Coronavirus News and Research

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Oxysterol derivatives show powerful antiviral activity against SARS-CoV-2 in vitro

A new study describes the antiviral activity of oxysterols, or oxidized cholesterol derivatives, against SARS-CoV-2. These occur in nature, and are not only involved in lipid signaling pathways that modulate a host of processes within the body, including the immune response and lipid homeostasis.

3 Feb 2021

Study finds higher pediatric SARS-CoV-2 burden than previously reported in the U.S.

In a new study, published on the pre-print server medRxiv*, researchers at Inova Children's Hospital and the George Mason University revealed that a much higher burden of SARS-CoV-2 infection was found in children than previously reported. This comes after the researchers assessed seropositivity among 1,038 children and adolescents.

3 Feb 2021

Novel strategy redirects generic antibodies to SARS-CoV-2 spike proteins

The SARS-CoV-2, the new coronavirus behind the current pandemic, infects humans by binding its surface-exposed spike proteins to ACE2 receptors exposed on the cell membranes.

3 Feb 2021

Airborne Infection Rate index predicts timing of second wave of pandemic

The "second wave" of the coronavirus pandemic has placed much blame on a lack of appropriate safety measures. However, due to the impacts of weather, research suggests two outbreaks per year during a pandemic are inevitable.

3 Feb 2021

Key variants help explain the differences between viruses that cause COVID-19 and SARS

An effort led by Lin Li, Ph.D., assistant professor of physics at The University of Texas at El Paso, in collaboration with students and faculty from Howard University, has identified key variants that help explain the differences between the viruses that cause COVID-19 and Severe Acute Respiratory Syndrome (SARS).

3 Feb 2021

One dose of VSV-vectored vaccine prevents SARS-CoV-2 replication in hamsters

A new preprint research paper posted to the bioRxiv server describes a viral vector vaccine candidate's efficacy to protect against SARS-CoV-2 replication in a hamster model.

3 Feb 2021

Study could help understand mechanisms of drug molecules to mitigate COVID-19 infection

As the scientific community continues researching the novel coronavirus, experts are developing new drugs and repurposing existing ones in hopes of identifying promising candidates for treating symptoms of COVID-19.

3 Feb 2021

J&J SARS-CoV-2 vaccine shows immunity in non-human primates 6 months after vaccination

A new preprint research paper released on the bioRxiv server discusses the findings from a model that assesses the association between the immunogenicity and protection conferred by a set of adenovirus- (Ad26)-vectored vaccines that express stabilized SARS-CoV-2 spike protein.

3 Feb 2021

Rapid SARS-CoV-2 antigen test improved with silver amplification

A new preprint posted to the medRxiv server describes the use of silver amplification technology to develop a sensitive, rapid antigen test for COVID-19.

2 Feb 2021

Prone positioning associated with lower mortality and intubation in COVID-19 patients

In the absence of specific antivirals to combat the pandemic, supportive care is paramount. In this context, a new preprint posted to the medRxiv server describes the observed efficacy of prone positioning to reduce mortality and the risk of intubation in COVID-19 patients with respiratory insufficiency.

2 Feb 2021

Single-dose vaccination effective for healthcare workers with prior SARS-CoV-2 infection

The findings reveal that healthcare workers previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop significantly higher antibody titers in response to a single dose of COVID-19 vaccine, as compared to healthcare workers without prior SARS-CoV-s infection. The study is currently available on the medRxiv* preprint server.

2 Feb 2021

Highly conserved neutralizing epitope identified on SARS-CoV-2 spike protein

A recent study conducted at the University of Texas at Austin, USA, has identified a highly conserved neutralizing antibody binding site on the spike S2 domain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study findings might help develop novel spike-targeting antibodies for widespread protection. The study is currently available on the bioRxiv preprint server.

2 Feb 2021

Lysosomal-immune axis associated with COVID-19 severity

New research suggests the modulation of lysosomal-immune pathways may present a novel drug-targeting strategy to attenuate SARS-CoV-2 infections.

2 Feb 2021

Immune profiling shows differences in COVID-19 and influenza pathologic pathways

A study conducted at Johns Hopkins University School of Medicine in Baltimore has revealed distinct differences in the immune pathways that are activated by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and those that are activated by influenza.

2 Feb 2021

Most of the telehealth appointments found to be audio-only visits

Telehealth use has surged during the pandemic at clinics that serve lower-income Americans, which allowed the clinics to maintain access to care at a time when many other health care organizations saw significant declines in utilization, according to a new RAND Corporation study.

2 Feb 2021

Researchers develop rapid COVID-19 diagnostic test affordable for low-income families

A test that detects antibodies to the novel coronavirus in 10 minutes and costs only a fifth of the market average has been developed by researchers at the University of São Paulo's São Carlos Chemistry Institute and Brazilian startup Biolinker, with São Paulo Research Foundation - FAPESP's support.

2 Feb 2021

Previous SARS-CoV-2 infection may negate need for two vaccine doses

Researchers in the United States have shown that two doses of vaccine may not be necessary to protect against coronavirus disease 2019 (COVID-19) among people who have already been infected with the causative agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

2 Feb 2021

Study shows link between periodontitis and COVID-19 complications

COVID-19 patients are at least three times more likely to experience complications if they also have gum disease, according to research published today in the Journal of Clinical Periodontology, the official publication of the European Federation of Periodontology.

2 Feb 2021

What is the structure and function of SARS-CoV-2’s D614G spike mutation?

A team of researchers use a computational approach to integrate available data D614G SARS-CoV-2 spike mutation, exploring its structure and molecular mechanisms.

2 Feb 2021

Zinc supplementation bolsters repurposed antivirals against SARS-CoV-2

A new preprint reports the efficacy of two repurposed drugs that could be useful against SARS-CoV-2 when supplemented with zinc.

2 Feb 2021

Coronavirus News and Research

Oxysterol derivatives show powerful antiviral activity against SARS-CoV-2 in vitro

Study finds higher pediatric SARS-CoV-2 burden than previously reported in the U.S.

Novel strategy redirects generic antibodies to SARS-CoV-2 spike proteins

Airborne Infection Rate index predicts timing of second wave of pandemic

Key variants help explain the differences between viruses that cause COVID-19 and SARS

One dose of VSV-vectored vaccine prevents SARS-CoV-2 replication in hamsters

Study could help understand mechanisms of drug molecules to mitigate COVID-19 infection

J&J SARS-CoV-2 vaccine shows immunity in non-human primates 6 months after vaccination

Rapid SARS-CoV-2 antigen test improved with silver amplification

Prone positioning associated with lower mortality and intubation in COVID-19 patients

Single-dose vaccination effective for healthcare workers with prior SARS-CoV-2 infection

Highly conserved neutralizing epitope identified on SARS-CoV-2 spike protein

Lysosomal-immune axis associated with COVID-19 severity

Immune profiling shows differences in COVID-19 and influenza pathologic pathways

Most of the telehealth appointments found to be audio-only visits

Researchers develop rapid COVID-19 diagnostic test affordable for low-income families

Previous SARS-CoV-2 infection may negate need for two vaccine doses

Study shows link between periodontitis and COVID-19 complications

What is the structure and function of SARS-CoV-2’s D614G spike mutation?

Zinc supplementation bolsters repurposed antivirals against SARS-CoV-2

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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