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Astellas, Ambit announce results from quizartinib Phase 2 study on acute myeloid leukemia

Astellas Pharma Inc. and Ambit Biosciences Corporation announced today that the results from a completed Phase 2 study with the investigational FLT3 inhibitor, quizartinib (AC220), as an oral monotherapy treatment regimen in patients with relapsed or refractory acute myeloid leukemia (AML) were presented at the 54th Annual Meeting of the American Society of Hematology (ASH).

11 Dec 2012

Cedars-Sinai first in Los Angeles County to achieve Comprehensive Stroke Center Certification

Cedars-Sinai is one of the first five medical centers in the nation and the first in Los Angeles County to achieve Comprehensive Stroke Center Certification from The Joint Commission and the American Heart Association/American Stroke Association.

11 Dec 2012

Traumatic brain injury incidence: an interview with Professor Valery Feigin

Traumatic brain injury can be defined as an injury to the brain due to mechanical forces. Mechanical forces usually include falls, car accidents, accidental forces from another person or animal. It also includes sports-related brain injuries.

11 Dec 2012

Naltrexone may help avoid weight gain among women smokers

A medication being tested to help smokers kick the habit also may help avoid the weight gain that is common after quitting but only in women, according to a study published in the December issue of Biological Psychiatry. This is the first medication shown to reduce weight gain for up to one year in women smokers who quit.

11 Dec 2012

Lack of TDP-43 protein can lead to frontotemporal dementia/ALS

Researchers at Mayo Clinic in Florida have uncovered a toxic cellular process by which a protein that maintains the health of neurons becomes deficient and can lead to dementia.

11 Dec 2012

Oxytocin administration to fathers increases parental engagement with their infants

A large body of research has focused on the ability of oxytocin to facilitate social bonding in both marital and parenting relationships in human females. A new laboratory study, led by Dr. Ruth Feldman from Bar-Ilan University in Israel and published in the current issue of Biological Psychiatry, has found that oxytocin administration to fathers increases their parental engagement, with parallel effects observed in their infants.

11 Dec 2012

Auditory systems differ between sexes in sparrows depending on the season

Auditory systems differ between sexes in sparrows depending on the season, a Georgia State University neuroscientist has found. The work adds to our knowledge of how the parts of the nervous system, including that of humans, are able to change.

10 Dec 2012

Janssen receives FDA approval for ZYTIGA to treat metastatic castration-resistant prostate cancer

Janssen announced today that the U.S. Food and Drug Administration (FDA) has approved a broader indication for the oral, once-daily medication ZYTIGA (abiraterone acetate).

10 Dec 2012

Wellcome Trust researchers discover how brain assesses confidence in its decisions

Wellcome Trust researchers have discovered how the brain assesses confidence in its decisions. The findings explain why some people have better insight into their choices than others.

10 Dec 2012

Angiocidin reduces acute myeloid leukemia cells in vivo by almost two-thirds in pre-clinical studies

Angiocidin, a novel tumor-inhibiting protein, has been shown to reduce acute myeloid leukemia (AML) cells in vivo by almost two-thirds in pre-clinical experiments.

10 Dec 2012

Results of Halaven Phase III study in metastatic breast cancer presented at 2012 CTRC-AACR SABCS

Results from the first large, global Phase III study of Halaven (eribulin mesylate) Injection in patients with early-stage metastatic breast cancer were presented today during the 2012 CTRC-AACR San Antonio Breast Cancer Symposium.

7 Dec 2012

Ultrasound applied to fingertips can stimulate sensory pathways leading to the brain

A century after the world's first ultrasonic detection device - invented in response to the sinking of the Titanic -Virginia Tech Carilion Research Institute scientists have provided the first neurophysiological evidence for something that researchers have long suspected: ultrasound applied to the periphery, such as the fingertips, can stimulate different sensory pathways leading to the brain.

7 Dec 2012

Scientists describe network map of genes involved in pain perception

Scientists in Australia and Austria have described a "network map" of genes involved in pain perception, with remarkable similarity from fruit flies to people. The work should help identify new analgesic drugs.

