Bone News and Research

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Positive interim data from cabozantinib Phase 2 metastatic castration-resistant prostate cancer trial

Exelixis, Inc. today reported updated interim data from the cohort of patients with metastatic castration-resistant prostate cancer (CRPC) treated with cabozantinib (XL184) in an ongoing phase 2 adaptive randomized discontinuation trial.

18 Feb 2011

Two studies investigate frontiers of islet cell transplantation for treating diabetes

Two studies published in the current issue of Cell Transplantation investigate frontiers of islet cell transplantation for treating diabetes. Researchers in Milan, Italy re-examine the role of bone marrow stem cells in diabetic therapy and islet cell regeneration and Canadian researchers offer improved strategies for optimizing pancreatic islet culture in vitro.

18 Feb 2011

Loyola offers stem cell transplants to older patients with leukemia and lymphoma

As the first baby boomers turn 65, Loyola University Hospital has begun offering stem cell transplants to leukemia and lymphoma patients who previously were too old to qualify.

18 Feb 2011

Intrinsic initiates enrollment in Barricaid device clinical trial

Intrinsic Therapeutics, Inc., a developer of novel lumbar spine anulus closure devices, announced today that it has enrolled the first patient, December 17, 2010, in a Randomized Clinical Trial of its Barricaid device.

18 Feb 2011

Skeleton regulates fertility in males, but not females

Researchers at Columbia University Medical Center have discovered that the skeleton acts as a regulator of fertility in male mice through a hormone released by bone, known as osteocalcin.

17 Feb 2011

Cytochroma initiates CTAP101 repeat-dose safety, efficacy study in vitamin D insufficiency, SHPT and CKD

Cytochroma today announced the initiation of a repeat-dose safety and efficacy study of CTAP101 Capsules in patients with vitamin D insufficiency, secondary hyperparathyroidism (SHPT) and stage 3 chronic kidney disease (CKD).

17 Feb 2011

Zimmer introduces PathFinder NXT System for minimally invasive spinal procedures

Zimmer Holdings, Inc., a global leader in musculoskeletal care, today announced the launch of the PathFinder NXT System at the 2011 American Academy of Orthopaedic Surgeons annual meeting in San Diego, CA.

17 Feb 2011

ASTRO develops radiation therapy guideline for treating bone metastases

The American Society for Radiation Oncology Clinical Affairs and Quality Committee has developed a guideline for the use of radiation therapy in treating bone metastases. The guideline will be published in the International Journal of Radiation Oncology-Biology-Physics, an official journal of ASTRO.

17 Feb 2011

Positive preliminary data from ongoing PSMA ADC phase 1 study against prostate cancer

Progenics Pharmaceuticals, Inc. today reported positive preliminary data from an ongoing phase 1 study of PSMA ADC, an antibody-drug conjugate designed to selectively deliver chemotherapy to cells that express prostate-specific membrane antigen.

17 Feb 2011

Riverain Medical's chest X-ray computer-aided detection technology detects smaller lung nodules

Riverain Medical, an industry leader and innovator in computer-aided detection (CAD) and advanced visualization technologies, today announced a poster presentation, "A Superior Chest X-Ray Computer-Aided Detection (CXR CADe) Application: A Reader Study," has been published on the European Society of Radiology's website.

17 Feb 2011

Muscle, aptly enough, is born of cellular bullying, and not mutual consent

In fact, according to new research from Johns Hopkins, the fusion of muscle cells is a power struggle that involves a smaller mobile antagonist that points at, pokes and finally pushes into its larger, stationary partner using a newly identified finger-like projection.

17 Feb 2011

Medtronic: Kyphon Balloon Kyphoplasty provides better back pain relief in cancer patients

Medtronic Inc., today announced the results of the first randomized, controlled trial comparing Kyphon Balloon Kyphoplasty with non-surgical care in treating spinal fractures in cancer patients. The study found that Kyphon Balloon Kyphoplasty provided cancer patients better back-specific function, more rapid back pain relief and improved quality of life compared with non-surgical care one month after treatment.

17 Feb 2011

Study sheds light on novel functions of certain PCSK enzymes

Recent studies conducted at the Institut de recherches cliniques de Montr-al on a group of PCSK enzymes could have a positive impact on health, from cholesterol to osteoporosis.

