Preclinical News and Research

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Oestrogen research points to new class of analgesic drugs

Oestrogen plays an important role in determining how sensitive a person is to pain, and the oestrogen receptor known as ER-beta is particularly significant in this context.

13 Aug 2007

Light-activated molecules used to induce apoptosis in cancer cells

A key challenge facing doctors as they treat patients suffering from cancer or other diseases resulting from genetic mutations is that the drugs at their disposal often don't discriminate between healthy cells and dangerous ones -- think of the brute-force approach of chemotherapy, for instance.

12 Aug 2007

Handheld BrainScope device detects brain damage immediately after concussion

Researchers at NYU School of Medicine have developed a handheld device that can detect subtle brain damage immediately after concussion.

7 Aug 2007

Novavax begins human clinical testing of novel pandemic flu vaccine

Novavax has announced that it has begun vaccinating healthy volunteers in the first human clinical trial of its virus-like particle ("VLP") based pandemic influenza vaccine.

1 Aug 2007

Huntington's disease study shows animal models on target

An international team of researchers has published a benchmark study showing that gene expression in several animal models of Huntington's Disease (HD) closely resembles that of human HD patients.

1 Aug 2007

ZARS starts phase 3 trial of ThermoProfen

ZARS, Inc., has announced that it commenced the first of two Phase 3 clinical trials of ThermoProfen in patients with mild to moderate osteoarthritis (OA) of the knee on June 26, 2007.

26 Jul 2007

Arius begins toxicology program for lead anti-cancer antibody

ARIUS Research Inc has announced that the Company has initiated the first study in the formal pre-clinical toxicology program for its lead anti-CD44 drug candidate, which is under development for the treatment of breast, prostate and liver cancers.

23 Jul 2007

Affiris alzheimer's vaccine in clinical trial

The Alzheimer's vaccine known as Affitope AD01 from Affiris has now entered the clinical phase of its development. All relevant regulatory and statutory approvals have been secured and this innovative treatment is now being tested on humans for the first time.

19 Jul 2007

Suicide gene therapy for cancer

Cutting-edge research at South Dakota State University may yield a new therapy that targets only cancer cells, leaving healthy cells unharmed.

18 Jul 2007

Vegetable, fruit and fiber rich - low fat diet, does not appear to reduce breast cancer recurrence

Women with early stage breast cancer who adopted a diet very high in vegetables, fruit and fiber and low in fat did not have a lower risk of breast cancer recurrence compared to women who followed a diet of five or more servings a day of fruit and vegetables (the "5-A-Day" diet), according to a study in the July 18 issue of JAMA: The Journal of the American Medical Association.

18 Jul 2007

Researchers identify new combination therapy that promotes cancer cell death

Researchers at the University of Pennsylvania School of Medicine identified a combination therapy as a way to sensitize resistant human cancer cells to a treatment currently being tested in clinical trials They propose that the therapy may help to selectively eliminate cancer cells while leaving healthy cells intact, providing a cancer treatment with fewer side effects.

17 Jul 2007

Interleukin-6 - new target in the battle against Ras-induced cancers

In an upcoming Genes & Development paper, Dr. Christopher Counter and colleagues at the Duke University Medical Center have identified IL6 as a new target in the battle against Ras-induced cancers.

16 Jul 2007

Natural polymer Chitin shows great healing properties

Chitin is a polymer very common in nature as part of animals' and plants' physical structures.

16 Jul 2007

Scientists develop largest ever series of human breasts cancers grafted into mice

At the Institut Curie, Inserm researchers and physicians have established the largest ever panel of human breast cancer xenografts in animal models.

13 Jul 2007

Neural stem cells for Parkinson's disease

A University of South Florida neuroscientist reports that the cutting-edge research study of human stem cells in primates with Parkinson's disease is compelling on several fronts , particularly how the transplanted cells did their job of easing disease symptoms.

11 Jul 2007

Potential role of milk thistle as an anticancer agent

Milk thistle extract, an herbal remedy since the times of the ancient Greeks and Romans, is today one of the most popular herbal supplements, with U.S. retail sales of nearly nine million dollars.

11 Jul 2007

Catalyst Pharmaceutical Partners starts U.S. phase II trial of CPP-109 in patients with cocaine dependence

Catalyst Pharmaceutical Partners, Inc. a specialty pharmaceutical company that acquires or in-licenses, develops and commercializes prescription drugs for the treatment of drug addiction, today announced that it has initiated its randomized, double-blind, placebo-controlled U.S. Phase II clinical trial of CPP-109 in patients with cocaine dependence.

11 Jul 2007

Peregrine licenses worldwide rights to a novel anti-angiogenesis technology

Peregrine Pharmaceuticals, Inc. has announced that it has licensed worldwide exclusive rights to a novel anti-angiogenesis technology from The University of Texas M. D. Anderson Cancer Center.

10 Jul 2007

Gene therapy offers promising approach to tackle pancreatic cancer

A molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumors, inhibits metastasis, and prolongs survival with virtually no toxicity, researchers from The University of Texas M. D. Anderson Cancer Center report in the July 9 edition of Cancer Cell.

10 Jul 2007

Pieris progresses proprietary asthma program

Pieris AG, a bio-pharmaceutical company developing Anticalins, a novel class of targeted human protein therapeutics, today announced significant progress in validating novel, effective products for the potential treatment of asthma.

10 Jul 2007