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New approach shows promise for treating fragile X syndrome

Building on more than two decades of research, a study by MIT neuroscientists at The Picower Institute for Learning and Memory reports a new way to treat pathology and symptoms of fragile X syndrome, the most common genetically-caused autism spectrum disorder.

20 Feb 2025

Mice study offers insight into how the brain balances risk and reward

Every day, our brain makes thousands of decisions, big and small. Any of these decisions - from the least consequential such as picking a restaurant to the more important such as pursuing a different career or moving to a new city - may result in better or worse outcomes.

19 Feb 2025

Genetic mutation linked to schizophrenia in both humans and mice

A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with the same mutation, a rare finding of a direct genetic link to psychosis, report researchers at the University of Illinois Urbana-Champaign and colleagues in Massachusetts and Germany.

19 Feb 2025

Neuroestrogens likely contribute to appetite regulation

Although a woman's ovaries produce the most estrogen, various types of estrogen are also synthesized throughout different tissues in the body, including the brain's neurons.

19 Feb 2025

Direct connection found between memory and sensory processing centers in brain

A newly identified part of a brain circuit mixes sensory information, memories, and emotions to tell whether things are familiar or new—and important or just "background noise."

19 Feb 2025

Nerinetide shows promise in stroke treatment meta-analysis

The Calgary Stroke Program, a joint University of Calgary and Alberta Health Services initiative at Foothills Medical Centre, has been involved with three papers published this week in The Lancet and Lancet Neurology-the ESCAPE-NEXT trial, the FRONTIER trial, and an individual patient-level meta-analysis across three trials.

19 Feb 2025

Cholesterol metabolite linked to Parkinson's disease development in mice

Researchers led by Zhentao Zhang at Wuhan University, China have discovered a cholesterol metabolite that plays a critical role in the development of Parkinson's disease in mice.

18 Feb 2025

SwRI develops computational method to track brain cell development

A team led by Southwest Research Institute (SwRI) developed a computational method to improve techniques to track brain cell development over time.

18 Feb 2025

New review sheds light on links between Alzheimer's and metabolic syndrome

Alzheimer's disease (AD), the most common form of dementia, continues to remain one of modern medicine's greatest challenges.

18 Feb 2025

Researchers identify MLC1 as potential target in multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system caused by the immune system. B cells, which are a type of white blood cell, play a role in the development of MS and are thus a target for therapies.

18 Feb 2025

First insights into familial ALS in Egypt reveal genetic variations and disease progression

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive degeneration of motor neurons, leading to muscle weakness and eventually death.

18 Feb 2025

Researchers discover direct feedback loop in brain circuit connecting memories and emotions

A newly identified part of a brain circuit mixes sensory information, memories, and emotions to tell whether things are familiar or new, and important or just "background noise."

18 Feb 2025

Gene editing shows promise for treating trisomy at cellular level

Gene editing techniques may eventually allow trisomy to be treated at the cellular level, according to an in vitro proof-of-concept study.

18 Feb 2025

Gene therapy breakthrough offers hope for severe Dravet syndrome cases

AAV-Navβ1 gene therapy effectively reduces seizures and prolongs life in a mouse model of SCN1B-linked Dravet syndrome, paving the way for future treatments.

18 Feb 2025

Chronic stress rewires the brain, dulling sound perception

Repeated stress disrupts auditory processing, making sounds seem quieter over time, as shown in a new study on mice.

17 Feb 2025

Pancreatic cancer reprograms nerve cells to fuel growth

Pancreatic cancer is fueled by connections to the nervous system. This is reported by scientists from the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) in their current publication in Nature.

17 Feb 2025