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Sequentia collaborated with Nextbiomics to obtain a novel immunization model against COVID-19

Sequentia Biotech and NextBiomics announced the filing of a patent application for a bacterial vaccine against the COVID-19 syndrome.

From Sequentia Biotech 19 May 2021

Glucosidase inhibitors hold promise as novel therapeutic agents against SARS-CoV-2

In a new study posted to the bioRxiv* preprint server, researchers from the United States report that two iminosugar glucosidase inhibitors have the ability to suppress the replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in tissue culture – at concentrations of at least 100 times lower than required for cytotoxic effects.

19 May 2021

Lengthy treatment with low-dose 6-mercaptopurine inhibits resistant triple-negative breast cancer cells

The cover for issue 7 of Oncotarget features Figure 5, "SUM149-MA cells surviving a 6-MP treatment are sensitive to chemotherapeutic drugs," published in "Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine" by Singh, et al. which reported that the authors have reported that a lengthy treatment with low-dose 6-mercaptopurine, a clinically useful anti-inflammatory drug, inhibits such resistant cells.

19 May 2021

Study provides an overview of neonatal withdrawal signs following late in utero exposure to SSRIs

Neonatal withdrawal signs have been documented in newborns of mothers treated with antidepressants and are known as a cause of neonatal morbidity.

19 May 2021

New mathematical model predicts how bacterial mutations influence the success of antibiotic treatments

Scientists have developed a mathematical model that predicts how the number and effects of bacterial mutations leading to drug resistance will influence the success of antibiotic treatments.

19 May 2021

Combination approach can improve the success rate of cancer treatment

A new cancer vaccine could boost the positive effects of existing immunotherapy drugs, improving the success rate of treatments from 20% to 75% of cases, according to a new study by immunologists from the University of Konstanz.

19 May 2021

New therapeutic strategy can prevent dental decay in children

The combination of a carb-heavy diet and poor oral hygiene can leave children with early childhood caries (ECC), a severe form of dental decay that can have a lasting impact on their oral and overall health.

19 May 2021

Expert panel provides guidance for optimized design of early drug trials for Alzheimer's, related dementias

An expert panel convened by the Alzheimer's Drug Discovery Foundation (ADDF) and The Association for Frontotemporal Degeneration (AFTD) provides guidance on best practices for the design of early drug trials for Alzheimer's disease, frontotemporal degeneration (FTD), and other neurodegenerative dementias.

19 May 2021

Connecticut's MAT programs have higher-than-average patient retention rates

Medication-assisted treatment, or MAT, is an important tool in the ongoing fight against opioid use dependence in the United States.

19 May 2021

Scientists develop experimental direct-acting antiviral therapy to treat COVID-19

An international team of scientists from the Menzies Health Institute Queensland (MHIQ) at Griffith University and from City of Hope, a research and treatment center for cancer, diabetes and other life-threatening diseases in the U.S., have developed an experimental direct-acting antiviral therapy to treat COVID-19.

18 May 2021

Higher levels of inflammatory proteins in the blood are associated with aggressive traits

Aggression is common in many neuropsychiatric diseases, such as dementia, autism spectrum disorder, and schizophrenia.

18 May 2021

Medications commonly prescribed for schizophrenia linked to cognitive impairment

Writing in the May 14, 2021 issue of The American Journal of Psychiatry, a multi-institution team of scientists led by researchers at University of California San Diego School of Medicine report that medications commonly prescribed to reduce the severity of physical and mental health symptoms associated with schizophrenia may have a cumulative effect of worsening cognitive function in patients.

18 May 2021

Study provides new basis to compare the effectiveness of different tuberculosis treatments

A new study published in Nature Communications provides an important new basis for comparing the effectiveness of different tuberculosis treatments.

18 May 2021

ErbB inhibitor lapatinib exhibits potent anti-SARS-CoV-2 activity

A team of scientists from the USA and Belgium has recently revealed that the ErbB family of receptor tyrosine kinases play a vital role in regulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lifecycle in host cells and that inhibition of these receptors can protect against SARS-CoV-2-induced acute and chronic lung injuries and inflammation.

18 May 2021

Researchers investigate immune molecule that helps protect transplanted kidneys

Looking to improve organ transplant success, researchers are working to learn more about how an immune molecule, which also protects a fetus, helps protect some transplanted kidneys, and to develop a synthetic version of that molecule that could help more patients.

18 May 2021

Type of heart failure may influence which approach is optimal for patients with AFib

Among patients with both heart failure and atrial fibrillation (AFib), treatment strategies focused on controlling the heart rhythm (using catheter ablation) and those focused on controlling the heart rate (using drugs and/or a pacemaker) showed no significant differences in terms of death from any cause or progression of heart failure.

18 May 2021

Sotagliflozin reduces adverse cardiovascular events across patients with diabetes, heart failure

Patients with both diabetes and heart failure who were treated with sotagliflozin, a novel investigational drug for diabetes, for a median of nine to 16 months experienced reductions of 22% to 43% in the risk of death or worsening heart failure compared with similar patients who were treated with a placebo

18 May 2021

A potential treatment to prevent obesity-related liver damage

One of the especially dangerous health risks of being extremely overweight occurs when an obese person begins to accumulate fat in their liver.

18 May 2021

New technology tricks tumors to eliminate itself through the production of anti-cancer agents

Scientists at the University of Zurich have modified a common respiratory virus, called adenovirus, to act like a Trojan horse to deliver genes for cancer therapeutics directly into tumor cells. Unlike chemotherapy or radiotherapy, this approach does no harm to normal healthy cells.

18 May 2021

Cancer patients without health insurance had significantly worse survival than Medicare beneficiaries

MUSC Hollings Cancer Center lung cancer researcher Gerard Silvestri, M.D., found that a lack of insurance leads to worse cancer survival than for those with Medicare, in a paper published in the May issue of Health Affairs.

17 May 2021

Drugs News and Research

Sequentia collaborated with Nextbiomics to obtain a novel immunization model against COVID-19

Glucosidase inhibitors hold promise as novel therapeutic agents against SARS-CoV-2

Lengthy treatment with low-dose 6-mercaptopurine inhibits resistant triple-negative breast cancer cells

Study provides an overview of neonatal withdrawal signs following late in utero exposure to SSRIs

New mathematical model predicts how bacterial mutations influence the success of antibiotic treatments

Combination approach can improve the success rate of cancer treatment

New therapeutic strategy can prevent dental decay in children

Expert panel provides guidance for optimized design of early drug trials for Alzheimer's, related dementias

Connecticut's MAT programs have higher-than-average patient retention rates

Scientists develop experimental direct-acting antiviral therapy to treat COVID-19

Higher levels of inflammatory proteins in the blood are associated with aggressive traits

Medications commonly prescribed for schizophrenia linked to cognitive impairment

Study provides new basis to compare the effectiveness of different tuberculosis treatments

ErbB inhibitor lapatinib exhibits potent anti-SARS-CoV-2 activity

Researchers investigate immune molecule that helps protect transplanted kidneys

Type of heart failure may influence which approach is optimal for patients with AFib

Sotagliflozin reduces adverse cardiovascular events across patients with diabetes, heart failure

A potential treatment to prevent obesity-related liver damage

New technology tricks tumors to eliminate itself through the production of anti-cancer agents

Cancer patients without health insurance had significantly worse survival than Medicare beneficiaries

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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