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What causes behavioral side effects in popular weight loss drugs?

The study of GLP1R variants shows associations with cardiometabolic traits and behavioral changes, highlighting indirect effects of GLP1RA on mental health.

23 Jan 2025

Dapagliflozin and calorie restriction show higher remission rates in type 2 diabetes

Adults with overweight or obesity and type 2 diabetes who are given the sodium glucose cotransporter 2 (SGLT-2) inhibitor drug dapagliflozin alongside moderate calorie restriction achieve much higher rates of remission compared with calorie restriction alone, finds a trial published by The BMJ today.

23 Jan 2025

Strong heart, strong bones: How cardiovascular health influences bone density

Higher cardiovascular health (Life’s Essential 8 scores) is linked to greater bone mineral density in adults aged 20–59, with stronger associations in younger individuals, women, and those with normal BMI, suggesting heart-healthy habits may protect bone strength.

22 Jan 2025

GLP1RA medications linked to behavioral side effects in type 2 diabetes and obesity

Glucagon-like peptide 1 receptor agonists (GLP1RA)-medications for type 2 diabetes and obesity that have recently been making headlines due to a rise in popularity as weight loss agents-have been linked with behavioral side effects.

22 Jan 2025

Fizzy water may aid weight loss but can't replace healthy lifestyle

Fizzy water might aid weight loss by boosting blood glucose uptake and metabolism-the rate at which the body uses and converts energy-but the effects are so small, drinking it can't be relied on alone to shed the pounds, concludes a brief analysis published in the open access journal BMJ Nutrition Prevention & Health.

21 Jan 2025

Antibiotics, antivirals, vaccines and anti-inflammatory drugs associated with reduced dementia risk

Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million individuals.

21 Jan 2025

How lifestyle-based interventions help manage PCOS

Studies indicate that lifestyle modifications can alleviate PCOS symptoms, improving insulin resistance and hormonal balance through diet and physical activity.

21 Jan 2025

TyG index linked to obesity measures can predict hypertension risk in US adults

A study found that the triglyceride-glucose (TyG) index, combined with obesity measures, significantly correlates with hypertension risk in American adults, offering potential for improved cardiovascular risk assessment.

20 Jan 2025

Researchers create an atlas of health associations for GLP-1 receptor agonists

Insights from a study on GLP-1 receptor agonists reveal benefits for cardiometabolic health, with notable risks for gastrointestinal and musculoskeletal issues.

20 Jan 2025

Intermuscular fat increases risk of heart disease independent of BMI

People with pockets of fat hidden inside their muscles are at a higher risk of dying or being hospitalized from a heart attack or heart failure, regardless of their body mass index, according to research published in the European Heart Journal today (Monday).

20 Jan 2025

Manuka vs. Ohia Lehua honey: Study reveals key antioxidant differences and health benefits

Study compares the antioxidant properties of Manuka honey (MH) and Ohia Lehua honey (OLH), revealing that MH contains ten times more phenolic content, while OLH demonstrates superior in vivo antioxidant activity by reducing oxidative stress and enhancing antioxidant capacity.

19 Jan 2025

New rabbit model provides insights into CF-related pancreatic endocrine pathology

Cystic fibrosis (CF) is a life-threatening genetic disease affecting multiple organ systems, with pancreatic dysfunction representing a critical and often overlooked complication.

17 Jan 2025

Immune cells orchestrate glucagon production during fasting

When we think about the immune system, we usually associate it with fighting infections. However, a study published in Science by the Champalimaud Foundation reveals a surprising new role.

17 Jan 2025

CGM data offers superior insights into diabetes complications

Data from continuous glucose monitors can predict nerve, eye and kidney damage caused by type 1 diabetes, University of Virginia Center for Diabetes Technology researchers have found. That suggests doctors may be able to use data from the devices to help save patients from blindness, diabetic neuropathy and other life-changing diabetes complications.

16 Jan 2025

Study identifies molecular mechanisms behind gestational diabetes progression

Among those who have had gestational diabetes, about 35% will develop type 2 diabetes within a decade.

15 Jan 2025

Semaglutide improves glycemic control with automated insulin delivery

Semaglutide combined with automated insulin delivery enhances glucose control in type 1 diabetes, lowering insulin requirements and aiding weight management.

15 Jan 2025

Machine learning identifies women at risk of severe cognitive decline during menopause

Artificial intelligence (AI) is positioned to make a major impact on almost every industry, including healthcare. A new study suggests that machine learning models can more quickly and affordably identify women with severe subjective cognitive decline during the menopause transition, effectively opening the door to better management of cognitive health. Results of the study are published online today in Menopause, the journal of The Menopause Society.

15 Jan 2025

Proteomic mapping identifies biomarkers driving healthy aging and preventing chronic diseases

Scientists mapped the serum proteome longitudinally to uncover biomarkers linked to healthy aging and cardiometabolic diseases, revealing potential therapeutic targets.

14 Jan 2025

High-fat diet linked to impulsive behaviors and brain changes

Researchers examines how a high-fat diet modifies inhibitory control.

14 Jan 2025

Retina vascular fingerprint offers non-invasive way to predict stroke risk

A vascular 'fingerprint' on the light sensitive tissue layer at the back of the eye-the retina-can predict a person's risk of stroke as accurately as traditional risk factors alone, but without the need for multiple invasive lab tests, finds research published online in the journal Heart.

13 Jan 2025