Infectious Diseases News and Research

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Nymox second-quarter net loss increases to $1.75 million

Nymox Pharmaceutical Corporation announced today its financial results for the second quarter of 2010. Nymox reported a net loss of $1,745,798, or $0.05 per share for the quarter and $3,015,348, or $0.10 per share for the six months ending June 30, 2010, compared to $1,220,152, or $0.04 per share for the quarter and $2,224,411, or $0.07 per share for the six months ending June 30, 2009. Net losses include stock compensation charges for the quarter of $245,245 in 2010 and $248,886 in 2009 and for the six months ending June 30 of $440,465 in 2010 and $558,536 in 2009.

16 Aug 2010

Mathematical model projects potential impact of current tools fighting malaria in Africa

Current tools for combating malaria, such as artemisinin-based combination therapy (ACT) and increasing coverage of long-lasting insecticide treated nets (LLINs) insecticide-treated bednets (ITN) "could dramatically reduce the burden of malignant malaria on parts of Africa if a comprehensive, sustained intervention programme were in place," according to a study published this week in PLoS Medicine, CORDIS News reports.

16 Aug 2010

Common genetic variation in HLA region associated with late-onset sporadic Parkinson's disease: Research

A team of researchers has discovered new evidence that Parkinson's disease may have an infectious or autoimmune origin. "Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease" appears online in Nature Genetics.

16 Aug 2010

Trubion Pharmaceuticals signs definitive merger agreement with Emergent BioSolutions

Trubion Pharmaceuticals, Inc. today announced the signing of a definitive merger agreement with Emergent BioSolutions Inc., in which Emergent has agreed to acquire Trubion. Under the terms of the agreement, each share of Trubion common stock will be converted into the right to receive an upfront payment of $1.365 per share in cash and 0.1641 shares of Emergent BioSolutions common stock.

13 Aug 2010

Achillion second-quarter net loss increases to $6.4 million

Achillion Pharmaceuticals, Inc., a leader in the discovery and development of small molecule drugs to combat the most challenging infectious diseases, today reported financial results for the three and six months ended June 30, 2010. For the second quarter of 2010, the Company reported a net loss of $6.4 million, compared with a net loss of $6.1 million for the same period last year. Cash, cash equivalents and marketable securities as of June 30, 2010 were $19.5 million.

13 Aug 2010

Floods: U.N. issues $459.7M appeal for Pakistan, China concerned about disease outbreaks after mudslides

The U.N. appealed for $459.7 million on Wednesday "to aid flood victims in Pakistan as the magnitude of the disaster widened, with about one-fifth of the country submerged and the annual monsoon season still potent," the New York Times reports (MacFarquhar, 8/11).

13 Aug 2010

A*STAR's Singapore Immunology Network, Institut M-rieux and bioM-rieux partner in TB research

An investment of S$3 million is being pumped into tuberculosis (TB) research by A*STAR's Singapore Immunology Network (SIgN), bioindustrial group Institut M-rieux and its in vitro diagnostics company bioM-rieux. The project, which involves setting up a joint laboratory in Biopolis, Singapore aims to investigate and identify novel biomarkers that could allow early identification of individuals at risk of TB disease development and disease reactivation. This could lead to better diagnosis and treatment for the highly contagious disease.

13 Aug 2010

Severe inflammatory response to initial UTI causes bladder damage: Research

The immune system may open the door to recurrent urinary tract infections (UTIs) by overdoing its response to an initial infection, researchers at Washington University School of Medicine in St. Louis have found.Researchers showed in mice that severe inflammatory responses to an initial UTI cause bladder damage and allow infection to persist longer. After one to two weeks of infection, the bladder wall undergoes additional changes that leave mice more vulnerable to later infection. Suppressing the immune system during initial infection decreases these vulnerabilities, they report Aug. 12 in PLoS Pathogens.

13 Aug 2010

WHO releases H1N1 Emergency Committee roster

Five of the 15 experts advising the WHO on H1N1 (swine flu) had ties to the pharmaceutical industry, "including for flu vaccine research," according to the Emergency Committee members' list released by the agency Wednesday, Agence France-Presse reports.

13 Aug 2010

Emergent BioSolutions enters agreement to acquire Trubion Pharmaceuticals

Emergent BioSolutions Inc. announced today it has entered into a definitive agreement to acquire Trubion Pharmaceuticals, Inc. for upfront consideration of $96.8 million of value and up to $38.7 million of success-based milestones, resulting in a total consideration of up to $135.5 million. The acquisition will diversify Emergent's product development pipeline with the addition of Trubion's two clinical-stage product candidates focused on the targeted disease areas of oncology and autoimmunity.

13 Aug 2010

Superbug purportedly from Asia on the rise in UK & Australia

British scientists have claimed that a new gene called New Delhi metallo-beta-lactamase, or NDM-1 has emerged that makes the bacteria resistant to almost all antibiotics. India has rejected the claim that it is the source of this superbug. Cases have been detected in the UK and Australia and are on the rise in the UK.

