Genetic News and Research

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Structure-based model of SARS-CoV-2 spike protein reveals opportunity to halt virus transmission

Scientists have simulated the transition of the SARS-CoV-2 spike protein structure from when it recognizes the host cell to when it gains entry, according to a study published today in eLife.

1 Sep 2021

A global genetic surveillance gap for SARS-CoV-2

Now a new study posted to the medRxiv* preprint server provides a perspective on the global disparities surrounding SARS-CoV-2 genomic surveillance, their causes and consequences, and possible solutions to maximize the impact of pathogen genome sequencing for efforts on public health.

1 Sep 2021

Breakthrough study could lead to much needed therapies for Huntington's disease

A new mechanism that stops the progression of Huntington's disease in cells has been identified by scientists at UCL and the University of Cambridge, as part of their research groups at the UK Dementia Research Institute.

31 Aug 2021

Targeting and inhibiting a protein could provide more effective treatment for brain cancer

McGill University researchers identify proteins that drive cancer stem cells. Targeting and supressing a particular protein called galectin1 could provide a more effective treatment for glioblastoma, in combination with radiation therapy.

31 Aug 2021

Researchers decipher genetic mechanisms governing the speed of protein synthesis

In all eukaryotic organisms, genetic material is stored in the cell nucleus in the form of DNA. In order to be used, this DNA is first transcribed into messenger RNA in the cell cytoplasm, then translated into protein with the help of ribosomes, small machines capable of decoding messenger RNA to synthesise the appropriate proteins.

31 Aug 2021

"FibroCOVID" - An emerging entity

In a recent study, a team of researchers aimed to investigate the prevalence and predictors of fibromyalgia in patients who recovered from COVID-19.

31 Aug 2021

Liquid biopsies could help identify, track bladder cancer and peripheral nerve tumors

Liquid biopsies detect tumor DNA in blood or urine samples. Two studies led by Washington University School of Medicine in St. Louis describe the potential of liquid biopsies to identify and track tumor growth in two very different cancers: bladder cancer and peripheral nerve tumors.

31 Aug 2021

Blood test could enable early detection of cancer in people with neurofibromatosis type 1

People with an inherited condition known as neurofibromatosis type 1, or NF1, often develop non-cancerous, or benign, tumors that grow along nerves. These tumors can sometimes turn into aggressive cancers, but there hasn't been a good way to determine whether this transformation to cancer has happened.

31 Aug 2021

Development of SARS-CoV-2 antibody escape variants in an immunocompromised individual

A new study published in mBio discusses the microevolution of SARS-CoV-2.

31 Aug 2021

Researchers identify biomarkers for rare, serious complication in children with COVID-19

The study focused on multisystem inflammatory syndrome in children (MIS-C), an inflammatory response involving multiple organs that can occur weeks after infection with SARS-CoV-2, the virus that causes COVID-19.

31 Aug 2021

Genomic autopsy reveals many genetic variants associated with cardiomyopathy

Postmortem genetic testing, or genomic autopsy, of young individuals who experienced sudden death revealed many had known genetic variants that are associated with cardiomyopathy, according to a Northwestern Medicine study published in JAMA Cardiology.

31 Aug 2021

Telemedicine appointments reduce risk of further illness in children with medical complexity

Telemedicine appointments combined with in-person visits significantly reduced the risk of further illness for children with medically complex cases, according to results of a new study by researchers with The University of Texas Health Science Center at Houston.

31 Aug 2021

Study uses novel technology to map the brain circuitry of spirituality

Scientists have long suspected that religiosity and spirituality could be mapped to specific brain circuits, but the location of those circuits remains unknown. Now, a new study using novel technology and the human connectome, a map of neural connections, has identified a brain circuit that seems to mediate that aspect of our personality. The work appears in Biological Psychiatry, published by Elsevier.

31 Aug 2021

Coronavirus buildup in the lungs is likely behind high mortality rates

A buildup of coronavirus in the lungs is likely behind the steep mortality rates seen in the pandemic, a new study finds.

31 Aug 2021

New, one-stop method developed to avoid de novo genetic disease in embryos

De novo variants (DNVs), genetic mutations that were not previously identifiable in the family history of one of two prospective parents, may cause disease in any children they have.

31 Aug 2021

Finding the genetic cause of childhood epilepsy helps improve treatment and care

Epilepsy is one of the most common chronic neurological diseases, affecting more than 50 million people worldwide. Although it is believed that a large proportion of childhood-onset epilepsies are caused by genetic changes, it remains unknown precisely how many of these patients suffer from a genetic disorder and how often the treatment can be targeted to their specific genetic alteration.

31 Aug 2021

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Oncotarget published "Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase" which reported that it is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase and characterize BTCs immunologically for evaluating the actionability of molecular and immune therapies.

31 Aug 2021

Research sheds light on potential biological mechanisms that impact adherence to medications

How strictly patients follow a prescribed drug treatment (drug adherence) is clearly important if the therapy is to have maximum effect. A number of things can affect adherence, including behavioral and socioeconomic factors, but to date there have been few investigations into the role played by genetics. Now, research to be presented at the annual conference of the European Society of Human Genetics today has thrown new light on the potential biological mechanisms that can affect adherence to treatment.

31 Aug 2021

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

Genetic tests can provide a better picture of cardiovascular disease risk than blood tests

Determining an individual's blood group based on genetic tests instead of merely traditional blood tests can provide a better picture of the risk of cardiovascular diseases.

30 Aug 2021

Genetic News and Research

Structure-based model of SARS-CoV-2 spike protein reveals opportunity to halt virus transmission

A global genetic surveillance gap for SARS-CoV-2

Breakthrough study could lead to much needed therapies for Huntington's disease

Targeting and inhibiting a protein could provide more effective treatment for brain cancer

Researchers decipher genetic mechanisms governing the speed of protein synthesis

"FibroCOVID" - An emerging entity

Liquid biopsies could help identify, track bladder cancer and peripheral nerve tumors

Blood test could enable early detection of cancer in people with neurofibromatosis type 1

Development of SARS-CoV-2 antibody escape variants in an immunocompromised individual

Researchers identify biomarkers for rare, serious complication in children with COVID-19

Genomic autopsy reveals many genetic variants associated with cardiomyopathy

Telemedicine appointments reduce risk of further illness in children with medical complexity

Study uses novel technology to map the brain circuitry of spirituality

Coronavirus buildup in the lungs is likely behind high mortality rates

New, one-stop method developed to avoid de novo genetic disease in embryos

Finding the genetic cause of childhood epilepsy helps improve treatment and care

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Research sheds light on potential biological mechanisms that impact adherence to medications

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Genetic tests can provide a better picture of cardiovascular disease risk than blood tests

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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