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Clearing old, dysfunctional cells in fat alleviates diabetes

Eliminating old, dysfunctional cells in human fat also alleviates signs of diabetes, researchers from UConn Health report. The discovery could lead to new treatments for Type 2 diabetes and other metabolic diseases.

22 Nov 2021

Nanocomputing agent controls the function of protein involved in cell movement, cancer metastasis

The creation of nanoscale computers for use in precision health care has long been a dream of many scientists and health care providers.

16 Nov 2021

Study identifies a host factor that reflects different levels of inflammation within mild COVID-19 cases

A new study investigates serum from COVID-19 convalescents and uninfected individuals to determine the molecular mechanisms of host responses.

15 Nov 2021

Could drugs derived from microalgae be effective against COVID-19?

Researchers discuss the ability of some microalgae metabolites to prevent cytokine storm syndrome during COVID-19.

15 Nov 2021

Study provides a new target for therapeutic intervention in Parkinson's disease

In an unexpected discovery, Georgetown University Medical Center researchers have identified what appears to be a significant vascular defect in patients with moderately severe Parkinson's disease.

14 Nov 2021

New evidence reveals a cancer-promoting role for MAPK6 enzyme

A team led by scientists at Baylor College of Medicine uncovered new evidence supporting a cancer-promoting role for enzyme MAPK6.

12 Nov 2021

New method of stem cell transplantation may eliminate the need for radiation or chemotherapy

Studying mice, researchers at Washington University School of Medicine in St. Louis have developed a method of stem cell transplantation that does not require radiation or chemotherapy.

10 Nov 2021

HSS study provides insight into real-world medication use for treatment of psoriatic arthritis

Despite clear directives outlined in the updated guidelines published by the American College of Rheumatology/National Psoriasis Foundation (ACR/NPF) in 2018, there is limited data regarding medication use in real-world clinical practice and patient medication preferences for the treatment of psoriatic arthritis (PsA).

9 Nov 2021

Study looks at how lupus genetics intersects with COVID-19

The study “Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19” was recently published on the preprint medRxiv* server.

8 Nov 2021

Ibrutinib plus standard chemotherapy effective in younger patients with diffuse large B-cell lymphoma

Younger patients with specific genetic subtypes of non-GCB DLBCL, called MCD and N1, had an exceptional response to the treatment combination.

5 Nov 2021

Adaptive immunity in patients infected with SARS-CoV-2 Δ382 Variant

A comprehensive characterization of the immune responses between SARS-CoV-2 infected individuals with wildtype (WT) and Δ382 SARS-CoV-2.

3 Nov 2021

Cycling JAK inhibitors can be effective for treating people with difficult-to-treat rheumatoid arthritis

New research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows that people with difficult-to-treat rheumatoid arthritis who do not have success with one Janus kinase inhibitor (JAK inhibitor) can achieve success either cycling to other JAKi medications or switching to a biologic drug.

2 Nov 2021

RA patients taking glucocorticoids or B-cell therapies may have worse COVID-19 vaccine response

New research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows that people with chronic inflammatory diseases, such as rheumatoid arthritis (RA), who take immunosuppressive therapy appear to have an impaired immunity response to SARS-CoV-2, the coronavirus that causes COVID-19, vaccines. Patients currently on glucocorticoids or B-cell depleting therapy appear to have an even more severely impeded vaccine response.

2 Nov 2021

Scientists discover key component of cellular malfunction that contributes to growth of tumors

Scientists have homed in on a crucial step within the sequence of chemical reactions that govern regulation of cell division, proliferation and death, and whose malfunction contributes to the growth of tumors.

2 Nov 2021

COVID-19 and subacute neuropsychiatric symptoms in adolescents

A new paper discusses neurologic symptoms in children with COVID-19.

27 Oct 2021

Air pollution reduces sperm count by causing brain inflammation, mice study shows

Researchers have long known that air pollution can increase the risk of disorders such as obesity, diabetes, and fertility, but they did not know the exact mechanism for how it can lead to these health conditions.

25 Oct 2021

Can targeting autophagy become a new approach to COVID-19 treatment?

In a recent review, the author discusses autophagy as a contributing mechanism of selected drugs that are currently being evaluated to treat COVID‐19.

25 Oct 2021

Targeted drug shows promising activity in kidney cancer patients with brain metastases

A targeted drug has shown promising activity against brain metastases resulting from kidney cancer, achieving a 50 percent response rate, and supporting further studies of the drug in this patient group whose poor prognosis has created a significant unmet need.

21 Oct 2021

Biomarker predicts severity of SARS-CoV-2 infection in patients

A new study investigates a biomarker to predict the severity of disease in patients infected with SARS-CoV-2.

20 Oct 2021

Suggested mechanism of SARS-CoV-2 infection inhibition by Mitoxantrone

A group of researchers performed a drug repurposing screen on an FDA-approved anti-cancer drug named Mitoxantrone.

20 Oct 2021

Kinase News and Research

Clearing old, dysfunctional cells in fat alleviates diabetes

Nanocomputing agent controls the function of protein involved in cell movement, cancer metastasis

Study identifies a host factor that reflects different levels of inflammation within mild COVID-19 cases

Could drugs derived from microalgae be effective against COVID-19?

Study provides a new target for therapeutic intervention in Parkinson's disease

New evidence reveals a cancer-promoting role for MAPK6 enzyme

New method of stem cell transplantation may eliminate the need for radiation or chemotherapy

HSS study provides insight into real-world medication use for treatment of psoriatic arthritis

Study looks at how lupus genetics intersects with COVID-19

Ibrutinib plus standard chemotherapy effective in younger patients with diffuse large B-cell lymphoma

Adaptive immunity in patients infected with SARS-CoV-2 Δ382 Variant

Cycling JAK inhibitors can be effective for treating people with difficult-to-treat rheumatoid arthritis

RA patients taking glucocorticoids or B-cell therapies may have worse COVID-19 vaccine response

Scientists discover key component of cellular malfunction that contributes to growth of tumors

COVID-19 and subacute neuropsychiatric symptoms in adolescents

Air pollution reduces sperm count by causing brain inflammation, mice study shows

Can targeting autophagy become a new approach to COVID-19 treatment?

Targeted drug shows promising activity in kidney cancer patients with brain metastases

Biomarker predicts severity of SARS-CoV-2 infection in patients

Suggested mechanism of SARS-CoV-2 infection inhibition by Mitoxantrone

Measuring Drug-Target Residence Times with Biochemical Assays eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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