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Australian rainforest remedies: Scientists explore bioactive plant compounds as potential anti-neuroinflammatory agents

Research discusses the process of discovering anti-inflammatory and neuroprotective drugs from medicinal plants found in the Australian rainforest. It focuses on the pathways from the discovery of bioactive plants to the validation in an appropriate neuro-inflammatory mouse model, using some examples from their current research.

9 Jul 2023

How does space affect the immune system of astronauts?

Research explores the effects of microgravity and radiation on the immune system in space conditions. It emphasizes the need to understand these effects for future long-duration space missions and highlights knowledge gaps for further investigation.

2 Jul 2023

New research shows antibody cross-reactivity between human and animal coronaviruses

Researchers probed for antibody binding against all seven human coronaviruses (hCoVs).

27 Jun 2023

Manipulating white blood cells to eliminate solid tumors

By silencing the molecular pathway that prevents macrophages from attacking our own cells, Penn Engineers have manipulated these white blood cells to eliminate solid tumors.

12 Jun 2023

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

MFAP5, a microfibril-associated protein, plays a significant role in wound healing by regulating fibroblast function, collagen deposition, and angiogenesis, suggesting its potential as a modulator of scar formation.

1 Jun 2023

Case study: Experimental lecanemab treatment causes adverse outcomes in 65-year-old woman with Alzheimer's disease

In a noteworthy case study published in the Journal of Alzheimer's Disease investigators report autopsy findings in a 65-year-old woman with Alzheimer's disease (AD) who received three open label infusions of the experimental anti-amyloid beta (Aβ) antibody drug lecanemab.

25 May 2023

Machine learning reveals sex-specific Alzheimer's risk genes

Research explores sex-specific gene associations in Alzheimer's disease using a machine-learning approach. It reveals immune response pathways in both sexes and stress-response pathways in males, highlighting potential biomarkers and therapeutic targets for personalized treatments.

16 May 2023

Analyzing impact of phospholipase D on the host immune response to A. fumigatus infection

Announcing a new article publication for Zoonoses journal. Aspergillus fumigatus infection in the lungs is accompanied by the recruitment of innate immune cells, phagocytosis, and the release of inflammatory factors.

11 May 2023

How antiviral host responses create a lung environment susceptible to bacterial and fungal infections

A recent study discussed coinfections in the lungs and how viral infections create a favorable environment for bacteria and fungi.

8 May 2023

Study suggests SARS-CoV-2 vaccination in pregnancy induces diverging maternal and infant cord antibody functions

Researchers explored the differences in infant and maternal cord antibody functions between SARS-CoV-2 infection and vaccination during pregnancy.

4 May 2023

Study reveals the mechanism behind oligomeric assembly of a BAR-domain-containing protein

Cell membranes play a critical role by serving as containment units and separating the inner cellular space from the extracellular environment.

26 Apr 2023

Understanding how biological sex and immune system contribute to shaping the developing brain

Researchers have established that biological sex plays a role in determining an individual's risk of brain disorders.

26 Apr 2023

Newly discovered genetic variant increases risk of developing perianal Crohn's disease

Cedars-Sinai investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease.

20 Apr 2023

How nanomedicine is revolutionizing care for cardiovascular disease

Researchers review recent advancements in nanomedicine treatment options for cardiovascular disease.

6 Apr 2023

Spike protein could be responsible for memory loss in post-COVID-19 syndrome

Patients diagnosed with post-COVID-19 syndrome often experience cognitive and memory impairments. A new study by researchers from the Federal University of Rio de Janeiro (UFRJ) and UniRio provides insight into the mechanism behind this phenomenon.

3 Apr 2023

Study indicates interleukin-6-dependant pathway dysregulation as a key druggable feature of COVID-19

Researchers identified an interleukin 6 dependent alternative pathway as a therapeutic strategy against coronavirus disease 2019.

30 Mar 2023

An apple a day keeps the doctor away: polyphenol-enriched apples alter immune cell gene expression and fecal microbiota composition

Researchers compared the effects of consuming red-fleshed apples and white-fleshed among healthy adults.

29 Mar 2023

Modulating the function of immune cells to recover aging muscle's regenerative capacity

Muscle is able to regenerate through a process that involves multiple steps and players, including the immune system.

23 Mar 2023

New biomimetic model helps study wound healing in burn and laceration wounds

Burn wounds are notoriously prone to bacterial infection and typically lead to a larger amount of scar tissue than laceration wounds.

15 Mar 2023

RBD-NTD-subunit protein vaccine provides a promising booster vaccination strategy capable of protecting against known SARS-CoV-2 variants

Researchers assessed the impact of SARS-CoV-2 spike NTD incorporation into the RBD protein vaccine.

22 Feb 2023