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SWOG researchers to present practice-changing research at virtual ASCO 2021

"SWOG always brings an impressive portfolio of work to the ASCO annual meeting," said SWOG Chair Charles D. Blanke, MD, "and this year I'm particularly excited about the research our investigators are presenting because it includes results that are likely to be practice-changing."

1 Jun 2021

Research offers new hope for people affected by the microdeletion of chromosome 22

One person in 2000 suffers from a microdeletion of chromosome 22 that can lead to the development of psychotic disorders, such as schizophrenia, in adolescence.

1 Jun 2021

NUS researchers develop a way to automate the production of pharmaceutical small molecules

The discovery and development of new small-molecule compounds for therapeutic use involves a huge investment of time, effort and resources.

1 Jun 2021

Glycosylated hemoglobin can provide a useful estimate of atherosclerosis and cardiovascular events

The routine use of the glycosylated hemoglobin test to track blood sugar levels in the general population can identify individuals with more advanced atherosclerotic disease.

1 Jun 2021

Study reveals inequities in access to primary care among Canadian prescription opioids users

Stigma and high care needs can present barriers to the provision of high-quality primary care for people with opioid use disorder (OUD) and those prescribed opioids for chronic pain.

1 Jun 2021

Miniature 3D bone marrow model could lead to personalized treatment for blood platelet disorders

A new miniature 3D model of human bone marrow has been described today in the open-access eLife journal.

1 Jun 2021

Scientists use an original approach to resolve the 3D structure of flaviviruses

In a recent study, Australian scientists used an original approach to resolve the 3D structure of flaviviruses with an unprecedented level of detail, identifying small molecules known as 'pocket factors' as new therapeutic targets.

1 Jun 2021

Antibody cocktail effectively inhibits SARS-CoV-2 in the rhesus macaque model

Researchers from the US tested the prophylactic potential of a combination of 2 mAbs administered 3 or 75 days before respiratory challenge in rhesus macaques. They used the rhesus macaque model to test the added benefit of combinatory parenteral administration of 2 high-affinity anti-SARS-CoV-2 mAbs - C144-LS and C135-LS. These mAbs were developed to neutralize the virus and tweaked to improve their pharmacokinetics.

1 Jun 2021

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

A team of researchers from the US and Belgium applied a structure-based approach with early monitoring of cathepsin L inhibition along with SARS-CoV-2 3CLpro inhibition. They identified a potent and selective SARS-CoV-2 3CLpro inhibitor, ALG-097111, which has proven activity against SARS-CoV-2 in SARS-CoV-2 hamster models in vivo. This study is published in the journal, Biochemical and Biophysical Research Communications.

1 Jun 2021

Little-known illnesses turning up in Covid long-haulers

The day Dr. Elizabeth Dawson was diagnosed with covid-19 in October, she awoke feeling as if she had a bad hangover. Four months later she tested negative for the virus, but her symptoms have only worsened.

1 Jun 2021

Cognitive reappraisal may reduce compulsive drug-seeking behavior in cocaine-addicted individuals

An emotion regulation strategy known as cognitive reappraisal helped reduce the typically heightened and habitual attention to drug-related cues and contexts in cocaine-addicted individuals, a study by Mount Sinai researchers has found.

31 May 2021

Diabetes remission diet can provide blood pressure control, reduce the need for anti-hypertensive drugs

New research has shown that if people achieve and maintain substantial weight loss to manage their type 2 diabetes, many can also effectively control their high blood pressure and stop or cut down on their anti-hypertensive medication.

31 May 2021

Review: Sulfur-containing natural products isolated from marine organisms

Announcing a new publication for Marine Life Science & Technology journal. In this review article the authors Yang Hai, Mei‑Yan Wei, Chang‑Yun Wang, Yu‑Cheng Gu and Chang‑Lun Shao from Ocean University of China, Qingdao, China and Syngenta Jealott's Hill International Research Centre, Berkshire, UK consider the chemistry and biology of sulfur‑containing natural products from marine microorganisms.

31 May 2021

SARS-CoV-2 NSP14 induces potent inflammation via NF-κB pathways, finds study

SARS-CoV-2 has a single-stranded RNA genome encoding both structural and non-structural proteins. Of these, the latter is known to play a variety of roles in viral replication and the assembly of new viral particles, as well as in suppressing cellular immune responses. A new study reports the activity of one such protein, the non-structural protein 14 (NSP14), which activates the inflammatory mediator NF-κB to trigger intense inflammation.

31 May 2021

UVA researchers shed new light on brain development

University of Virginia School of Medicine researchers have shed new light on how our brains develop, revealing that the very last step in cell division is crucial for the brain to reach its proper size and function.

31 May 2021

Intra-host SARS-CoV-2 composition varies over time, hinting at viral evolution during infection

Researchers at the Southern University of Science and Technology in China revealed rapid and dramatic changes in quasispecies diversity upon evaluating the SARS-CoV-2 populations present in the upper and lower respiratory tracts of patients with varying COVID-19 severity.

31 May 2021

Corilagin: could a plant compound used in Chinese herbal medicine help prevent COVID-19?

The study, published in the journal Phytomedicine, characterized an active compound, corilagin (a derivative from Phyllanthus urinaria), as potential SARS-CoV-2 entry inhibitors for its preventive application in daily antiviral hygiene products.

31 May 2021

Study could help identify risk of secondary leukaemia in certain children

Scientists from the Wellcome Sanger Institute and the University of Cambridge found that in children with neuroblastoma - a cancer of immature nerve cells - treatment with platinum chemotherapy caused changes to the genome that could then cause leukaemia in some children later on.

31 May 2021

New study may help improve stem cell transplantation, lead to better drugs

Your immune system is always busy fighting incoming threats. It consists of a system of cells, and when there is a shortage of cells, it affects the performance of the immune system.

29 May 2021

New drug effectively prevents severe COVID-19 in mice infected with SARS-CoV-2

The drug diABZI which activates the body's innate immune response -- was highly effective in preventing severe COVID-19 in mice that were infected with SARS-CoV-2, according to scientists in the Perelman School of Medicine at the University of Pennsylvania

29 May 2021

Drugs News and Research

SWOG researchers to present practice-changing research at virtual ASCO 2021

Research offers new hope for people affected by the microdeletion of chromosome 22

NUS researchers develop a way to automate the production of pharmaceutical small molecules

Glycosylated hemoglobin can provide a useful estimate of atherosclerosis and cardiovascular events

Study reveals inequities in access to primary care among Canadian prescription opioids users

Miniature 3D bone marrow model could lead to personalized treatment for blood platelet disorders

Scientists use an original approach to resolve the 3D structure of flaviviruses

Antibody cocktail effectively inhibits SARS-CoV-2 in the rhesus macaque model

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

Little-known illnesses turning up in Covid long-haulers

Cognitive reappraisal may reduce compulsive drug-seeking behavior in cocaine-addicted individuals

Diabetes remission diet can provide blood pressure control, reduce the need for anti-hypertensive drugs

Review: Sulfur-containing natural products isolated from marine organisms

SARS-CoV-2 NSP14 induces potent inflammation via NF-κB pathways, finds study

UVA researchers shed new light on brain development

Intra-host SARS-CoV-2 composition varies over time, hinting at viral evolution during infection

Corilagin: could a plant compound used in Chinese herbal medicine help prevent COVID-19?

Study could help identify risk of secondary leukaemia in certain children

New study may help improve stem cell transplantation, lead to better drugs

New drug effectively prevents severe COVID-19 in mice infected with SARS-CoV-2

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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