Central Nervous System News and Research

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Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

A new study published in the journal Reports focused on the hijacking of the pancreatic, endothelial, and gut GABA by SARS-CoV-2 and its associated pathology along with interventions.

10 Jun 2022

Study shines new light on the role of key Parkinson’s disease protein

One of the hallmarks of Parkinson's disease (PD) is the accumulation in the brain of a protein known as alpha-synuclein. For more than two decades, alpha-synuclein has been a focal point of attention for researchers, clinicians and drug makers interested in PD.

9 Jun 2022

Shingles is not associated with increased risk of dementia, finds study

Shingles, a viral infection caused by the reactivation of the chickenpox virus, results in a painful blistering rash along one side of the body or face from nerve inflammation. There has been scientific speculation that such inflammation may increase a person's risk of dementia.

9 Jun 2022

Insilico Medicine plans to launch a fully automated AI-driven robotics lab for drug discovery

Insilico Medicine's end-to-end AI-driven drug discovery platform, Pharma.AI, draws its strength from the quality and quantity of its data. As Insilico scientific advisory board member and Nobel Prize laureate in chemistry Dr. Michael Levitt has said, Insilico's platform capitalizes on the ability of artificial intelligence to take vast amounts of data from many different components and find patterns and make predictions that can point the way to new life-saving medications.

9 Jun 2022

Review of cannabis use on reproductive health, pregnancy, and fetal outcomes

A recent study reviewed cannabis use on reproductive health, pregnancy, and fetal outcomes.

8 Jun 2022

Age exacerbates COVID neuroimmunological symptoms

In a recent study posted to the bioRxiv* pre-print server, researchers at the University of Illinois at Chicago investigated whether aging exacerbated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-induced neuropsychiatric disorders.

6 Jun 2022

Researchers repurpose a cancer drug for the treatment of neuroinflammatory diseases

The repurposing of FDA-approved drugs for alternative diseases is a faster way of bringing new treatments into the clinic.

3 Jun 2022

Study: Nearly 43% of patients with KRAS-mutated lung cancer respond to experimental drug adagrasib

Nearly 43% of patients with non-small cell lung cancer (NSCLC) whose lung cancers harbored a specific KRAS mutation responded to the experimental drug adagrasib, and the targeted agent also showed activity against lesions in the brain that metastasized from the lung tumors, according to results of a study led by Dana-Farber Cancer Institute investigators.

3 Jun 2022

Study shows the two-way association between IBD and depression in siblings

Inflammatory bowel disease (IBD) is a chronic condition involving inflammation of the digestive tract, affecting some 1.6 million Americans. Depression affects more than 16 million Americans.

2 Jun 2022

Cellular changes in astrocytes play a crucial role in regulating outcomes for CNS disorders

Investigators at Cedars-Sinai have comprehensively mapped molecular activity in the brain and spinal cord that is responsible for regulating the body's response to central nervous system (CNS) disorders such as Alzheimer's, Huntington's disease and spinal cord injuries.

2 Jun 2022

Scientists discover a new role for protein complex at the center of Bardet-Biedl syndrome

Scientists have identified a new role for a protein complex at the center of a human genetic disorder called Bardet-Biedl syndrome, or BBS, for which there is currently no cure.

31 May 2022

EEG data reveals when and where odors are processed in the brain

A specially created odor delivery device, along with machine learning-based analysis of scalp-recorded electroencephalogram, has enabled researchers at the University of Tokyo to see when and where odors are processed in the brain.

29 May 2022

New evidence confirms that enterovirus D68 causes acute flaccid myelitis

A case report published in the New England Journal of Medicine provides evidence that enterovirus D68 directly infects spinal cord neurons and that a corresponding robust immune response is present – a direct causation to the polio-like paralyzing illness, acute flaccid myelitis (AFM).

26 May 2022

We need to prepare for Monkeypox - now confirmed in 21 countries

Efforts should be made to curb the spread of this virus in order to prevent another pandemic.

25 May 2022

Study measures viral antigen and inflammatory biomarkers in CSF of COVID-19 patients in relation to neurologic symptoms and disease severity

Researchers investigated the impact of coronavirus disease 2019 (COVID-19) on biomarkers in the cerebrospinal fluid (CSF).

25 May 2022

Insilico Medicine nominates novel preclinical candidate targeting 3CL protease for COVID-19 treatment

Insilico Medicine, a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, today announced its nomination of a novel preclinical candidate (PCC) targeting 3C-like (3CL) protease for the treatment of COVID-19.

24 May 2022

NIH awards first part of $30 million grant to USC team for stroke project

When administered soon after the onset of acute ischemic stroke, current approved treatments for the condition can dramatically improve patient outcomes.

24 May 2022

Gabapentin treatment may enhance recovery of movement after a stroke

The drug gabapentin, currently prescribed to control seizures and reduce nerve pain, may enhance recovery of movement after a stroke by helping neurons on the undamaged side of the brain take up the signaling work of lost cells, new research in mice suggests.

23 May 2022

Researchers analyze the development and genetic profile of brain's immune cells

Thanks to over a century of modern neuroscience, we have made significant strides in our understanding of the brain. Nonetheless, we have only just begun to scratch the surface of how this amazingly complex organ works.

20 May 2022

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

James Bibb, Ph.D., and colleagues have described a novel preclinical drug that could have the potential to combat depression, brain injury and diseases that impair cognition. The drug, which notably is brain-permeable, acts to inhibit the kinase enzyme Cdk5.

20 May 2022

Central Nervous System News and Research

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

Study shines new light on the role of key Parkinson’s disease protein

Shingles is not associated with increased risk of dementia, finds study

Insilico Medicine plans to launch a fully automated AI-driven robotics lab for drug discovery

Review of cannabis use on reproductive health, pregnancy, and fetal outcomes

Age exacerbates COVID neuroimmunological symptoms

Researchers repurpose a cancer drug for the treatment of neuroinflammatory diseases

Study: Nearly 43% of patients with KRAS-mutated lung cancer respond to experimental drug adagrasib

Study shows the two-way association between IBD and depression in siblings

Cellular changes in astrocytes play a crucial role in regulating outcomes for CNS disorders

Scientists discover a new role for protein complex at the center of Bardet-Biedl syndrome

EEG data reveals when and where odors are processed in the brain

New evidence confirms that enterovirus D68 causes acute flaccid myelitis

We need to prepare for Monkeypox - now confirmed in 21 countries

Study measures viral antigen and inflammatory biomarkers in CSF of COVID-19 patients in relation to neurologic symptoms and disease severity

Insilico Medicine nominates novel preclinical candidate targeting 3CL protease for COVID-19 treatment

NIH awards first part of $30 million grant to USC team for stroke project

Gabapentin treatment may enhance recovery of movement after a stroke

Researchers analyze the development and genetic profile of brain's immune cells

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

Event guide: The 7th CNS Drug Delivery Summit eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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