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Engineered allosteric regulation provides precise control of kinase activity in living cells

Cancer occurs when human cells move and multiply inappropriately. Within cells, a process called phosphorylation serves as an on/off switch for a number of cellular processes that can be involved in cancer, including metabolism, transcription, configuration, movement, cell death and differentiation. This process is controlled by a group of enzymes called protein kinases that - working together and separately - modify the structure of proteins, changing them and allowing them to control cellular processes.

28 Jun 2010

Halozyme presents new data from Ultrafast Insulin development program at 70th ADA

Halozyme Therapeutics, Inc. today announced Phase 2 results demonstrating that the subcutaneous coinjection of rHuPH20 (recombinant human hyaluronidase, PH20) with lispro significantly improves postprandial hyperglycemia, reduces hypoglycemia, and accelerates the absorption of mealtime insulin in patients with type 2 diabetes.

28 Jun 2010

VPRIV receives positive opinion from CHMP for treatment of type 1 Gaucher disease

Shire plc, the global specialty biopharmaceutical company, announced today that the Committee for Medicinal Products for Human Use of the European Medicines Agency adopted a positive opinion on the marketing authorisation for VPRIV (velaglucerase alfa), the company's enzyme replacement therapy for the treatment of type 1 Gaucher disease.

28 Jun 2010

New findings could lead to simple dietary solutions, possible therapeutics for gestational diabetes

The cause of diabetes during pregnancy is directly controlled by serotonin, a chemical produced by the body and normally known as a neurotransmitter, and is influenced by the amount of protein in the mother's diet early in pregnancy, according to new findings of an international team led by researchers at UCSF.

28 Jun 2010

Researchers identify a key player in dramatic loss of neurons in mice and fly models

A team of researchers, led by scientists at the University of California, San Diego, have identified a key player in the dramatic loss of neurons in mice and fly models, a discovery that could help illuminate the role of mitochondrial dysfunction in human neurodegenerative disorders, such as Parkinson's disease.

25 Jun 2010

Scientists report first preliminary description of bed bug's sialome

With bed bugs reemerging as a nuisance in some parts of the country, scientists are reporting the first preliminary description of the bug's sialome - the saliva proteins that are the secret to Cimex lectularius' ability to suck blood from its human victims and escape to bite again with risking a lethal slap. The findings, which could have medical applications in diagnosing bed bug bites and preventing the itch, appear in ACS' monthly Journal of Proteome Research.

25 Jun 2010

Two experimental drugs have potential to restore pumping strength to failing hearts, study finds

We've all experienced the strong heartbeat that accompanies emotions such as fear and rage. But can the body's natural response to these emotions be used to combat heart failure? Results of a study published online today in the journal Circulation Research present a strong case.

25 Jun 2010

Abbott's new FreeStyle test strips receive FDA clearance

Following the recent clearance of its FreeStyle Lite® blood glucose test strips, Abbott (NYSE: ABT) today announced that it has also received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its new FreeStyle blood glucose test strips.

25 Jun 2010

UNC team provides first example of successful radiomitigation in mammals

While radiation has therapeutic uses, too much radiation is damaging to cells. The most important acute side effect of radiation poisoning is damage to the bone marrow. The bone marrow produces all the normal blood cells, and therefore a high dose of radiation can lead to low blood counts of red cells, platelets and white blood cells.

24 Jun 2010

People with certain chitinase gene variants at increased risk of severe asthma attacks

Exposure to high levels of fungus may increase the risk of severe asthma attacks among people with certain chitinase gene variants, according to a study from Harvard Medical School, Harvard Pilgrim Health Care Institute and Brigham and Women's Hospital.

24 Jun 2010

Researchers find why patients with XPV are more susceptible to skin cancer

Researchers from Mount Sinai School of Medicine have found why patients with a variant form of xeroderma pigmentosum, an inherited genetic disorder characterized by extreme sensitivity to the sun, are more susceptible to skin cancers than the general population. The data are published in the current issue of the journal Nature. Their finding sets the stage for research into therapies that would help protect people with XPV from developing skin cancers.

24 Jun 2010

Health Diagnostic Laboratory announces new capability to run CYP2C19 genetic test

Health Diagnostic Laboratory, Inc., a leader in disease state management, today announced its new capability to run the CYP2C19 genetic test. HDL, Inc., headquartered in the Virginia Biotechnology Research Park, has added CYP2C19 to its comprehensive panel of tests to help physicians better personalize treatment based on an expanded, total patient profile.

