Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Disrupting genes in the yeast Pichia pastori to increase its secretory production of useful proteins

A collaboration including researchers from Kobe University, University of Tokyo and Tohoku University has successfully identified and disrupted genes in the yeast Pichia pastoris (1) in order to increase its secretory production of useful proteins (2).

8 Jul 2022

Characterization of longer-term effects on behavior and brain inflammation following recovery from mild COVID-19

A recent study reported that long COVID in mice causes brain inflammation and cognitive impairment.

8 Jul 2022

The replicative ability and pathogenicity of Omicron BA.4 and BA.5 isolates in hamsters

Researchers characterized the clinical isolates of SARS-CoV-2 Omicron BA.4 and BA.5.

8 Jul 2022

Study suggests spironolactone may improve clinical outcomes in COVID-19

Researchers performed an integrative analysis of clinical outcomes and viral entry networks in severe COVID-19 infection.

8 Jul 2022

Immunogenicity and safety of the protein-based heterodimer booster vaccine for COVID-19

Researchers compared the immunogenicity and safety of the protein-based heterodimer vaccine (PHH-1V) and BNT162b2 COVID-19 vaccines.

8 Jul 2022

The strength and breadth of antibody responses elicited by hybrid immunity to COVID-19 vaccination or infection alone

Researchers assessed neutralizing antibody responses to SARS-CoV-2 after receiving one dose of vaccine.

8 Jul 2022

Rare Cells Capable of Transforming into Leukemia may Provide new Insight into Leukemic Landscape

In our latest interview, News Medical speaks to Adam G. Schrum, PhD, Associate Professor of Molecular Microbiology & Immunology and Surgery at the University of Missouri, about how dysfunction in an unusual type of thymocyte cell may develop into leukemia in some patients.

8 Jul 2022

Nanoparticle vaccine could protect against animal viruses including future SARS-CoV-2 variants

A recent study published in the Science journal depicted that mosaic receptor-binding domain (RBD) nanoparticles immunize from diverse sarbecovirus challenges, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), among animal models.

8 Jul 2022

Discovery of multiple new SARS-CoV-2 MPro inhibitors

In a recent study posted to the bioRxiv* preprint server, researchers performed an extensive library docking for new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) covalent and non-covalent inhibitors.

8 Jul 2022

Diabetes not strongly associated with in-hospital COVID mortality

In a recent study posted to the medRxiv* preprint server, researchers assessed the association between diabetes mellitus (type 2 diabetes) and mortality among patients hospitalized with coronavirus disease 2019 (COVID-19) at multiple centers in Canada and Denmark.

8 Jul 2022

Antibodies transmitted through breast milk persist six months after COVID mRNA vaccination

Researchers describe the effects of COVID-19 vaccines in lactating mothers and relates their antibody response to the protection of their children.

7 Jul 2022

After 3 doses of COVID vaccine, most cancer patients retain detectable humoral immunity

In a recent study posted to the medRxiv* preprint server, researchers assessed the efficacy and durability of immune responses to the third dose of coronavirus disease 2019 (COVID-19) vaccines. They also assessed the efficacy of the fourth vaccine dose among severely immunocompromised patients with hematological malignancies.

7 Jul 2022

Scientists identify molecules promoting plant immunity

Two studies published by researchers at the Max Planck Institute for Plant Breeding Research in Cologne, Germany in collaboration with colleagues in China have discovered natural cellular molecules that drive critical plant immune responses.

7 Jul 2022

Researchers unravel mechanism that underlies failure of staph vaccine trials

For the most part, the bacterium Staphylococcus aureus is common and harmless, posing no threat to humans with whom they coexist.

7 Jul 2022

Novel COVID-19 antibody delivery approach advances to clinical trials

Under a Defense Advanced Research Projects Agency (DARPA) and Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND) funded program, a novel COVID-19 antibody delivery approach has advanced to clinical trials.

7 Jul 2022

New biosensor system derived from E. coli bacteria could accelerate drug development

For more affordable, sustainable drug options than we have today, the medication we take to treat high blood pressure, pain or memory loss may one day come from engineered bacteria, cultured in a vat like yogurt.

7 Jul 2022

Knowledge of HIV Pol polyprotein's structure could spur the development of new therapies

In a discovery that could spur the development of new therapies for more than 40 million HIV patients worldwide, scientists from Rutgers University and the Salk Institute determined the molecular structure of the HIV Pol polyprotein, a protein that plays a critical role in helping the virus propagate itself and spread throughout the body.

7 Jul 2022

Novel gene-based therapies for sickle cell disease rely on finding the right mouse for the job

Sickle cell disease is an extremely debilitating condition that affects up to 40% of the population in African countries, with patients suffering episodes of excruciating pain, organ damage and reduced life-expectancy.

7 Jul 2022

Broadness of neutralizing antibodies to sarbecoviruses depends on priming conditions

In a recent study under review at the Nature Portfolio journal and currently available on the Research Square* preprint server, researchers identified immune priming conditions that generated broadly neutralizing antibody (nAb) responses and assessed immunity post-third dose of coronavirus disease 2019 (COVID-19) vaccines such as BNT126b2 or Coronavac vaccines after two homologous doses of BNT126b2 or Coronavac vaccines.

7 Jul 2022

TRIM7 inhibits coxsackievirus and norovirus infection

In a recent study posted to the bioRxiv* preprint server, researchers elucidated the underlying mechanisms of tripartite motif containing 7 (TRIM7) activity against coxsackievirus and norovirus.

7 Jul 2022

Protein News and Research

Further Reading

Disrupting genes in the yeast Pichia pastori to increase its secretory production of useful proteins

Characterization of longer-term effects on behavior and brain inflammation following recovery from mild COVID-19

The replicative ability and pathogenicity of Omicron BA.4 and BA.5 isolates in hamsters

Study suggests spironolactone may improve clinical outcomes in COVID-19

Immunogenicity and safety of the protein-based heterodimer booster vaccine for COVID-19

The strength and breadth of antibody responses elicited by hybrid immunity to COVID-19 vaccination or infection alone

Rare Cells Capable of Transforming into Leukemia may Provide new Insight into Leukemic Landscape

Nanoparticle vaccine could protect against animal viruses including future SARS-CoV-2 variants

Discovery of multiple new SARS-CoV-2 MPro inhibitors

Diabetes not strongly associated with in-hospital COVID mortality

Antibodies transmitted through breast milk persist six months after COVID mRNA vaccination

After 3 doses of COVID vaccine, most cancer patients retain detectable humoral immunity

Scientists identify molecules promoting plant immunity

Researchers unravel mechanism that underlies failure of staph vaccine trials

Novel COVID-19 antibody delivery approach advances to clinical trials

New biosensor system derived from E. coli bacteria could accelerate drug development

Knowledge of HIV Pol polyprotein's structure could spur the development of new therapies

Novel gene-based therapies for sickle cell disease rely on finding the right mouse for the job

Broadness of neutralizing antibodies to sarbecoviruses depends on priming conditions

TRIM7 inhibits coxsackievirus and norovirus infection

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