Glycosylation News and Research

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Study indicates widespread SARS-CoV-2 exposure in wildlife

In a recent study posed to the bioRxiv* preprint server, researchers at Virginia Tech University investigated wildlife exposure to SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).

8 Nov 2022

The Native Antigen Company expands its range of Omicron antigens to include BA.5 variant

The Native Antigen Company (part of LGC Clinical Diagnostics), one of the world’s leading suppliers of reagents that enables research into vaccines and diagnostics for emerging and endemic infectious diseases, today announced the commercial launch of its latest SARS-CoV-2 antigens for the newly designated Omicron BA.5 variant.

From The Native Antigen Company 7 Nov 2022

Study reviews hydroxychloroquine and remdesivir antiviral potency against SARS‐CoV‐2

In a new study, researchers outlined the synthesis and the possible mechanism of action (MOA) of two potential severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) repurposing drug candidates.

17 Oct 2022

Vaccine-induced neutralizing and non-neutralizing antibody activity against SARS-CoV-2

A new study demonstrated that vaccine-induced antibody functions against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diminish with age.

7 Oct 2022

Effectiveness of anti-SARS-CoV-2 immunoadhesin against omicron and other emerging variants

A new study demonstrated the efficacy of a newly engineered angiotensin-converting enzyme 2 (ACE2) based immunoadhesin against Omicron and other SARS-CoV-2 VOCs.

30 Sep 2022

What is the role of N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 spike maturation?

A new study showed that SARS-CoV-2 Spike N-glycosylation patterns, intracellular lectins, and the associated molecular chaperones play crucial roles in the viral-host-cell invasion and function.

28 Sep 2022

New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

Researchers described a novel antiviral mechanism of action for an FDA (food and drug administration)-approved thiopurine known as 6-thioguanine (6-TG).

21 Sep 2022

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

In a recent study posted to the bioRxiv* preprint server, researchers from Spain, the United Kingdom, and the United States used chemical tools to uncover the molecular details of glycan-mediated modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) processing.

19 Sep 2022

What is the impact of COVID-19 treatments targeting intracellular Neu1?

In a new study, researchers assessed the impact of targeting intracellular Neu1 on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

14 Sep 2022

Exploration of glycan shield structure of sarbecoviruses provides new insights into developing pan-coronavirus vaccines

A new study explored the glycan shield diversity of sarbecoviruses, furthering the knowledge for developing broad-range pan-coronavirus vaccines.

30 Aug 2022

How natural alterations inside the SARS-CoV-2 glycan barrier affect spike protein dynamics

Researchers explored how the natural alterations inside the SARS-CoV-2 glycan barrier affect the spike protein dynamics.

22 Aug 2022

How do BNT162b2 vaccine-induced neutralizing and non-neutralizing antibodies synergize to promote protection against SARS-CoV-2?

Scientists explored the COVID-19 BNT162b2 vaccine triggered non-neutralizing and neutralizing antibody functions.

18 Aug 2022

A broad sarbecovirus-neutralizing antibody cocktail

Researchers present a rational approach for identifying SARS-CoV-2 receptor-binding domain-targeted broad neutralizing antibody cocktails.

9 Aug 2022

Study identifies broad-spectrum antibody that neutralizes SARS-CoV-2 variants of concern

Scientists have described the identification and therapeutic evaluation of an antibody that broadly neutralizes major variants of SARS-CoV-2, including the alpha, beta, delta, and omicron variants.

5 Aug 2022

Researchers investigate the feasibility of modifying cholera toxin for targeted delivery to specific organelles

Proteins usually undergo modifications during or after their synthesis in the endoplasmic reticulum (ER) and Golgi apparatus network inside eukaryotic cells.

25 Jul 2022

Parents become drug developers to save their children’s lives

Maggie Carmichael wasn't developing like other kids. As a toddler, she wasn't walking and had a limited vocabulary for her age.

21 Jul 2022

Nitazoxanide drug found to be a potent inhibitor of several human coronaviruses

Researchers evaluated the activity of nitazoxanide against human coronaviruses (HCoVs).

18 Jul 2022

Study results encourage SARS-CoV-2–infected mothers breastfeed to protect infants from COVID

A new study examines the strength of protection against COVID-19 using antibody concentrations at birth and after six months in mothers and children.

17 Jul 2022

New regulatory code of protein glycosylation

Many proteins in nature exist as glycoproteins, which consist of protein (polypeptide chain) and glycan (sugar chain).

13 Jul 2022

Stinging nettle extract inhibits SARS-CoV-2 cell fusion

In a recent study posted to the bioRxiv* preprint server, researchers at Ghent University and KU Leuven, Belgium, demonstrated that Urtica dioica agglutinin (UDA), a monomeric lectin extracted from stinging nettle rhizomes, inhibited severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) cell to cell fusion.

12 Jul 2022