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Artificial intelligence helps identify new key-lock pairs against coronavirus

The human immune defense is based on the ability of white blood cells to accurately identify disease-causing pathogens and to initiate a defense reaction against them.

23 Apr 2021

Researchers develop a method of fabrication for biodegradable polymer microcapsules

An international team led by a Skoltech researcher has developed a method of fabrication for biodegradable polymer microcapsules, made more efficient by turning to an unusual source of inspiration - traditional Russian dumpling, or pelmeni, making.

23 Apr 2021

Drug-discovery collaboration finds potential new antimalarial drug candidates

Potential new antimalarial drug candidates are being developed through an extended drug-discovery collaboration between Australian medical research institute WEHI and Janssen Pharmaceutica NV. The collaboration was facilitated by Johnson & Johnson Innovation.

22 Apr 2021

Changing the treatment paradigm for ‘cold’ tumors

Not all cancerous tumors are created equal. Some tumors, known as "hot" tumors, show signs of inflammation, which means they are infiltrated with T cells working to fight the cancer. Those tumors are easier to treat, as immunotherapy drugs can then amp up the immune response.

22 Apr 2021

Experimental drug reverses key symptoms of Alzheimer's disease in mice

Researchers at Albert Einstein College of Medicine have designed an experimental drug that reversed key symptoms of Alzheimer's disease in mice.

22 Apr 2021

Research data may provide new treatment options for hormone-dependent breast cancer

Notch proteins are key regulators of growth and differentiation of both normal and cancer cells. Researchers in Turku, Finland, have now demonstrated that the activities of distinct Notch family members are modified differently by phosphorylation.

22 Apr 2021

Developing nanoparticles to detect and kill multi-resistant pathogens

Multi-resistant pathogens are a serious and increasing problem in today's medicine. Where antibiotics are ineffective, these bacteria can cause life-threatening infections.

22 Apr 2021

FDA approves immunotherapy for treating patients with dMMR endometrial cancer

Today, the U.S. Food and Drug Administration granted accelerated approval to Jemperli (dostarlimab) for treating patients with recurrent or advanced endometrial cancer that has progressed on or following prior treatment with a platinum-containing chemotherapy and whose cancers have a specific genetic feature known as dMMR (which contain abnormalities that affect the proper repair of DNA inside the cell), as determined by an FDA-approved test.

22 Apr 2021

Drugs can help prevent progression of cardiac hypertrophy in hemodialysis patients

Patients with chronic kidney dysfunction frequently develop thickening of the heart muscle, so-called left ventricular hypertrophy. This is particularly pronounced in patients who are in the late stage of renal dysfunction, that is to say those requiring renal replacement therapy such as hemodialysis.

22 Apr 2021

Mutations in estrogen receptor gene associated with worse outcomes after breast cancer treatment

A small proportion of women who receive anti-estrogen treatment after breast cancer surgery have worse outcomes. This is associated with mutations in the estrogen receptor gene, according to a study from Lund University now published in JNCI Cancer Spectrum.

22 Apr 2021

Pre-Clinical Vaccine Adjuvant and Therapeutics Manufacturing

Analytik reports how its Microfluidizer® processors are enabling researchers develop a range of therapeutic formulations including vaccine adjuvants, liposomes and lipid nanoparticles.

From Analytik Ltd 22 Apr 2021

Bath scientists receive £1.3 million grant to develop a portable spice-detection device

University of Bath scientists have been awarded a research grant of £1.3 million to develop a portable device to detect the street drug ‘spice’ on the spot. They expect the new technology to be ready for use in clinical settings, prisons and across police services within three years.

22 Apr 2021

National registry needs to be set up for capturing pharma industry payments to clinicians and patient support groups

A national registry to capture all pharma/medical device industry payments and other benefits made to all clinicians, healthcare organizations and patient support groups should be set up as a matter of urgency in the UK, insists an editorial in the Drug and Therapeutics Bulletin (dtb).

22 Apr 2021

Some COX inhibitors/NSAIDs increase COVID-19 severity

A startling new preprint research paper posted to the medRxiv server warns against the use of commonly used non-steroidal anti-inflammatory drugs (NSAIDs) belonging to the category of cyclooxygenase inhibitors (COX inhibitors) in patients with coronavirus disease 2019 (COVID-19).

22 Apr 2021

Stem cell therapy can repair brain damage and improve memory function in mice

A one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia, a new UCLA study finds.

21 Apr 2021

Collaborative research could expedite or eliminate the need to manually adjust bioproduction process

Much of common pharmaceutical development today is the product of laborious cycles of tweaking and optimization.

21 Apr 2021

Shifts in care due to COVID-19 pandemic likely to drive drug expenditures in 2021

The COVID-19 pandemic heavily influenced spending on prescription drugs in the U.S. in 2020, according to the ASHP's (American Society of Health-System Pharmacists) National Trends in Prescription Drug Expenditures and Projections for 2021.

21 Apr 2021

Study: Women at high risk of breast cancer face financial barriers to care

Women at high risk of breast cancer face cost-associated barriers to care even when they have health insurance, a new study has found.

21 Apr 2021

Animal study shows how chemical compound in Indian Long Pepper works against glioblastoma

Piperlongumine, a chemical compound found in the Indian Long Pepper plant (Piper longum), is known to kill cancerous cells in many tumor types, including brain tumors.

21 Apr 2021

New blood-based test detects lymph node metastasis in individuals with high-risk T1 colorectal cancer

Scientists at City of Hope, a world-renowned independent research and treatment center for cancer and diabetes, have developed a novel, noninvasive liquid biopsy test for detecting lymph node metastasis in individuals with high-risk T1 colorectal carcinoma.

21 Apr 2021

Drugs News and Research

Artificial intelligence helps identify new key-lock pairs against coronavirus

Researchers develop a method of fabrication for biodegradable polymer microcapsules

Drug-discovery collaboration finds potential new antimalarial drug candidates

Changing the treatment paradigm for ‘cold’ tumors

Experimental drug reverses key symptoms of Alzheimer's disease in mice

Research data may provide new treatment options for hormone-dependent breast cancer

Developing nanoparticles to detect and kill multi-resistant pathogens

FDA approves immunotherapy for treating patients with dMMR endometrial cancer

Drugs can help prevent progression of cardiac hypertrophy in hemodialysis patients

Mutations in estrogen receptor gene associated with worse outcomes after breast cancer treatment

Pre-Clinical Vaccine Adjuvant and Therapeutics Manufacturing

Bath scientists receive £1.3 million grant to develop a portable spice-detection device

National registry needs to be set up for capturing pharma industry payments to clinicians and patient support groups

Some COX inhibitors/NSAIDs increase COVID-19 severity

Stem cell therapy can repair brain damage and improve memory function in mice

Collaborative research could expedite or eliminate the need to manually adjust bioproduction process

Shifts in care due to COVID-19 pandemic likely to drive drug expenditures in 2021

Study: Women at high risk of breast cancer face financial barriers to care

Animal study shows how chemical compound in Indian Long Pepper works against glioblastoma

New blood-based test detects lymph node metastasis in individuals with high-risk T1 colorectal cancer

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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