Immune System News and Research

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Seattle Children’s opens first clinical trial to study IBD and GVHD in pediatric patients

In an effort to find new strategies to personalize treatment for pediatric patients, Seattle Children's has opened the first clinical trial applying next-generation T-cell receptor sequencing and single-cell gene expression analysis to better understand how the immune system drives both inflammatory bowel disease in pediatric autoimmunity patients and graft-versus host disease in pediatric bone marrow transplant patients.

From 10x Genomics, Inc. 23 May 2017

FAU researchers use robot technology to gain insights into development of malignant melanoma

Malignant melanoma is one of the most common and dangerous types of cancer. Researchers at Friedrich-Alexander Universität Erlangen-Nürnberg investigated how and why brown pigmented moles turn into malignant melanoma using innovative robot technology.

23 May 2017

Experimental treatment tempers HLH, MS symptoms in mouse models, study shows

Immune diseases like multiple sclerosis and hemophagocytic lymphohistiocytosis unleash destructive waves of inflammation on the body, causing death or a lifetime of illness and physical impairment.

23 May 2017

Researchers identify small RNA molecule that promotes deadly forms of breast cancer

Researchers from Princeton University's Department of Molecular Biology have identified a small RNA molecule that helps maintain the activity of stem cells in both healthy and cancerous breast tissue.

23 May 2017

Study identifies two T cell biomarkers that may predict survival trajectory of IPF patients

Two T cell biomarkers appear to predict the survival trajectory of patients with idiopathic pulmonary fibrosis (IPF), a lung disease that has a varied, but ultimately devastating, impact on patients, according to new research presented at the ATS 2017 International Conference.

22 May 2017

Rush clinical trial offers new immunotherapy combination to patients fighting kidney cancer

Rush University Medical Center is among the first hospitals in the nation, and the only one in Illinois, to provide patients fighting advanced kidney access to a new combination immunotherapy that targets different immune system cells and processes than a widely used therapy that has been proven effective for some patients but had little effect on others.

22 May 2017

Cedars-Sinai researchers analyze social media posts to find medication concerns of IBD patients

Cedars-Sinai researchers analyzed thousands of social media posts to determine the biggest concerns patients with inflammatory bowel disease (IBD) have about their prescribed treatments.

22 May 2017

Are sunscreens giving us the protection we need?

The harmful effects of the sun's ultraviolet (UV) rays are well publicised and the risk of developing skin cancer has scared many people into using a sunscreen product to protect their skin when exposed to the sun. However, a recent test of the performance of a range of marketed sun protection products revealed that many of them fail to provide adequate protection against UV rays.

19 May 2017

New clinical trial offers hope for patients with hard-to-treat cancer caused by asbestos

Patients with a hard-to-treat type of cancer are being given new hope in a ground-breaking clinical trial. Researchers at the University of Southampton and the University of Leicester are trialing a drug that could boost the body's immune system to fight off mesothelioma, which can be caused by asbestos.

19 May 2017

Researchers discover how the injured brain alerts immune system

Johns Hopkins researchers say they have identified a new way that cells in the brain alert the rest of the body to recruit immune cells when the brain is injured. The work was completed in mouse models that mimic infection, stroke or trauma in humans.

18 May 2017

Research into cellular senescence may lead to new ways of treating age-related disorders

One of the things that happens to our bodies as we age is that certain cells start to accumulate. So-called senescent cells – cells that "retire" and stop dividing but refuse to die – are always present, and they even serve some important functions, such as in wound repair.

18 May 2017

FDA-approved drug improves clinical outcomes among patients with rare immunologic disease

Adding the injectable drug mepolizumab to standard treatment for eosinophilic granulomatosis with polyangiitis (EGPA), a rare immunologic disease, significantly improved clinical outcomes among participants in an advanced clinical trial, scientists report.

18 May 2017

Researchers show how cancer therapy works in different way to destroy tumor cells

Antibodies to the proteins PD-1 and PD-L1 have been shown to fight cancer by unleashing the body's T cells, a type of immune cell.

18 May 2017

New finding could lead to more effective treatment decisions for younger colorectal cancer patients

Younger colon cancer patients appear to have more than three times as many mutations in their tumors as older patients, which could lead to more effective treatment decisions, say researchers at Georgetown Lombardi Comprehensive Cancer Center.

18 May 2017

Tumor mutation load in patient's biopsy varies by age and type of cancer

A team of investigators led by researchers at Georgetown Lombardi Comprehensive Cancer Center has found that the tumor mutation load, or TML, in a patient's cancer biopsy varied by age and the type of cancer, along with several other factors.

18 May 2017

Microbes can manipulate molecular machinery of host cells to influence health

All animals -- from sea sponges to modern-day humans -- evolved in a world already teeming with microbes. These single-celled microorganisms now cover practically every surface of our bodies and are as much a part of our biology as our own tissues and organs.

17 May 2017

Researchers develop new strategy that can revolutionize HIV vaccine design

Vaccines are an essential tool for preventing and treating serious infectious diseases such as polio, chicken pox and measles. But so far it has not been possible to develop vaccines capable of contributing to the treatment and prevention of chronic infectious diseases such as HIV and hepatitis C.

17 May 2017

Researchers develop new test for rapid and reliable diagnosis of sepsis

Researchers have developed a test that can rapidly and reliably diagnose sepsis, a potentially life-threatening complication of bacterial infections.

17 May 2017

Experimental gene therapy proven safe for preserving vision of people with AMD

In a small and preliminary clinical trial, Johns Hopkins researchers and their collaborators have shown that an experimental gene therapy that uses viruses to introduce a therapeutic gene into the eye is safe and that it may be effective in preserving the vision of people with wet age-related macular degeneration.

17 May 2017

Major allergens strongly underrepresented in some immunotherapy against bee stings

Summer is approaching, and for many allergy sufferers this means it is time to start fearing bee stings. "Allergic reactions to insect venoms are potentially life-threatening, and constitute one of the most severe hypersensitivity reactions," explains PD Dr. Simon Blank, research group leader at the Center of Allergy & Environment, a joint undertaking by the Helmholtz Zentrum München and the TUM.

17 May 2017

Immune System News and Research

Seattle Children’s opens first clinical trial to study IBD and GVHD in pediatric patients

FAU researchers use robot technology to gain insights into development of malignant melanoma

Experimental treatment tempers HLH, MS symptoms in mouse models, study shows

Researchers identify small RNA molecule that promotes deadly forms of breast cancer

Study identifies two T cell biomarkers that may predict survival trajectory of IPF patients

Rush clinical trial offers new immunotherapy combination to patients fighting kidney cancer

Cedars-Sinai researchers analyze social media posts to find medication concerns of IBD patients

Are sunscreens giving us the protection we need?

New clinical trial offers hope for patients with hard-to-treat cancer caused by asbestos

Researchers discover how the injured brain alerts immune system

Research into cellular senescence may lead to new ways of treating age-related disorders

FDA-approved drug improves clinical outcomes among patients with rare immunologic disease

Researchers show how cancer therapy works in different way to destroy tumor cells

New finding could lead to more effective treatment decisions for younger colorectal cancer patients

Tumor mutation load in patient's biopsy varies by age and type of cancer

Microbes can manipulate molecular machinery of host cells to influence health

Researchers develop new strategy that can revolutionize HIV vaccine design

Researchers develop new test for rapid and reliable diagnosis of sepsis

Experimental gene therapy proven safe for preserving vision of people with AMD

Major allergens strongly underrepresented in some immunotherapy against bee stings

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