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Researchers turn to machine learning to predict when immunotherapy will be effective

When it comes to defense, the body relies on attack thanks to the lymphatic and immune systems. The immune system is like the body's own personal police force as it hunts down and eliminates pathogenic villains.

30 Jun 2021

Scientists uncover new way to target a mutant protein that causes the deadliest of cancers

A new way to target a mutant protein which can cause the deadliest of cancers in humans has been uncovered by scientists at the University of Leeds.

30 Jun 2021

Breakthrough method for tracking mRNA molecules with fluorescence

Researchers at Chalmers University of Technology, Sweden, have succeeded in developing a method to label mRNA molecules, and thereby follow, in real time, their path through cells, using a microscope - without affecting their properties or subsequent activity.

30 Jun 2021

FDA approves alternative component of chemotherapy regimen to treat acute lymphoblastic leukemia

Today, the U.S. Food and Drug Administration approved Rylaze (asparaginase erwinia chrysanthemi (recombinant)-rywn) as a component of a chemotherapy regimen to treat acute lymphoblastic leukemia and lymphoblastic lymphoma in adult and pediatric patients who are allergic to the E. coli-derived asparaginase products used most commonly for treatment.

30 Jun 2021

UC screening program helps detect HIV outbreaks among persons who inject drugs

Newly published research shows that a screening program in the University of Cincinnati Medical Center Emergency Department helped detect an outbreak of HIV among persons who inject drugs in Hamilton County, Ohio, from 2014-18.

30 Jun 2021

Study uncovers common neural mechanism for cognitive impairment in autism and schizophrenia

Many neurodevelopmental disorders share similar symptoms, such as learning disabilities or attention deficits.

30 Jun 2021

SARS-CoV-2 inhibited by pyrimidine biosynthesis inhibitors in conjunction with nucleoside analogs

In an effort to hasten the research on identifying antiviral drugs for SARS-CoV-2 infection, researchers from the U.S. and Switzerland performed extensive drug screening for antiviral activity using live virus infection in human respiratory cells. As a result, they identified a set of possible drug candidates that could potentially be tested in clinical trials.

30 Jun 2021

New method to transport RNA-based drugs to subpopulation of immune cells

Tel Aviv University's groundbreaking technology may revolutionize the treatment of cancer and a wide range of diseases and medical conditions. In the framework of this study, the researchers were able to create a new method of transporting RNA-based drugs to a subpopulation of immune cells involved in the inflammation process, and target the disease-inflamed cell without causing damage to other cells.

30 Jun 2021

LSL60101 compound improves cognitive deficit in murine models with Alzheimer’s

The LSL60101 compound, a specific ligand of the I2-IR receptors in the brain, could shed light on the development of future strategies against Alzheimer's disease.

29 Jun 2021

UTA chemist develops cancer medication that uses light to destroy tumor cells

A chemist at The University of Texas at Arlington is developing a cancer medication that uses light to target and destroy tumor cells in a process known as photodynamic therapy (PDT).

29 Jun 2021

New components for oligonucleotide drugs show safety, efficacy in treating spinal muscular atrophy

Skoltech researchers and their colleagues from Russia and the UK investigated the safety and efficacy of new chemistry in antisense oligonucleotides used to treat spinal muscular atrophy (SMA), a debilitating genetic disease.

29 Jun 2021

Research shines new light on deadly medulloblastoma metastases

With advances in medical science driving progress against childhood brain tumors, today three out of four young patients survive at least five years beyond diagnosis. However, the outcomes look grim when malignant cells spread, or metastasize.

29 Jun 2021

Brain training based on 'neurofeedback' to manage ADHD

Attention Deficit Hyperactivity Disorder (ADHD) affects about 7% of children, with a two out of three chance of persisting into adulthood.

29 Jun 2021

How does dexamethasone therapy work in severe COVID-19?

The possible mechanisms that result in dexamethasone being an effective drug against severe SARS-CoV-2 infection are investigated in a new study. The paper’s authors advance the hypothesis that SARS-CoV-2 infection induces cell-specific insensitivity to glucocorticoids, possibly as an unintentional result of the viral replication cycle.

29 Jun 2021

Nanotechnology and the fight against COVID-19

In a review paper published in the open-access MDPI journal Viruses, a team of researchers explored the potential of nanotechnology to alleviate the current and future coronavirus burden. The team focused on its potential role in the detection, diagnosis, protection, and treatment of SARS-CoV-2 infection.

29 Jun 2021

Optibrium Publishes Major Peer-Reviewed Study on AI Applications to Global Pharma Data

Optibrium Limited today announced the publication of a peer-reviewed study in Applied AI Letters, “Deep Imputation on Large-Scale Drug Discovery Data”.

From Optibrium Ltd. 29 Jun 2021

Findings suggest that the cross-linking of fibrin proteins is key to reducing blood clot formation

Researchers have found that the y cross-chain structure of fibrin proteins is essential to stabilizing blood clots that can lead to harmful embolism formation.

29 Jun 2021

Scientists mimic the natural development of mammal using stem cells

The tiny mouse embryo has a heart that beats. Its muscles, blood vessels, gut and nervous system are beginning to develop. But this embryo is unusual: It was made in a lab, out of mouse embryonic stem cells, and represents the most sophisticated in vitro (in a dish) model of a mammal ever so created.

29 Jun 2021

Sleep-deprived individuals less likely to disclose information about past criminal activity

During the course of a criminal investigation, it is common for investigators to interview individuals who are exhausted and have had little sleep. While unavoidable in some cases, a new Iowa State University study found sleep disruption or deprivation may limit the amount of information provided during an interview.

29 Jun 2021

FDA's controversial decision to approve aducanumab for Alzheimer's treatment raises major ethical issues

The U.S. Food and Drug Administration's controversial decision to approve aducanumab for the treatment of Alzheimer's disease raises at least three major ethical issues that need to be addressed, states a new article in the Hastings Center Report:

29 Jun 2021

Drugs News and Research

Researchers turn to machine learning to predict when immunotherapy will be effective

Scientists uncover new way to target a mutant protein that causes the deadliest of cancers

Breakthrough method for tracking mRNA molecules with fluorescence

FDA approves alternative component of chemotherapy regimen to treat acute lymphoblastic leukemia

UC screening program helps detect HIV outbreaks among persons who inject drugs

Study uncovers common neural mechanism for cognitive impairment in autism and schizophrenia

SARS-CoV-2 inhibited by pyrimidine biosynthesis inhibitors in conjunction with nucleoside analogs

New method to transport RNA-based drugs to subpopulation of immune cells

LSL60101 compound improves cognitive deficit in murine models with Alzheimer’s

UTA chemist develops cancer medication that uses light to destroy tumor cells

New components for oligonucleotide drugs show safety, efficacy in treating spinal muscular atrophy

Research shines new light on deadly medulloblastoma metastases

Brain training based on 'neurofeedback' to manage ADHD

How does dexamethasone therapy work in severe COVID-19?

Nanotechnology and the fight against COVID-19

Optibrium Publishes Major Peer-Reviewed Study on AI Applications to Global Pharma Data

Findings suggest that the cross-linking of fibrin proteins is key to reducing blood clot formation

Scientists mimic the natural development of mammal using stem cells

Sleep-deprived individuals less likely to disclose information about past criminal activity

FDA's controversial decision to approve aducanumab for Alzheimer's treatment raises major ethical issues

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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