Acute Lymphoblastic Leukemia News and Research

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Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells, the cells in the body that normally fight infections. There are two main types of white blood cells-lymphoid cells and myeloid cells. ALL affects lymphoid cells.

GOSH delivers world-first base-edited cell therapy for a patient with relapsed T cell leukemia

A patient with relapsed T cell leukemia has been given base-edited T-cells in a world-first use of a base-edited cell therapy, in a 'bench-to-bedside' collaboration between UCL and Great Ormond Street Hospital for Children (GOSH).

12 Dec 2022

Extra year of chemotherapy lowers the risk of cancer recurrence in children with Ikaros leukemia

Many children with ALL have a good outcome of their disease. After two years of chemotherapy treatment, nine out of ten children are cured. But some children have a more aggressive form of the disease.

12 Dec 2022

Study finds no differences in CAR T-cell therapy outcomes among pediatric ALL patients across different socioeconomic levels

Social determinants of health affect the outcomes of many illnesses, and pediatric cancer is no exception. In fact, children with acute lymphoblastic leukemia (ALL) living in poverty are significantly more likely to relapse and die from their disease than those from wealthier backgrounds.

11 Nov 2022

Exploring biological mechanisms behind the link between obesity prior to pregnancy and elevated risk of pediatric ALL

Published in Leukemia Research, University of Minnesota Medical School researchers explored the possible biological mechanisms that could explain the association between being overweight or obese prior to pregnancy and the increased risk of acute lymphoblastic leukemia (ALL) in children.

28 Sep 2022

Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Up to three quarters of patients receiving cancer chemotherapy suffer from "chemo brain" - a long-term side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, whose brains are still developing, their schoolwork and self-esteem may suffer.

13 Sep 2022

St. Baldrick's Scholar grant awarded to CU researcher for investigating new drug to treat infant leukemia

As part of its ongoing efforts to eradicate childhood cancers, the St. Baldrick's Foundation has awarded University of Colorado Cancer Center member Kelly Faulk, MD, a St. Baldrick's Scholar grant to investigate a new method for treating infant leukemia.

9 Sep 2022

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

Scientists have created a roadmap of the genetic mutations present in the most common childhood cancer, acute lymphoblastic leukemia (ALL).

1 Sep 2022

Unconventional oil and gas development exposure increases the risk for acute lymphoblastic leukemia in children

A new study assessed the associations between residential proximity to unconventional oil and gas development and acute lymphoblastic leukemia risk.

23 Aug 2022

For medically vulnerable families, inflation’s squeeze is inescapable

Deborah Lewis rose from bed before dawn and signed in to her phone so she could begin delivering fast food, coffee, and groceries to residents in this western patch of the Mojave Desert where test pilot Chuck Yeager broke the sound barrier generations ago.

15 Aug 2022

Higher doses of CAR-T therapy achieve better survival rates for young patients with hard-to-treat B-ALL

Young people who received doses of tisagenlecleucel, a chimeric antigen receptor T cell (CAR-T) therapy, at the higher end of the FDA-approved dosing range had significantly better survival rates at one year compared with those who received lower doses within this range, according to research published today in Blood Advances.

8 Aug 2022

Epigenetic changes prevent iron-associated programmed cell death in leukemia, research shows

The article, published in the journal Redox Biology by the group of Dr. Manel Esteller, shows that epigenetic changes prevent iron-associated programmed cell death in leukemia and show a new target for treatment with experimental drugs.

1 Aug 2022

NCCN publishes new guidelines for treating pediatric CNS cancers

Today, the National Comprehensive Cancer Network published new NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Pediatric Central Nervous System Cancers.

12 Jul 2022

Rare Cells Capable of Transforming into Leukemia may Provide new Insight into Leukemic Landscape

In our latest interview, News Medical speaks to Adam G. Schrum, PhD, Associate Professor of Molecular Microbiology & Immunology and Surgery at the University of Missouri, about how dysfunction in an unusual type of thymocyte cell may develop into leukemia in some patients.

8 Jul 2022

Study identifies chromosomal abnormalities associated with relapse in frequent subtype of childhood B-ALL

An international research team coordinated by Dr. Oscar Molina and Dr. Pablo Menéndez, from the Josep Carreras Leukaemia Research Institute, identifies chromosomal abnormalities associated to relapse in a frequent subset of B-cell Acute Lymphoblastic Leukemia (B-ALL), a severe condition affecting especially children.

7 Jul 2022

Unusual type of thymocyte cells capable of transforming into blood cancer discovered

Dysfunction involving an unusual type of thymocyte cell found in small amounts in every person may be the reason why some people develop a form of leukemia called T-cell acute lymphoblastic leukemia (T-ALL) that affects more than 6,000 Americans each year.

28 Jun 2022

New combination of drugs effective against T-cell acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is the most common cancer affecting children. The T-ALL form of leukemia that emerges from early T lineage cells has a poorer prognosis than B-lineage ALL. The prognosis for relapsed T-ALL is very poor and new therapies are sorely needed.

20 Jun 2022

Research reveals how highly proliferative leukemia cells turn into normal harmless ones

A new research describes how highly proliferative leukemia cells end up becoming normal cells that no longer multiply, by changing the chemical modifications -the so-called epigenetics- of a type of its genetic material: the messenger RNA.

9 Jun 2022

New research may open a window to treating aggressive form of B-cell acute lymphoblastic leukemia

Survival has improved greatly in children with acute lymphocytic leukemia (ALL). But a certain form of ALL that occurs mostly in babies is still very lethal, with a survival rate below 50 percent: B-cell acute lymphoblastic leukemia with rearrangements of the mixed lineage leukemia gene, or MLL B-ALL.

1 Jun 2022

Adolescent and young adult leukemia survivors have reduced long-term survival compared to peers without cancer

Researchers at The University of Texas MD Anderson Cancer Center have discovered that adolescent and young adult (AYA) cancer survivors of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) have reduced long-term survival rates compared to their peers without cancer.

13 May 2022

New classification by ESMO to guide research on treatment de-escalation in oncology

ESMO, the leading professional organization for medical oncology, has developed a new evidence-based classification to guide research and interpretation of data on treatment de-escalation in oncology.

11 May 2022