17 Feb 2011

Sonablate HIFU device is now available in Brazil to treat prostate cancer

USHIFU LLC, a world leader in minimally invasive high intensity focused ultrasound technologies and manufacturer of the Sonablate 500 medical device, announces that HIFU with the Sonablate is available to prostate cancer patients for the first time in Brazil at Hospital Nossa Senhora das Gracas in Curitiba, capital city of the state of Parana in southern Brazil.

17 Feb 2011

Impaired brain insulin action may worsen type 2 diabetes

Researchers from Mount Sinai School of Medicine have discovered a novel function of brain insulin, indicating that impaired brain insulin action may be the cause of the unrestrained lipolysis that initiates and worsens type 2 diabetes in humans. The research is published this month in the journal Cell Metabolism.

17 Feb 2011

Bone remodeling inflammatory protein linked to metastatic lung cancer development in mice with breast cancer

When doctors discover high concentrations of regulatory T cells in the tumors of breast cancer patients, the prognosis is often grim, though why exactly has long been unclear.

16 Feb 2011

$Children with hip and thigh implants may face risk of bone fractures$

Children with hip and thigh implants may face risk of bone fractures

Children with hip and thigh implants designed to help heal a broken bone or correct other bone conditions are at risk for subsequent fractures of the very bones that the implants were intended to treat, according to new research from Johns Hopkins Children's Center.

16 Feb 2011

Integra launches Trel-XPress Demineralized Bone Matrix for orthopedic reconstruction surgery

Integra LifeSciences Holdings Corporation announced today the launch of Trel-XPress Demineralized Bone Matrix, expanding its portfolio of bone grafting substitutes for the orthopedic extremity reconstruction surgeon, which includes Integra OS Osteoconductive Scaffold, a synthetic bone void filler manufactured from beta tri-calcium phosphate and type I bovine collagen; Trel-X, a demineralized bone matrix; and Trel-XC, a demineralized bone matrix premixed with cancellous bone.

16 Feb 2011

Aeolus receives BARDA contract for AEOL 10150 drug development against ARS

Aeolus Pharmaceuticals, a biopharmaceutical company developing a new class of broad spectrum catalytic antioxidant compounds that reduce oxidative stress, inflammation, and subsequent tissue damage-signaling cascades resulting from radiation exposure, today announced that the Biomedical Advanced Research and Development Authority, part of the Department of Health and Human Services, has awarded Aeolus a contract for the advanced development of AEOL 10150 as a medical countermeasure against the pulmonary sub-syndrome of acute radiation syndrome.

16 Feb 2011

Orthofix 2010 net sales increase 3% to $564.4 million

Orthofix International N.V. today announced its results for the fourth quarter and year ended December 31, 2010.

16 Feb 2011

Bone News and Research

Positive interim data from cabozantinib Phase 2 metastatic castration-resistant prostate cancer trial

Two studies investigate frontiers of islet cell transplantation for treating diabetes

Loyola offers stem cell transplants to older patients with leukemia and lymphoma

Intrinsic initiates enrollment in Barricaid device clinical trial

Skeleton regulates fertility in males, but not females

Cytochroma initiates CTAP101 repeat-dose safety, efficacy study in vitamin D insufficiency, SHPT and CKD

Zimmer introduces PathFinder NXT System for minimally invasive spinal procedures

ASTRO develops radiation therapy guideline for treating bone metastases

Positive preliminary data from ongoing PSMA ADC phase 1 study against prostate cancer

Riverain Medical's chest X-ray computer-aided detection technology detects smaller lung nodules

Muscle, aptly enough, is born of cellular bullying, and not mutual consent

Medtronic: Kyphon Balloon Kyphoplasty provides better back pain relief in cancer patients

Study sheds light on novel functions of certain PCSK enzymes

Sonablate HIFU device is now available in Brazil to treat prostate cancer

Impaired brain insulin action may worsen type 2 diabetes

Bone remodeling inflammatory protein linked to metastatic lung cancer development in mice with breast cancer

Children with hip and thigh implants may face risk of bone fractures

Integra launches Trel-XPress Demineralized Bone Matrix for orthopedic reconstruction surgery

Aeolus receives BARDA contract for AEOL 10150 drug development against ARS

Orthofix 2010 net sales increase 3% to $564.4 million

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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