24 Jun 2010

EUCODIS Bioscience launches high-performance beta-lactamase

EUCODIS Bioscience, a developer and manufacturer of customized enzymes today announced that it has launched a high-performance beta-lactamase designed to inactivate a broad range of beta-lactam antibiotics. EUCODIS Bioscience is marketing the product under the LacBuster(TM) brand.

23 Jun 2010

K-State chemical engineer patents chemical structure to make natural personal care products in lab

A Kansas State University chemical engineer has developed and patented a chemical structure to make all-natural personal care products and purer pharmaceuticals in the laboratory.

23 Jun 2010

Student receives two-year $46,000 fellowship to research on a parasite that causes Chagas' disease

Michelle Oppenheimer of Charlotte, N.C., a Ph.D. student in biochemistry in the College of Agriculture and Life Sciences at Virginia Tech, has received a two-year $46,000 fellowship from the American Heart Association to advance her research on a parasite that causes Chagas' disease, which can lead to swelling and inflammation of the heart.

23 Jun 2010

Scientists discover weakness of human louse

Scientists have discovered the human louse's Achilles' heel which could lead to new treatments to rid us of body and head lice infestations.

23 Jun 2010

Phase I/II clinical trials show crizotinib reduces lung cancer tumors

Patients with a specific kind of lung cancer may benefit from a Phase III clinical trial offered by the Moores UCSD Cancer Center. The new drug, crizotinib, under development by Pfizer, showed dramatic results in reducing lung cancer tumors in some patients during Phase I and II clinical trials.

23 Jun 2010

Fructose makes cells mature into fat cells in belly fat, study finds

Fructose, the sugar widely used as high-fructose corn syrup in soft drinks and processed foods, often gets some of the blame for the widespread rise in obesity. Now a laboratory study has found that when fructose is present as children's fat cells mature, it makes more of these cells mature into fat cells in belly fat and less able to respond to insulin in both belly fat and fat located below the skin.

22 Jun 2010

International team obtains genome sequence of human body louse

An international team has obtained the genome sequence of the human body louse (Pediculus humanus humanus), a parasite that feeds on the blood of its host and a vector of pathogens that cause diseases such as epidemic typhus, relapsing fever and trench fever.

22 Jun 2010

Beneficial effects of LifeVantage's Protandim on DMD mouse model published in Journal of Dietary Supplements

LifeVantage Corporation, the maker of Protandim®, a patented, science-based solution to oxidative stress, announced today that a peer-reviewed manuscript was published in the Journal of Dietary Supplements examining the beneficial effects of Protandim® on a mouse model of Duchenne Muscular Dystrophy (DMD), an X-linked inherited disease affecting one in 3,500 males.

22 Jun 2010

Enzyme News and Research

Engineered allosteric regulation provides precise control of kinase activity in living cells

Halozyme presents new data from Ultrafast Insulin development program at 70th ADA

VPRIV receives positive opinion from CHMP for treatment of type 1 Gaucher disease

New findings could lead to simple dietary solutions, possible therapeutics for gestational diabetes

Researchers identify a key player in dramatic loss of neurons in mice and fly models

Scientists report first preliminary description of bed bug's sialome

Two experimental drugs have potential to restore pumping strength to failing hearts, study finds

Abbott's new FreeStyle test strips receive FDA clearance

UNC team provides first example of successful radiomitigation in mammals

People with certain chitinase gene variants at increased risk of severe asthma attacks

Researchers find why patients with XPV are more susceptible to skin cancer

Health Diagnostic Laboratory announces new capability to run CYP2C19 genetic test

EUCODIS Bioscience launches high-performance beta-lactamase

K-State chemical engineer patents chemical structure to make natural personal care products in lab

Student receives two-year $46,000 fellowship to research on a parasite that causes Chagas' disease

Scientists discover weakness of human louse

Phase I/II clinical trials show crizotinib reduces lung cancer tumors

Fructose makes cells mature into fat cells in belly fat, study finds

International team obtains genome sequence of human body louse

Beneficial effects of LifeVantage's Protandim on DMD mouse model published in Journal of Dietary Supplements

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