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Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Replacing APOE4 with APOE2 in adult mice rapidly reshapes brain lipids and gene expression, even after development is complete. This switch, especially when targeted to astrocytes, reduces amyloid burden, dampens gliosis, and improves associative memory despite E2-like peripheral lipid risks.

12 Nov 2025

Utah researchers uncover microglia as key regulators of anxiety in the brain

Anxiety disorders are some of the most common mental health conditions in America, affecting about one in five people nationwide.

11 Nov 2025

Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections

Lowering the transcription factor PU.1 reprograms microglia into a neuroprotective, lymphoid-like state that compacts amyloid, blocks tau spread, and preserves synapses in Alzheimer’s disease. Microglial CD28 signaling helps restrain inflammation, revealing a regulatory switch that may inform future immunotherapies targeting microglia rather than neurons.

6 Nov 2025

Newly identified microglia subtype offers protection against Alzheimer’s disease

In Alzheimer's disease, the leading cause of dementia, microglia-the brain's immune defenders-can act as both protectors and aggressors, shaping how the disease progresses.

5 Nov 2025

GLP-1 drugs calm inflammation beyond diabetes and weight loss

This Journal of Clinical Investigation review describes how glucagon-like peptide-1 (GLP-1)–based medicines reduce systemic and tissue inflammation through both weight-dependent and weight-independent mechanisms. It details preclinical and clinical evidence linking GLP-1 receptor activation to cardiovascular, renal, hepatic, neural, and joint anti-inflammatory effects while outlining uncertainties and future research needs.

4 Nov 2025

Scientists uncover excessive maturation and aging in the hippocampus

In a groundbreaking study, researchers at Fujita Health University and the Tokyo Metropolitan Institute of Medical Science have uncovered a previously overlooked form of brain abnormality linked to anxiety: excessive maturation and aging in the hippocampus, a state they term "hyper-maturity."

27 Oct 2025

New discovery reshapes understanding of how brain inflammation arises in Alzheimer's disease

Researchers at the University of California, Irvine, have uncovered an unexpected molecular partnership that reshapes scientists' understanding of how brain inflammation arises in Alzheimer's disease.

23 Oct 2025

Disruption of glial circadian rhythms linked to Alzheimer's disease progression

Alzheimer's disease is notorious for scrambling patients' daily rhythms. Restless nights with little sleep and increased napping during the day are early indicators of disease onset, while sundowning, or confusion later in the day, is typical for later stages of the disease.

23 Oct 2025

Study reveals how a microglial mutation increases risk for Alzheimer's disease

Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper published in Neuron, "The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer's Disease by Impairing Microglial Function."

17 Oct 2025

New 3D human brain tissue platform integrates all major brain cell types into a single culture

A new 3D human brain tissue platform developed by MIT researchers is the first to integrate all major brain cell types, including neurons, glial cells and the vasculature into a single culture.

17 Oct 2025

Discovery explains why women face higher risk of Alzheimer’s and multiple sclerosis

New research by UCLA Health has identified a sex-chromosome linked gene that drives inflammation in the female brain, offering insight into why women are disproportionately affected by conditions such as Alzheimer's disease and multiple sclerosis as well as offering a potential target for intervention.

15 Oct 2025

Researchers develop AI system to decode the human immune system

Researchers explore the human immune system by looking at the active components, namely the various genes and cells involved.

9 Oct 2025

State-of-the-art microchips help understand how sepsis and neurodegenerative diseases damage the brain

In lieu of animal experiments, researchers from the University of Rochester are using state-of-the-art microchips with human tissue to better understand how the brain operates under healthy conditions and is damaged through neurodegenerative diseases or conditions like sepsis.

7 Oct 2025

Live retinal imaging uncovers early signs of diabetic eye disease

A new method of taking microscopic images of a live mouse's retina through the eye allows to record the reaction of brain cells to disease and treatment.

6 Oct 2025

Study links high neuroinflammation in young people with Down Syndrome to Alzheimer's risk

Down syndrome is associated with accelerated aging. It is estimated that up to 90% of individuals with the condition develop Alzheimer's disease before the age of 70. A study by researchers at the University of São Paulo (USP) in Brazil identified high levels of neuroinflammation in young individuals with Down syndrome, an additional factor explaining the high prevalence of Alzheimer's disease in older people with the condition. The discovery paves the way for strategies to prevent and monitor the disease.

3 Oct 2025

Natural psychoactive molecule DMT reduces harmful effects of stroke in animal models

DMT, or dimethyltryptamine is a natural psychoactive molecule found in many plants and mammals. According to an article published in Science Advances, researchers from the HUN-REN BRC Institute of Biophysics and Semmelweis University Heart and Vascular Centre found that DMT reduces the harmful effects of stroke in animal models and cell culture experiments.

26 Sep 2025

Mount Sinai study maps protein networks driving Alzheimer’s disease pathogenesis

A new study led by the Icahn School of Medicine at Mount Sinai offers one of the most comprehensive views yet of how brain cells interact in Alzheimer's disease, mapping protein networks that reveal communication failures and point to new therapeutic opportunities.

25 Sep 2025

Microglia News and Research

Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Utah researchers uncover microglia as key regulators of anxiety in the brain

Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections

Newly identified microglia subtype offers protection against Alzheimer’s disease

GLP-1 drugs calm inflammation beyond diabetes and weight loss

Scientists uncover excessive maturation and aging in the hippocampus

New discovery reshapes understanding of how brain inflammation arises in Alzheimer's disease

Disruption of glial circadian rhythms linked to Alzheimer's disease progression

Study reveals how a microglial mutation increases risk for Alzheimer's disease

New 3D human brain tissue platform integrates all major brain cell types into a single culture

Discovery explains why women face higher risk of Alzheimer’s and multiple sclerosis

Researchers develop AI system to decode the human immune system

State-of-the-art microchips help understand how sepsis and neurodegenerative diseases damage the brain

Live retinal imaging uncovers early signs of diabetic eye disease

Study links high neuroinflammation in young people with Down Syndrome to Alzheimer's risk

Natural psychoactive molecule DMT reduces harmful effects of stroke in animal models

Mount Sinai study maps protein networks driving Alzheimer’s disease pathogenesis

Advanced imaging exposes breakdown in brain cell communication linked to Alzheimer’s

Repetitive head impacts trigger early brain changes in young athletes

How processed red meat might drive neurodegenerative diseases

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

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How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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