Nephropathy News and Research

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Nephropathy is a broad medical term used to denote disease or damage of the kidney, which can eventually result in kidney failure. The primary and most obvious functions of the kidney are to excrete any waste products and to regulate the water and acid-base balance of the body – therefore loss of kidney function is a potentially fatal condition.

Decreased cognitive functioning associated with deterioration in kidney function

Decreased kidney function is associated with decreased cognitive functioning in areas such as global cognitive ability, abstract reasoning and verbal memory, according to a study led by Temple University. This is the first study describing change in multiple domains of cognitive functioning in order to determine which specific abilities are most affected in individuals with impaired renal function.

19 Nov 2012

People with diabetes need a plan to stay healthy during holiday season: Harris Health System

A figurative mine field of savory dishes and desserts await many this holiday season, from pumpkin pies topped with whipped cream, green bean and mushroom casseroles, pork tamales, cranberries and cornbread dressing to fruit salads and oven-roasted turkey.

17 Nov 2012

Cinacalcet failure raises trial conduct issues

The oral calcimimetic agent, cinacalcet, has been found to have no significant effect on cardiovascular events or death in patients with chronic kidney disease in a randomized controlled trial.

16 Nov 2012

Caterpillar fungi may benefit asthma patients

Research shows that cordycepin, extracted from a group of rare parasitic caterpillar fungi of the genus Cordyceps, has unusual anti-inflammatory properties that may make it a good candidate for treating conditions such as asthma and rheumatoid arthritis.

16 Nov 2012

Study links congenital kidney disease with neurodevelopmental disorders

About 10 percent of kids born with kidney defects have large alterations in their genomes known to be linked with neurodevelopmental delay and mental illness, a new study by Columbia University Medical Center (CUMC) researchers has shown.

16 Nov 2012

Peak interest in health issues comes at about age 51 for baby boomers

For baby boomers, the peak interest in health issues comes at about age 51, with a second peak coming near age 65, according to a new study.

16 Nov 2012

Tolvaptan improves kidney health in polycystic kidney disease

A vasopressin V2-receptor blocker slows the increase in total kidney volume and decline in kidney function in patients with autosomal dominant polycystic kidney disease, report US researchers.

12 Nov 2012

CHOP presents new findings on pediatric cardiovascular disease at AHA 2012

Physician-researchers from the Cardiac Center at The Children's Hospital of Philadelphia presented new findings on pediatric cardiovascular disease at the American Heart Association's Scientific Sessions 2012 in Los Angeles.

9 Nov 2012

New communication training could help nephrology fellows to discuss serious news with patients

Kidney specialists, or nephrologists, care for a medically complex population and frequently must discuss serious news with patients: giving a diagnosis of kidney disease, explaining the risks and benefits of treatments, and defining care goals at the end of life. Yet nephrologists do not routinely receive formal education on how to engage in these types of conversations.

9 Nov 2012

Excessive turnover of placental cells may trigger unnatural increase in blood pressure

Excessive turnover of cells in the placenta may trigger an unnatural increase in blood pressure that puts mother and baby at risk, researchers say.

7 Nov 2012

Detailing Medicare's 2013 doc pay schedules: Home health flat, primary care up

Under Medicare's 2013 payment schedule, released late last week, home health agency payments will remain flat while primary care physicians can expect up to a 7 percent boost in payments.

6 Nov 2012

Tengion receives U.S. patent allowance titled ‘Isolated Renal Cells and Uses Thereof’

Tengion, Inc., a leader in regenerative medicine, today announced that the United States Patent and Trademark Office (USPTO) has issued a Notice of Allowance for U.S. Patent Application No. 12/617,721, titled "Isolated Renal Cells and Uses Thereof."

5 Nov 2012

Study highlights potential treatment that reduces kidney growth

Autosomal-dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders, affecting one in every 1,000 people and responsible for up to ten percent of patients on dialysis worldwide. The disease is characterized by the development of cysts that lead to progressive kidney failure and necessitate dialysis or a kidney transplant in most patients aged around fifty. Moreover, the persistent cyst growth causes high blood pressure and painful complications.

