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New evidence on the links between immune activation and neuroinflammation and Parkinson's disease

In this special supplement to the Journal of Parkinson's Disease, "The Immune System in Parkinson's Disease," experts highlight the latest research breakthroughs on the links between immune activation and neuroinflammation and Parkinson's disease (PD) and discuss the challenges and novel therapeutic strategies targeting the immune system with the hope of reducing or reversing neurodegeneration.

1 Dec 2022

Study implicates a specific type of brain cell as key player underlying the impact of stressors

More than 70% of adults will experience at least one traumatic experience, such as a life-threatening illness or accident, violent assault or natural disaster, in their lifetimes and nearly a third will experience four or more, according to global data.

1 Dec 2022

New, nanotech-based strategy could enable safe, long-term treatment for autoimmune diseases

Scientists at Scripps Research have reported success in initial tests of a new, nanotech-based strategy against autoimmune diseases.

1 Dec 2022

Researchers develop 3D organoid model to advance understanding of gastroesophageal junction cancer

Researchers at Johns Hopkins Medicine say they have created a laboratory-grown three-dimensional "organoid" model that is derived from human tissue and designed to advance understanding about how early stages of cancer develop at the gastroesophageal junction (GEJ) — the point where the digestive system's food tube meets the stomach.

1 Dec 2022

UTHealth Houston professor wins $3.5 million to study the mechanisms of brain receptors involved in neurological disorders

A five-year, nearly $3.5 million grant to study the mechanisms of brain receptors involved in neurological disorders such as learning disabilities has been awarded to Vasanthi Jayaraman, PhD, of UTHealth Houston by the National Institutes of Health.

1 Dec 2022

HU begins human trial for promising treatment to reverse paralysis and language disorder after stroke

Hiroshima University started the human trial for a promising treatment that offers hope in potentially reversing paralysis and language disorder after moderate to severe stroke using therapeutically superior mesenchymal stem cells (MSCs) derived from the cranial bone.

1 Dec 2022

Scientists discover new potential mechanism for vision loss

Visual cells in the human retina may not simply die in some diseases, but are mechanically transported out of the retina beforehand.

1 Dec 2022

Novel prefusion S antigen designed by the mutation of the SARS-CoV-2 Spike protein’s trimeric structure

Researchers mutated the SARS-CoV-2 spike protein's trimeric structure to design a novel prefusion S antigen, S2D14.

1 Dec 2022

The requirement for Fc effector functions to protect against SARS-CoV-2 infection

Researchers determined which specific fragment crystallizable effector functions protect against SARS-CoV-2 infection, especially its emerging variants.

1 Dec 2022

Impact of COVID-19 on sperm quality

Researchers examined the effect of coronavirus disease 2019 (COVID-19) on sperm quality.

1 Dec 2022

Detection of filoviruses by the innate immune system

In a new study, researchers examined how the innate immune system detects filoviruses.

1 Dec 2022

INPP5D gene plays key role in enabling microglial cells to prevent plaque buildup

A change in the DNA code (mutation) of a gene that plays a key role in the brain's immune defenses may prevent related cells from clearing away protein-filled clumps, a new study in mice shows.

30 Nov 2022

Study provides novel therapeutic targets for enhancing the antitumor immunity of γδ-T cells in diabetes

A research team at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) discovered that high glucose impairs the antitumor activity of immune effector γδ-T cells, which contributes to the increased cancer risk in diabetes and that metabolic reprogramming by glucose control may improve the antitumor activity of γδ-T cells.

30 Nov 2022

Study provides a framework to guide the development of variant-resistant SARS-CoV-2 vaccines

Latest research findings show that vaccine-elicited neutralizing antibodies against SARS-CoV-2 are mostly directed against one of the two main domains of the viral entry machinery.

30 Nov 2022

Study suggests new strategies for making cartilage cells

As any weekend warrior understands, cartilage injuries to joints such as knees, shoulders, and hips can prove extremely painful and debilitating. In addition, conditions that cause cartilage degeneration, like arthritis and temporomandibular joint disorder (TMJ), affect 350 million people in the world and cost the US public health system more than $303 billion every year.

30 Nov 2022

SARS-CoV-2 can cause hyperglycemia in cats

In a recent study published in The Journal of Infectious Diseases, researchers explored the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hyperglycemia in cats.

30 Nov 2022

Removal of cilia from the brain's striatum impairs time perception and judgment, study finds

Researchers at the University of California, Irvine have discovered that removal of cilia from the brain's striatum region impaired time perception and judgment, revealing possible new therapeutic targets for mental and neurological conditions including schizophrenia, Parkinson's and Huntington's diseases, autism spectrum disorder, and Tourette syndrome.

30 Nov 2022

Detection of early-formed, antigen-specific clones in SARS-CoV-2-reactive B cells after longitudinal analysis

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, has globally infected more than 639 million individuals and claimed over 6.6 million lives. Despite the rapid commencement of COVID-19 vaccination programs in most countries across the world, the virus has remained in circulation.

30 Nov 2022

Human fetal cerebellar cell atlas reveals the origin of aggressive medulloblastomas

Studying mice has filled encyclopedias with breakthrough medical discoveries. But when it comes to brain cancers, the little rodents have long exhibited fundamental limitations.

30 Nov 2022

Stem cell crosstalk with the microenvironment creates a loop of tumor-promoting factors

What drives tumor growth? Is it a few rogue cells imposing their will upon healthy tissue, or diseased tissue bringing out the worst in otherwise peaceable cells? Or is it a back-and-forth, a dialogue between the two?

30 Nov 2022

B Cell News and Research

New evidence on the links between immune activation and neuroinflammation and Parkinson's disease

Study implicates a specific type of brain cell as key player underlying the impact of stressors

New, nanotech-based strategy could enable safe, long-term treatment for autoimmune diseases

Researchers develop 3D organoid model to advance understanding of gastroesophageal junction cancer

UTHealth Houston professor wins $3.5 million to study the mechanisms of brain receptors involved in neurological disorders

HU begins human trial for promising treatment to reverse paralysis and language disorder after stroke

Scientists discover new potential mechanism for vision loss

Novel prefusion S antigen designed by the mutation of the SARS-CoV-2 Spike protein’s trimeric structure

The requirement for Fc effector functions to protect against SARS-CoV-2 infection

Impact of COVID-19 on sperm quality

Detection of filoviruses by the innate immune system

INPP5D gene plays key role in enabling microglial cells to prevent plaque buildup

Study provides novel therapeutic targets for enhancing the antitumor immunity of γδ-T cells in diabetes

Study provides a framework to guide the development of variant-resistant SARS-CoV-2 vaccines

Study suggests new strategies for making cartilage cells

SARS-CoV-2 can cause hyperglycemia in cats

Removal of cilia from the brain's striatum impairs time perception and judgment, study finds

Detection of early-formed, antigen-specific clones in SARS-CoV-2-reactive B cells after longitudinal analysis

Human fetal cerebellar cell atlas reveals the origin of aggressive medulloblastomas

Stem cell crosstalk with the microenvironment creates a loop of tumor-promoting factors

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