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New findings could make off-the-shelf CAR T cell therapy a reality

CAR T cell therapy is one of the most promising new cancer treatments to emerge in recent years. It involves removing a patient's own immune T cells and engineering them to recognize specific targets on the surface of the cancer cell.

31 Jan 2025

Inherited gene mutation found to increase prostate cancer risk

A study of men with a family history of prostate cancer has discovered an inherited form of prostate cancer.

28 Jan 2025

What causes behavioral side effects in popular weight loss drugs?

The study of GLP1R variants shows associations with cardiometabolic traits and behavioral changes, highlighting indirect effects of GLP1RA on mental health.

23 Jan 2025

GLP1RA medications linked to behavioral side effects in type 2 diabetes and obesity

Glucagon-like peptide 1 receptor agonists (GLP1RA)-medications for type 2 diabetes and obesity that have recently been making headlines due to a rise in popularity as weight loss agents-have been linked with behavioral side effects.

22 Jan 2025

Study identifies novel IgAN loci through pleiotropy

IgA nephropathy (IgAN) is a prevalent form of primary glomerulonephritis characterized by the deposition of IgA in the glomerular mesangium, leading to a spectrum of histopathological lesions and a variable clinical course that can progress to end-stage renal disease in a significant proportion of patients.

2 Jan 2025

Study uncovers a previously unknown genetic link to autism spectrum disorder

New research published in The American Journal of Human Genetics has identified a previously unknown genetic link to autism spectrum disorder (ASD). The study found that variants in the DDX53 gene contribute to ASD, providing new insights into the genetic underpinnings of the condition.

19 Dec 2024

Neanderthal legacy: The surprising genetics behind human tooth size

A recent study identifies key genetic factors—PITX2 expression and Neanderthal-introgressed HS3ST3A1—that contribute to variations in tooth size among modern human populations, especially highlighting differences across ancestries.

17 Dec 2024

Nutrient metabolism regulates T cell exhaustion and therapy potential

Findings reveal that metabolic enzymes ACSS2 and ACLY regulate T cell exhaustion, linking nutrient metabolism to epigenetic changes in immunity.

17 Dec 2024

SRF awards $230,000 grant to advance research on SYNGAP1-Related Disorders

The SynGAP Research Fund (SRF) has awarded a $230,000 grant to The Jackson Laboratory Rare Disease Translational Center to characterize a mouse model for SYNGAP1-Related Disorders, (SRD), a severe neurodevelopmental disorder marked by seizures, intellectual disabilities, and motor and behavioral challenges.

4 Dec 2024

Polypurine hairpins found to effectively halt SARS-CoV-2 replication

A study led by the University of Barcelona and the Spanish National Research Council's Institute for Advanced Chemistry of Catalonia (IQAC - CSIC) presents a new therapeutic tool capable of inhibiting the proliferation of the SARS-CoV-2 virus that causes COVID-19.

3 Dec 2024

Scientists identify drug-resistant bone marrow cells linked to poor outcomes in fast-growing leukemia

Researchers explore treatment resistance and relapse in T-cell acute lymphoblastic leukemia.

29 Nov 2024

Depression increases chances of experiencing menstrual pain

Scientists investigate the genetic relationship between depression and dysmenorrhea.

27 Nov 2024

Research identifies the brain's 'locus coeruleus' as key player in sleep cycles

Researchers at the University of Lausanne have identified a novel role for the brain's 'locus coeruleus' in sleep and its disruptions.

25 Nov 2024

New data highlights spread of carbapenem-resistant infections in Europe

Patients seeking treatment in hospital or other healthcare facilities can be particularly vulnerable for infections they acquire during their stay, especially if the infections are difficult to treat because they are resistant to commonly used drugs.

22 Nov 2024

Scientists uncover cerebrospinal fluid markers for Alzheimer's detection and treatment

Researchers map the unique genetic regulation of proteins in human cerebrospinal fluid, identifying potential targets for Alzheimer’s treatments.

12 Nov 2024

Revolutionary AI predicts aging and disease from DNA patterns

Researchers developed CpGPT, a novel foundation model for DNA methylation analysis that captures sequence, positional, and epigenetic context to predict aging and disease risks. This model offers breakthroughs in imputing missing data and improving mortality and morbidity predictions.

11 Nov 2024

New insights into the genetic legacy of Denisovans

Scientists believe individuals of the most recently discovered "hominin" group (the Denisovans) that interbred with modern day humans passed on some of their genes via multiple, distinct interbreeding events that helped shape early human history.

8 Nov 2024

New insights on the association between genes, gut microbiota, and mental health

The study identifies links between gut microbiota, genetic variants in IBD, and mental health disorders, offering insights into potential biomarkers for CMDs.

31 Oct 2024

Impact of TLR10 rs10004195 genotype on susceptibility to H. pylori infection

Helicobacter pylori (H. pylori) infection can cause multiple secondary digestive disorders. Some studies have found that polymorphisms in Toll-like receptor (TLR) genes, including TLR10 rs10004195, may be associated with increased susceptibility to H. pylori infection. Despite conflicting reports, we conducted a meta-analysis to clarify the relationship between these factors.

26 Oct 2024

Study connects brain volume variations with genetic risk factors for Parkinson’s disease and ADHD

Unprecedented genome analysis reveals genetic links between brain structure and disorders like Parkinson's and ADHD, paving the way for innovative treatments.

23 Oct 2024