7 Dec 2012

Study reveals dual role for Norrin/Frizzled-4 protein pair

Working with mice, Johns Hopkins researchers have shed light on the activity of a protein pair found in cells that form the walls of blood vessels in the brain and retina, experiments that could lead to therapeutic control of the blood-brain barrier and of blood vessel growth in the eye.

7 Dec 2012

BDNF molecule appears to play a direct role in regulation of blood pressure

Researchers at Oregon Health & Science University's School of Dentistry have made an important connection between a molecule critical to nerve cells and high blood pressure. Production of the molecule Brain-Derived Neurotrophic Factor (BDNF) appears to increase dramatically in blood pressure-sensing nerve cells during hypertension.

7 Dec 2012

Kessler Foundation to study effects of intellectual enrichment on cognitive decline in people with MS

The National Multiple Sclerosis (MS) Society awarded Victoria Leavitt, Ph.D., a $44,000 grant to study the effects of intellectual enrichment on cognitive decline in individual with multiple sclerosis.

7 Dec 2012

Scientists identify key molecular pathway that leads to depression

Scientists have identified the key molecular pathway leading to depression, revealing potential new targets for drug discovery, according to research led by King's College London's Institute of Psychiatry. The study, published today in Neuropsychopharmacology, reveals for the first time that the 'Hedgehog pathway' regulates how stress hormones, usually elevated during depression, reduce the number of brain cells.

6 Dec 2012

Scientists develop MitoFish for in vivo studies of mitochondria transport in nerve cells

Scientists have demonstrated a new way to investigate mechanisms at work in Alzheimer's and other neurodegenerative diseases, which also could prove useful in the search for effective drugs. For new insights, they turned to the zebrafish, which is transparent in the early stages of its life. The researchers developed a transgenic variety, the "MitoFish," that enables them to see - within individual neurons of living animals - how brain diseases disturb the transport of mitochondria, the power plants of the cell.

6 Dec 2012

TSRI scientist to better define how brain organizes different types of memories among neurons

A scientist from the Florida campus of The Scripps Research Institute (TSRI) has been awarded approximately $2.5 million from the National Institute of Neurological Disorders and Stroke to better define how the brain organizes different types of memories among its neurons.

6 Dec 2012

New method can generate stable human mesenchymal stem cells for bone engineering

Human mesenchymal stem cells (hMSCs) can develop into bone cells and are useful for tissue engineering and regeneration. However, when grown in the laboratory they quickly lose their ability to continue dividing and they die.

5 Dec 2012

Neuroscience News and Research

Astellas, Ambit announce results from quizartinib Phase 2 study on acute myeloid leukemia

Cedars-Sinai first in Los Angeles County to achieve Comprehensive Stroke Center Certification

Traumatic brain injury incidence: an interview with Professor Valery Feigin

Naltrexone may help avoid weight gain among women smokers

Lack of TDP-43 protein can lead to frontotemporal dementia/ALS

Oxytocin administration to fathers increases parental engagement with their infants

Auditory systems differ between sexes in sparrows depending on the season

Janssen receives FDA approval for ZYTIGA to treat metastatic castration-resistant prostate cancer

Wellcome Trust researchers discover how brain assesses confidence in its decisions

Angiocidin reduces acute myeloid leukemia cells in vivo by almost two-thirds in pre-clinical studies

Results of Halaven Phase III study in metastatic breast cancer presented at 2012 CTRC-AACR SABCS

Ultrasound applied to fingertips can stimulate sensory pathways leading to the brain

Scientists describe network map of genes involved in pain perception

Study reveals dual role for Norrin/Frizzled-4 protein pair

BDNF molecule appears to play a direct role in regulation of blood pressure

Kessler Foundation to study effects of intellectual enrichment on cognitive decline in people with MS

Scientists identify key molecular pathway that leads to depression

Scientists develop MitoFish for in vivo studies of mitochondria transport in nerve cells

TSRI scientist to better define how brain organizes different types of memories among neurons

New method can generate stable human mesenchymal stem cells for bone engineering

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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