Apoptosis News and Research

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Apoptosis is programmed cell death, the body's normal method of disposing of damaged, unwanted, or unneeded cells.

Scientists discover how dying cells prevent dangerous immune reactions

Dying cells in the body can keep the immune system in check, thus preventing unwanted immune responses against the body's own tissues.

8 Jan 2020

Daily aspirin use may help prevent colorectal cancer

A new study has shown that regular use of aspirin may protect against heart disease, reduce colorectal tumor growth and prevent relapse.

7 Jan 2020

Discovery of cellular 'hands' could have implications in the fields of cell, developmental biology

The protein, called syndecan-4, combines with fellow cell membrane proteins, called integrins, to form protruding 'hands' that sense the environment outside the cell.

6 Jan 2020

Aspirin’s benefits may extend beyond heart health to colorectal cancer treatment

The benefits of a daily aspirin may extend beyond heart health to colorectal cancer treatment, say City of Hope researchers who have found aspirin appears to reduce tumor growth and inhibit recurrence of the disease.

6 Jan 2020

Certain bacteria can override programmed cell death

Certain bacteria can override a defense mechanism of the immune system, so called programmed cell death, through inhibition of death effector molecules by their outer membranes components.

26 Dec 2019

Immunologists discover new RIPK1 mechanism that leads to cell death

Scientists at St. Jude Children's Research Hospital have discovered a new way that the molecule RIPK1 leads to cell death in infected, damaged or unwanted cells showing that more than one mechanism can trigger the process.

23 Dec 2019

p53 may play a more important role in kidney cancer than previously thought

The p53 gene, which researchers had thought was less relevant in kidney cancer, may play an important role after all – a discovery that could lead to new treatments.

20 Dec 2019

Catastrophic macropinocytosis may aid in cancer treatment

In laboratory experiments, a metabolic inhibitor was able to kill a variety of human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route -- catastrophic macropinocytosis.

18 Dec 2019

Novel and targeted cellular product causes cell death in non-Hodgkin lymphoma models

Investigators at Rutgers Cancer Institute of New Jersey have found that a treatment based on a novel cellular product programmed to deliver an overabundance of chimeric antigen receptor causes cell death in non-Hodgkin lymphoma models that are sensitive or resistant to standard therapies.

16 Dec 2019

New tool gives more reliable and precise results in cancer research

Every cell contains a vast number of proteins, each of which has a specific function, for example as a receptor for another molecule or an enzyme that catalyzes chemical reactions.

16 Dec 2019

Researchers examine p53-deficient colon cancer cells to identify how p53 impacts metabolic adaptation

Colon cancer cells deficient in p53, one of the most important control proteins in cell growth, activate a particular metabolic pathway to adapt to the lack of oxygen and nutrients inside the tumor. Statins, which are often prescribed to lower cholesterol, block this metabolic pathway and cause the cancer cells to die, as scientists from the German Cancer Research Center have now discovered.

12 Dec 2019

Researchers investigate NOTCH1 mutations in keratinocyte lines derived from OSCC biopsies

The cover for issue 63 of Oncotarget features Figure 6, "Inverse relationship between ETV7 and SERPINE1 in OSCC," by Salameti, et al.

4 Dec 2019

Scientist earns prestigious award for research into cell suicide

Apoptosis is a form of “cell suicide”, where a cell self-terminates, ideally as planned or programmed, enabling multi-cellular organisms to continue to live, develop and thrive.

4 Dec 2019

Failure in proteasome transportation system may cause neurodegenerative diseases

All neurodegenerative diseases have a common thread: the appearance of protein clumps in the brain such as amyloid-beta plaques in Alzheimer's disease and alpha synuclein aggregates in Parkinson's.

3 Dec 2019

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

The growing trend of implementing immunotherapy into oncology has resulted in various new therapeutic cancer treatments utilizing antibodies.

From Sartorius 3 Dec 2019

Research findings provide novel therapeutic space to induce scarless regenerative healing

Abnormal scarring is a serious threat resulting in non-healing chronic wounds or fibrosis. Scars form when fibroblasts, a type of cell of connective tissue, reach wounded skin and deposit plugs of extracellular matrix.

27 Nov 2019

LACV-infected cerebral organoids reveal how to protect neurons from virus-induced death

Scientists have determined that La Crosse virus, which can cause inflammation of the brain, or encephalitis, in children, affects brain cells differently depending on their developmental stage.

26 Nov 2019

Mcl-1 inhibition blocks cell survival in ER+ breast cancers

While estrogen receptor - + breast cancers express high levels of three anti-apoptotic Bcl-2 family members, pharmacological inhibition of Bcl-2 and/or Bcl-xL fails to induce cell death in ER + breast cancer cell lines, due to rapid and robust Mcl-1 upregulation.

26 Nov 2019

Enzyme caspase-8 controls apoptosis, necroptosis and pyroptosis

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows.

26 Nov 2019

Apoptosis protein API-5 more markedly expressed in chemoresistant triple-negative breast cancer

78 TNBC biopsies from patients with different responses to chemotherapy were analysed for API-5 expression before any treatment.

25 Nov 2019

Apoptosis News and Research

Scientists discover how dying cells prevent dangerous immune reactions

Daily aspirin use may help prevent colorectal cancer

Discovery of cellular 'hands' could have implications in the fields of cell, developmental biology

Aspirin’s benefits may extend beyond heart health to colorectal cancer treatment

Certain bacteria can override programmed cell death

Immunologists discover new RIPK1 mechanism that leads to cell death

p53 may play a more important role in kidney cancer than previously thought

Catastrophic macropinocytosis may aid in cancer treatment

Novel and targeted cellular product causes cell death in non-Hodgkin lymphoma models

New tool gives more reliable and precise results in cancer research

Researchers examine p53-deficient colon cancer cells to identify how p53 impacts metabolic adaptation

Researchers investigate NOTCH1 mutations in keratinocyte lines derived from OSCC biopsies

Scientist earns prestigious award for research into cell suicide

Failure in proteasome transportation system may cause neurodegenerative diseases

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

Research findings provide novel therapeutic space to induce scarless regenerative healing

LACV-infected cerebral organoids reveal how to protect neurons from virus-induced death

Mcl-1 inhibition blocks cell survival in ER+ breast cancers

Enzyme caspase-8 controls apoptosis, necroptosis and pyroptosis

Apoptosis protein API-5 more markedly expressed in chemoresistant triple-negative breast cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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