5 Nov 2012

New information related to kidney transplantation

Three studies presented during the American Society of Nephrology's Annual Kidney Week provide new information related to kidney transplantation—specifically, the post-transplant health of kidney donors and the racial disparities faced by children in need of transplants.

3 Nov 2012

Tolvaptan shows promise in treating autosomal dominant polycystic kidney disease

A drug therapy shows promise for treating an inherited form of kidney disease called autosomal dominant polycystic kidney disease (ADPKD), Mayo Clinic researchers say.

3 Nov 2012

Genkyotex announces positive results from GKT137831 Phase I studies on healthy subjects

Genkyotex, the leading developer of NOX inhibitors to treat oxygen-radical mediated diseases, announced today that Phase I studies have demonstrated excellent safety and tolerability following single and multiple oral doses of GKT137831, the first in class NOX 1 and 4 inhibitor. In addition, GKT137831 demonstrated a favourable pharmacokinetic profile in these subjects.

3 Nov 2012

Studies provide new information on diet and blood pressure in kidney disease patients

Three studies presented during the American Society of Nephrology's Annual Kidney Week provide new information on diet and blood pressure in kidney disease patients.

3 Nov 2012

State of glycocalyx barrier indicates vascular risk in dialysis patients

The glycocalyx barrier – a mesh of proteoglycans and associated glycosaminoglycans present on vascular endothelium – is impaired in patients with renal failure, probably contributing to their predisposition to endothelial dysfunction and vascular disease, say researchers.

2 Nov 2012

Takeda, Affymax announce data from OMONTYS Phase 3 studies on anemia due to CKD

Affymax, Inc. and Takeda Pharmaceuticals U.S.A., Inc. (TPUSA) today announced the presentation of post-hoc sub-group analyses of the EMERALD Phase 3 studies that evaluated OMONTYS (peginesatide) Injection, an erythropoiesis-stimulating agent (ESA), for the treatment of anemia due to chronic kidney disease (CKD) in adult dialysis patients.

2 Nov 2012

FibroGen announces presentation of FG-4592 Phase 2 data on anemia at ASN Kidney Week 2012

FibroGen, Inc., today announced that two abstracts relating to FG-4592, its oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) clinical candidate for the treatment of anemia in chronic kidney disease, have been accepted for oral and poster presentations at the American Society of Nephrology (ASN) Kidney Week 2012.

1 Nov 2012

Nephropathy News and Research

Further Reading

Decreased cognitive functioning associated with deterioration in kidney function

People with diabetes need a plan to stay healthy during holiday season: Harris Health System

Cinacalcet failure raises trial conduct issues

Caterpillar fungi may benefit asthma patients

Study links congenital kidney disease with neurodevelopmental disorders

Peak interest in health issues comes at about age 51 for baby boomers

Tolvaptan improves kidney health in polycystic kidney disease

CHOP presents new findings on pediatric cardiovascular disease at AHA 2012

New communication training could help nephrology fellows to discuss serious news with patients

Excessive turnover of placental cells may trigger unnatural increase in blood pressure

Detailing Medicare's 2013 doc pay schedules: Home health flat, primary care up

Tengion receives U.S. patent allowance titled ‘Isolated Renal Cells and Uses Thereof’

Study highlights potential treatment that reduces kidney growth

New information related to kidney transplantation

Tolvaptan shows promise in treating autosomal dominant polycystic kidney disease

Genkyotex announces positive results from GKT137831 Phase I studies on healthy subjects

Studies provide new information on diet and blood pressure in kidney disease patients

State of glycocalyx barrier indicates vascular risk in dialysis patients

Takeda, Affymax announce data from OMONTYS Phase 3 studies on anemia due to CKD

FibroGen announces presentation of FG-4592 Phase 2 data on anemia at ASN Kidney Week 2012

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