Malignant News and Research

RSS

New method creates longer lasting CAR T cells for cancer therapy

A research team led by Albert Einstein College of Medicine scientists has developed a new strategy to engineer immune cells that dramatically prolongs their effectiveness after being infused into patients to fight cancer and HIV, addressing a major limitation of current treatments.

13 Mar 2026

Combined CDK4/6 and EGFR inhibition improves pancreatic cancer therapy

Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare.

13 Mar 2026

New AI system reduces pathologist workload while maintaining diagnostic accuracy

Artificial intelligence could make cancer diagnosis safer and fairer by learning when to defer to human pathologists without overloading them, according to researchers from the University of Surrey and Monash University.

13 Mar 2026

Experimental therapy eliminates pancreatic precancerous cells in mice study

A new preclinical study in mice shows that precancerous cells in the pancreas can be eliminated before they have the chance to become tumors.

12 Mar 2026

Boron neutron capture therapy shows promise for deadly brain tumors

Malignant gliomas are among the deadliest brain cancers, with limited treatment options and poor survival.

9 Mar 2026

How somatic mutations shape disease and reveal new drug targets

Researchers reviewed how somatic mutations accumulate in normal and diseased tissues, showing that natural selection can expand clones that influence disease risk, tissue adaptation, or cellular resilience. The study proposes somatic genomics as a powerful strategy to uncover disease mechanisms and identify new therapeutic targets across multiple conditions.

8 Mar 2026

Restoring cellular vibration reduces aggressiveness of advanced vocal cord cancer

The continuous movement of the vocal cords weakens and eventually stops as laryngeal cancer progresses.

4 Mar 2026

Study reveals cellular and metabolic landscape of lymph node metastasis in breast cancer

A recent integrative analysis of single-cell sequencing and single-cell spatial mapping of lymph node metastasis in breast cancer reveals novel mechanisms of the metabolic-immune interaction that drive the spread of breast cancer.

2 Mar 2026

Common cardio drugs proven safe in myeloma patients

Commonly prescribed cardiovascular medications—such as statins, diuretics, and blood pressure drugs—appear to have little or no negative impact on survival among people living with multiple myeloma, according to new international research.

1 Mar 2026

Jumping DNA fragments found to destabilize cancer genome

A study published today in the journal Science reveals how jumping fragments of human DNA, a type of genetic parasite, destabilise the cancer genome. Unstable genomes are a fertile playground for cancer evolution, giving malignant cells more opportunities to grow, adapt and evade treatment.

26 Feb 2026

Targeting glutamine metabolism offers new hope for synovial sarcoma treatment

Synovial sarcoma is an aggressive malignant tumor that primarily affects the limbs of teenagers and young adults.

26 Feb 2026

Phase 2 clinical trial tests LMP744 for the treatment of first-time recurrent glioblastoma

Gibson Oncology, a clinical-stage private pharmaceutical company headquartered in Miami, announced it has entered Phase 2 clinical trials with LMP744 for the treatment of first-time recurrent glioblastoma patients.

25 Feb 2026

New insights on spontaneous coronary artery dissection in young patients

New insights into spontaneous coronary artery dissection – a devastating cause of heart attacks in young, healthy patients – were presented today at the EAPCI Summit 2026.

20 Feb 2026

Low-field MRI could offer an alternative to existing breast cancer screening methods

Mass General Brigham's evaluation of low-field MRI performance lays potential groundwork for this technology to be a lower-cost, accessible option for breast imaging.

19 Feb 2026

Polyploidy-induced senescence may influence aging and cancer risk

A new editorial was published in Volume 18 of Aging-US on February 8, 2026, titled "Polyploidy-induced senescence: Linking development, differentiation, repair, and (possibly) cancer?"

18 Feb 2026

Frailty impacts heart attack survival differently by sex

Pioneering research from the University of Leicester and NIHR challenges the 'one-size-fits-all' approach to heart attack care, adding critical nuance to the debate on sex disparities.

18 Feb 2026

Changes in lymphatic vessels can help identify aggressive oral cancer at an early stage

Oral cancers are the most common malignant tumors in the head and neck region, causing more than 188,000 deaths worldwide each year.

18 Feb 2026

Researchers find new way to halt leukemia stem cell growth

In a new study published in Nature Communications, a research team at the University of Oslo have examined how cancer cells develop in the bone marrow and whether it might be possible to stop them.

18 Feb 2026

CNN-based system improves lung nodule detection and classification

Lung cancer remains the leading cause of cancer-related mortality worldwide. Early detection of pulmonary nodules is crucial for timely diagnosis and effective treatment.

16 Feb 2026

Novel neuroprotective drug improves recovery after acute ischemic stroke

Stroke patients treated intravenously with loberamisal, a novel neuroprotective medication, daily for 10 days and starting within 48 hours of stroke symptoms, had better recovery than patients who received a placebo, according to a preliminary late-breaking science presentation at the American Stroke Association's International Stroke Conference 2026.

7 Feb 2026