12 Aug 2010

Newly identified gene enabling bacterial resistance to most antibiotics found in South Asia, U.K., study finds

A study published online Wednesday in Lancet Infectious Diseases identifies a gene that enables bacteria to resist most antibiotics and calls for better global surveillance of multi-drug resistant bacteria, the Associated Press reports (8/11).

12 Aug 2010

Tengion announces clinical, corporate and second-quarter financial updates

Tengion Inc. today provided a corporate and product development update and reported its financial results for the quarter ended June 30, 2010.

12 Aug 2010

Elsevier launches Malaria Nexus resource to benefit malaria researchers worldwide

Elsevier, the world-leading publisher of scientific, technical and medical information products and services, today announced the launch of Malaria Nexus, Elsevier's Global Malaria Resource. Malaria Nexus highlights the latest published research in Malaria, utilizing Elsevier's leading journals in Parasitology, Entomology and Tropical Medicine, including The Lancet-, The Lancet Infectious Diseases, Transactions of the Royal Society of Tropical Medicine and Hygiene, and International Journal for Parasitology.

12 Aug 2010

Human Immune Phenotyping Centers to receive NIAID grants for research

A new nationwide research initiative has been launched to define changes in the human immune system, using human and not animal studies, in response to infection or to vaccination. Six U. S.-based Human Immune Phenotyping Centers will receive a total of $100 million over five years to conduct this research.Funding for the centers is provided by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. Support for the first year of this initiative will come from the American Recovery and Reinvestment Act.

12 Aug 2010

Einstein College receives grant to develop stem cell-based therapies

Scientists at Albert Einstein College of Medicine of Yeshiva University have received a five-year, $10.8 million grant to develop stem cell-based therapies that could be used to mitigate radiation-induced gastrointestinal syndrome - part of acute radiation syndrome (ARS) - for military personnel, first responders and the general public. The Einstein research, funded by the federal Centers for Medical Countermeasures Against Radiation, is part of a program coordinated by the National Institute of Allergy and Infectious Diseases.

12 Aug 2010

Chimpanzee adenoviruses can be used as vaccine vectors: Research

In recent years, scientists have studied the possibility of using engineered human adenoviruses as vaccines against diseases such as HIV, tuberculosis, and malaria. In this approach, adenoviruses, which commonly cause respiratory-tract infections, are rendered relatively harmless before they are used as vectors to deliver genes from pathogens, which in turn stimulate the body to generate a protective immune response.

12 Aug 2010

Elsevier launches Global Malaria Resource

11 Aug 2010

PolyMedix's PMX-60056 Phase 1B/2 dose-ranging clinical study for heparin reversal meets study endpoints

PolyMedix, Inc., an emerging biotechnology company focused on developing new therapeutic drugs to treat acute cardiovascular disorders and infectious diseases, has successfully completed a Phase 1B/2 dose-ranging clinical study with PMX-60056, a synthetic small-molecule designed to reverse heparin and low molecular weight heparin anticoagulants.

11 Aug 2010

Rxi Pharmaceuticals second-quarter net loss decreases to $2.1 million

RXi Pharmaceuticals Corporation, a recognized leader in RNAi-based therapeutic discovery and development, today reported its financial results for the second quarter ended June 30, 2010.

11 Aug 2010

Infectious Diseases News and Research

Nymox second-quarter net loss increases to $1.75 million

Mathematical model projects potential impact of current tools fighting malaria in Africa

Common genetic variation in HLA region associated with late-onset sporadic Parkinson's disease: Research

Trubion Pharmaceuticals signs definitive merger agreement with Emergent BioSolutions

Achillion second-quarter net loss increases to $6.4 million

Floods: U.N. issues $459.7M appeal for Pakistan, China concerned about disease outbreaks after mudslides

A*STAR's Singapore Immunology Network, Institut M-rieux and bioM-rieux partner in TB research

Severe inflammatory response to initial UTI causes bladder damage: Research

WHO releases H1N1 Emergency Committee roster

Emergent BioSolutions enters agreement to acquire Trubion Pharmaceuticals

Superbug purportedly from Asia on the rise in UK & Australia

Newly identified gene enabling bacterial resistance to most antibiotics found in South Asia, U.K., study finds

Tengion announces clinical, corporate and second-quarter financial updates

Elsevier launches Malaria Nexus resource to benefit malaria researchers worldwide

Human Immune Phenotyping Centers to receive NIAID grants for research

Einstein College receives grant to develop stem cell-based therapies

Chimpanzee adenoviruses can be used as vaccine vectors: Research

Elsevier launches Global Malaria Resource

PolyMedix's PMX-60056 Phase 1B/2 dose-ranging clinical study for heparin reversal meets study endpoints

Rxi Pharmaceuticals second-quarter net loss decreases to $2.1 million

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