Signaling Pathway News and Research

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Alternate cell growth pathway could open door to new treatments for metastatic cancers

While researchers have a basic understanding of how primary cancer cells grow, less is known about metastasis, the deadly process by which cancers spread.

12 Jul 2019

Study finds new way to enhance regenerative potential of aged intestine

Researchers at the University of Helsinki have discovered how regenerative capacity of intestinal epithelium declines when we age.

11 Jul 2019

New drug combination found to be effective against uveal melanoma in preclinical studies

Uveal melanoma is a very aggressive type of melanoma that affects the eye. It is a rare disorder, affecting an estimated 2,500 people in the United States each year.

8 Jul 2019

Research reveals key cellular mechanism leading to aggressive prostate cancer

Prostate cancer represents a major health challenge and there is currently no effective treatment once it has advanced to the aggressive, metastatic stage.

3 Jul 2019

Promising new approaches in the fight against brain metastasis

Research is currently pursuing several highly promising approaches in the fight against cancers that give rise to metastases in the brain.

28 Jun 2019

Zebrafish offers new clues to regenerating damaged cardiac tissue

Research into the hearts of zebrafish, a pet shop staple marked by their eponymous stripes, has shed light on ways the human heart muscle could be healed following damage.

26 Jun 2019

UAB scientists identify new target for drug intervention in Alzheimer's disease

Scientists at the University of Alabama at Birmingham have identified an enzyme in the brain that may be an intriguing target for interventions against Alzheimer's disease and other dementias.

26 Jun 2019

Switch that decides fate of cells from neural stem cells discovered

Neurons and astrocytes are prominent cell types in the cerebral cortex. Neurons are the primary information processing cells in the brain, whereas astrocytes support and modulate their functions.

24 Jun 2019

Researchers discover redundancies in immune cells

Researchers at ETH Zurich have discovered redundancies in the biochemical signaling pathways of immune cells. This finding has important implications for advances in cancer immunotherapy, among other areas.

18 Jun 2019

Urinary DKK3 can improve prediction of AKI

A new renal biomarker was presented at the ERA-EDTA Congress last year: that shows that urinary DKK3 might help to identify patients who are at risk of progressive chronic kidney disease.

17 Jun 2019

Mutations in fetal genome may contribute to premature birth

Mutations in the gene that codes for SLIT2, a protein expressed in fetal cells in placentas and involved in directing the growth of the fetal nervous system, may contribute to premature births, possibly by activating the mother’s immune system.

From PLOS ONE 14 Jun 2019

Human liver cell protein aids development of malaria parasite, study finds

Researchers in Japan have discovered that the Plasmodium parasites responsible for malaria rely on a human liver cell protein for their development into a form capable of infecting red blood cells and causing disease.

12 Jun 2019

Early life adversity and high levels of FKBP5 protein amplify anxiety-like behavior

Researchers continue to dig for molecular clues to better understand how gene-environment interactions influence neuropsychiatric disease risk and resilience.

11 Jun 2019

Study searches for the origins of depressive symptoms in Huntington's disease

About 40% of the affected patients with Huntington's disease -a neurodegenerative pathology- show depression symptoms, even in early stages before the apparition of the typical motor symptoms of the disease.

31 May 2019

Study sheds light on design of pharmacological strategies to treat depression in Huntington's disease

About 40 % of the affected patients with Huntington's disease -a neurodegenerative pathology- show depression symptoms, even in early stages before the apparition of the typical motor symptoms of the disease.

31 May 2019

Researchers discover signaling protein that may protect parathyroid glands from hyperactivity

Overactive parathyroid glands,which control the body's blood calcium levels, can lead to kidney stones, neuropsychiatric disorders and bone abnormalities, particularly among elderly women.

29 May 2019

UAB study reveals detrimental role of neutrophils in multiple sclerosis

Multiple sclerosis is an autoimmune disease that damages the insulating sheaths of nerve cells of the central nervous system. People with the disease can lose vision, suffer weak limbs, show degenerative symptoms and exhibit impaired cognition.

26 May 2019

Scientists uncover unique set of genes that play a role in muscle cellular gene regulation

York University scientists have uncovered a unique set of genes that play a role in muscle cellular gene expression and differentiation which could lead to new therapeutic targets to prevent the spread of muscle cancer.

23 May 2019

Broccoli contains an ingredient that could target the "Achilles’ heel" of cancers

A new study from the Beth Israel Deaconess Medical Center has come up with a new study that reveals that broccoli, Brussels sprouts, kale, cauliflower, cabbage and collard greens contain a substance that could inactivate a vital gene that plays a role in cancers.

19 May 2019

Certain cancer drugs induce stem cell plasticity in colorectal cancer

Scientists from the German Cancer Research Center and the Mannheim University Medical Center have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signaling pathway in colorectal cancer cells.

16 May 2019