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Researchers identify new suppressor of cancer metastasis

Among patients with deadly cancers, more than 90 percent die because of metastatic spread of their disease. Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

14 Jul 2014

Tute Genomics agrees to provide NGS analytics for Lineagen's NextStepDx PLUS

Tute Genomics, the leader in genome annotation and interpretation, today announced an agreement with Lineagen, Inc., to provide next-generation sequencing (NGS) analytics for Lineagen's NextStepDx PLUS.

11 Jul 2014

New approach for developing personalized gene therapies to treat retinitis pigmentosa

Columbia University Medical Center researchers have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss.

11 Jul 2014

New knowledge may expand treatments for patients with lung cancer

Studying the most common type of lung cancer, researchers have uncovered mutations in a cell-signaling pathway that plays a role in forming tumors.

10 Jul 2014

NANOG gene linked to tumours derived from stratified epithelia

Scientists from the Spanish National Cancer Research Centre (CNIO) have discovered that NANOG, an essential gene for embryonic stem cells, also regulates cell division in stratified epithelia-those that form part of the epidermis of the skin or cover the oesophagus or the vagina-in adult organisms.

10 Jul 2014

TCGA finds novel mutations in key cancer-causing pathway in lung adenocarcinoma

Researchers from The Cancer Genome Atlas Research Network have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer.

10 Jul 2014

NCGR, Simbiot join forces to create new solutions for handling genomic data

On Tuesday, the National Center for Genome Resources and Simbiot announced a strategic partnership to create new solutions for handling 'big data' in the genomics space.

9 Jul 2014

Genetic variants linked with greater risk for radiation-driven side effects in cancer patients

Key genetic variants may affect how cancer patients respond to radiation treatments, according to a study published this week in Nature Genetics.

8 Jul 2014

Samples from Chobani yogurt contain most virulent form of fungus

Samples isolated from Chobani yogurt that was voluntarily recalled in September 2013 have been found to contain the most virulent form of a fungus called Mucor circinelloides, which is associated with infections in immune-compromised people.

8 Jul 2014

Researchers identify new genes that likely contribute to asthma

In a study published yesterday in the scientific journal Nature Immunology, a group at the La Jolla Institute (LJI) led by Pandurangan Vijayanand, Ph.D. identify new genes that likely contribute to asthma, a disease that currently affects over 200 million people world wide.

8 Jul 2014

High-resolution, high-throughput pre-implantation genetic screening microarray launched by OGT

Oxford Gene Technology (OGT), The Molecular Genetics Company, has announced the launch of a new high-resolution, high-throughput pre-implantation genetic screening (PGS) microarray aimed at improving embryo screening for in vitro fertilisation (IVF). The CytoSure™ Embryo Screen Array offers eight arrays of 60,000 spots for high-resolution genome-wide aneuploidy and copy number detection in pre-implantation embryos.

From Oxford Gene Technology 8 Jul 2014

Pseudogenes may play key role in the discovery of new biomarkers

Dysfunctional, unloved and seemingly of little use, these poor-cousin relatives of genes have lost their protein-coding abilities. They contain material not essential for an organism's survival and are the "last stop" for removal of genomic waste.

8 Jul 2014

Fungus responsible for outbreak of Greek yogurt can threaten health systems

The fungus responsible for an outbreak of contaminated Greek yogurt last year is not harmless after all but a strain with the ability to cause disease, according to research published in mBio-, the online open-access journal of the American Society for Microbiology.

8 Jul 2014

Reaction Biology awarded Phase I SBIR grant to create epigenetic database

Reaction Biology Corporation announced today that it has been awarded a Phase I SBIR grant from the National Center for Advancing Translational Sciences to create a database of epigenetic drug interactions.

8 Jul 2014

CWRU receives $12.6 million from NIA to identify rare genetic variants that contribute to Alzheimer's

Researchers from Case Western Reserve University School of Medicine are part of a five-university collaboration receiving a $12.6 million, four-year grant from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), to identify rare genetic variants that may either protect against, or contribute to Alzheimer's disease risk.

8 Jul 2014

Research on intestinal microbiota overturns vision of human gut ecosystem

An international research team within the MetaHIT consortium coordinated by INRA and involving teams from CEA, CNRS and Université d'Evry, has developed a new method to analyse the global genome, or the metagenome of the intestinal microbiota.

7 Jul 2014

CNIOA researchers update number of human genes to 19,000

How nutrients are metabolised and how neurons communicate in the brain are just some of the messages coded by the 3 billion letters that make up the human genome.

4 Jul 2014

Scientists find unexpected degree of complexity in transcriptional enhancers’ interactions

Contrary to what was thought, sequences of DNA called enhancers - which control a gene's output - find their targets long before they are activated during embryonic development, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found.

4 Jul 2014

Researchers reveal how schizophrenia-linked genetic variation alters skeletons of developing brain cells

Johns Hopkins researchers have begun to connect the dots between a schizophrenia-linked genetic variation and its effect on the developing brain. As they report July 3 in the journal Cell Stem Cell, their experiments show that the loss of a particular gene alters the skeletons of developing brain cells, which in turn disrupts the orderly layers those cells would normally form.

4 Jul 2014

genOway to provide EUCOMM conditional knockout mouse models to study human diseases

genOway, the biotechnology company dedicated to the development of genetically modified animal models, the Wellcome Trust Sanger Institute (UK) and Helmholtz Zentrum München (Germany), members of the EUCOMM Program (European Conditional Mouse Mutagenesis Program) and its successor program EUCOMMTOOLS (EUCOMM: Tools for functional annotation of the mouse genome) announce today the signing of a license enabling genOway to provide industry scientists with conditional knockout (KO) models developed by EUCOMM.

3 Jul 2014

Genome News and Research

Researchers identify new suppressor of cancer metastasis

Tute Genomics agrees to provide NGS analytics for Lineagen's NextStepDx PLUS

New approach for developing personalized gene therapies to treat retinitis pigmentosa

New knowledge may expand treatments for patients with lung cancer

NANOG gene linked to tumours derived from stratified epithelia

TCGA finds novel mutations in key cancer-causing pathway in lung adenocarcinoma

NCGR, Simbiot join forces to create new solutions for handling genomic data

Genetic variants linked with greater risk for radiation-driven side effects in cancer patients

Samples from Chobani yogurt contain most virulent form of fungus

Researchers identify new genes that likely contribute to asthma

High-resolution, high-throughput pre-implantation genetic screening microarray launched by OGT

Pseudogenes may play key role in the discovery of new biomarkers

Fungus responsible for outbreak of Greek yogurt can threaten health systems

Reaction Biology awarded Phase I SBIR grant to create epigenetic database

CWRU receives $12.6 million from NIA to identify rare genetic variants that contribute to Alzheimer's

Research on intestinal microbiota overturns vision of human gut ecosystem

CNIOA researchers update number of human genes to 19,000

Scientists find unexpected degree of complexity in transcriptional enhancers’ interactions

Researchers reveal how schizophrenia-linked genetic variation alters skeletons of developing brain cells

genOway to provide EUCOMM conditional knockout mouse models to study human diseases

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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