Placebo News and Research

RSS

Lack of direct comparisons prevents assessment of upadacitinib's benefit in Crohn's disease

Like several immunosuppressive biologics, the JAK inhibitor upadacitinib is also approved for the treatment of Crohn's disease. Commissioned by the Federal Joint Committee (G-BA), the Institute for Quality and Efficiency in Health Care (IQWiG) has now investigated in an early benefit assessment whether the drug offers an added benefit versus the appropriate comparator therapy to patients with moderate to severe active Crohn's disease who have had an inadequate response, lost response or are intolerant to conventional therapy or a biologic agent.

25 Oct 2023

Perioperative durvalumab may change standard-of-care for patients with resectable lung cancer

A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to results of a Phase III trial reported by researchers at The University of Texas MD Anderson Cancer Center.

24 Oct 2023

Intranasal vaccination: A potent one-time solution for comprehensive COVID-19 immunity

A single-dose intranasal vaccine effectively induces robust immune responses.

24 Oct 2023

Groundbreaking study reveals most effective adjunctive drug for Parkinson's disease

The efficacy, tolerability, and safety of various anti-Parkinson's drugs.

23 Oct 2023

Can strawberries mitigate Alzheimer's risk? Recent study suggests a possibility

Whether strawberry supplementation mitigates the risk for late-life dementia.

23 Oct 2023

Perioperative immunotherapy improves event-free survival in resectable early-stage lung cancer

Compared with pre-surgical (neoadjuvant) chemotherapy alone, adding perioperative immunotherapy – given before and after surgery – significantly improved event-free survival (EFS) in patients with resectable early-stage non-small cell lung cancer (NSCLC).

22 Oct 2023

Dual-action drug produces shows promising results in neuroendocrine tumor trial

A drug that simultaneously strikes cancer cells' growth circuits and pipeline to the bloodstream produced encouraging results in a clinical trial involving patients with advanced neuroendocrine tumors, according to a study led by Dana-Farber Cancer Institute investigators.

22 Oct 2023

Everolimus after surgery may benefit patients with very-high-risk clear cell renal cell carcinoma

A secondary analysis from the SWOG S0931 EVEREST trial has found that in the subgroup of patients with clear-cell renal cell carcinoma (RCC) who were at very-high risk of recurrence, those who were treated with everolimus after surgery had a statistically significant improvement in recurrence-free survival compared to patients getting placebo after surgery.

22 Oct 2023

Clinical study evaluates safety and efficacy of methylone in patients with severe PTSD

Clerkenwell Health, the modern mental health company specializing in matching patients with cutting-edge psychiatry treatments, today announced that it is taking part in Transcend Therapeutics’ Phase 2 study evaluating the safety and efficacy of methylone in patients with severe PTSD.

20 Oct 2023

Study finds more mature gut microbiome in malnourished Nigerien children after antibiotic treatment

Malnutrition threatens the lives of millions of children under age 5, causing about 500,000 deaths per year in low- and middle-income countries.

19 Oct 2023

Can selenium and vitamin E supplementation prevent recurrence and progression of non–muscle-invasive bladder cancer?

The use of vitamin E and selenium in preventing the recurrence and progression of NMIBC.

19 Oct 2023

More antibiotics not better for preventing infection after joint replacement surgery, study finds

Knee and hip replacements are increasing globally due to an aging population. In the United States, the number of patients needing a joint replacement will exceed 2.7 million in the next 7 years.

18 Oct 2023

New treatment options offer hope for patients with non-small cell lung cancer

More people with non-small cell lung cancer (NSCLC) are likely to benefit from new drugs that target molecular alterations in tumour cells, with less need for chemotherapy, following results of multiple landmark clinical trials reported for the first time in late-breaking presentations at the ESMO Congress 2023 (1-7).

17 Oct 2023

Late-breaking studies could change the treatment landscape for women with gynecological cancers

Results from highly anticipated phase 3 clinical trials in gynecological cancers with, among others, new data that cover the entire spectrum of managing patients with cervical cancer, will be presented at the ESMO Congress 2023 in Madrid, Spain.

17 Oct 2023

Oral diabetes and obesity meds danuglipron and orforglipron show promise but have gastrointestinal drawbacks

New orally-administered GLP-1 receptor agonists danuglipron and orforglipron show promise in treating type 2 diabetes and obesity, according to a systematic review. While effective in glycemic control and weight reduction, these drugs come with gastrointestinal side effects that may lead to treatment discontinuation.

17 Oct 2023

Tirzepatide boosts weight loss in lifestyle intervention patients, but comes with a catch

In a groundbreaking 84-week-long study, researchers found that tirzepatide, a medication initially designed for treating type 2 diabetes, significantly bolstered weight loss in overweight and obese patients already on intensive lifestyle programs. While the drug showed promise in further reducing body weight and improving cardiometabolic factors, mild to moderate gastrointestinal side effects were the most common drawback.

16 Oct 2023

Can creatine and resistance training trim your body fat percentage?

Study reveals that resistance training combined with creatine supplementation effectively reduces body fat percentage in adults under 50 without affecting absolute fat mass. Findings are consistent across variables like age, BMI, and exercise frequency, suggesting a uniform impact.

16 Oct 2023

Widely available prescription drug can improve IBS symptoms

A cheap and widely available prescription drug can improve symptoms of irritable bowel syndrome in patients seen in GP surgeries, new research presented today at UEG Week 2023 has found.

16 Oct 2023

Can herbal remedies, spices, and dietary fibers offer effective treatment options for children with irritable bowel syndrome (IBS)?

The positive effects and adverse reactions of spices, dietary fiber, and medicinal herbs for pediatric patients with IBS.

16 Oct 2023

Two simple solutions could help prevent postpartum hemorrhage

Two simple solutions could help prevent severe bleeding (postpartum hemorrhage) after cesarean delivery, suggests research presented at the ANESTHESIOLOGY® 2023 annual meeting.

15 Oct 2023

Placebo News and Research

Lack of direct comparisons prevents assessment of upadacitinib's benefit in Crohn's disease

Perioperative durvalumab may change standard-of-care for patients with resectable lung cancer

Intranasal vaccination: A potent one-time solution for comprehensive COVID-19 immunity

Groundbreaking study reveals most effective adjunctive drug for Parkinson's disease

Can strawberries mitigate Alzheimer's risk? Recent study suggests a possibility

Perioperative immunotherapy improves event-free survival in resectable early-stage lung cancer

Dual-action drug produces shows promising results in neuroendocrine tumor trial

Everolimus after surgery may benefit patients with very-high-risk clear cell renal cell carcinoma

Clinical study evaluates safety and efficacy of methylone in patients with severe PTSD

Study finds more mature gut microbiome in malnourished Nigerien children after antibiotic treatment

Can selenium and vitamin E supplementation prevent recurrence and progression of non–muscle-invasive bladder cancer?

More antibiotics not better for preventing infection after joint replacement surgery, study finds

New treatment options offer hope for patients with non-small cell lung cancer

Late-breaking studies could change the treatment landscape for women with gynecological cancers

Oral diabetes and obesity meds danuglipron and orforglipron show promise but have gastrointestinal drawbacks

Tirzepatide boosts weight loss in lifestyle intervention patients, but comes with a catch

Can creatine and resistance training trim your body fat percentage?

Widely available prescription drug can improve IBS symptoms

Can herbal remedies, spices, and dietary fibers offer effective treatment options for children with irritable bowel syndrome (IBS)?

Two simple solutions could help prevent postpartum hemorrhage

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

Latest News