remain untouched by the new therapy.

2 Jul 2021

Drugs News and Research

Doctors advise against off-label use of new Alzheimer's medicine for cerebral amyloid angiopathy

Long-term exposure to air pollutants increases the risk of dysmenorrhea in women

Scientists unravel how cell death is initiated on a molecular level

Simple blood tests may help prevent inaccuracy in the diagnosis of severe malaria

Plant compounds inhibit Mpro of SARS-CoV-2 and HCoV-229E in vitro

Researchers unravel mechanisms that produce individualized metabolism in leukemia

Anti-rheumatic drug combinations could reduce the risk of heart attack and strokes

Gene-edited cellular therapeutics can successfully treat cardiovascular and pulmonary diseases

New method expands view into activity of single cells

New treatment targeting senescent cells boosts functional recovery from spinal cord injury

CRISPRa identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

Antibiotic clofoctol shows potential against SARS-CoV-2

Individual variation in viral dynamics could underlie inconsistencies in COVID-19 antiviral treatments

Researchers seek to find a cure for the deadliest solid tumor in children

RNA-binding proteins represent a new class of drug targets for triple-negative breast cancer

Researchers repurpose existing drugs to reduce severity of sleep apnea by at least 30%

Study demonstrates successful postinfection treatment for SARS-CoV-2

Repurposing existing medications to reduce the severity of sleep apnea

B cell depleting agents can cause altered immune responses to COVID-19 vaccines, suggests study

New $1.7 million project to identify potential COVID-19 treatments

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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