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Machine learning model predicts CDK4/6 inhibitor effectiveness in metastatic breast cancer

A machine learning (ML) model incorporating both clinical and genomic factors outperformed models based solely on either clinical or genomic data in predicting which patients with hormone receptor (HR)-positive, HER2-negative metastatic breast cancer would have better outcomes from adding CDK4/6 inhibitors to endocrine therapy as first-line treatment, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.

14 Dec 2024

Adjuvant anthracycline- plus taxane-based chemotherapy regimen improves survival in high-risk breast cancer patients

Patients with early-stage, node-negative, hormone receptor (HR)-positive, HER2- negative breast cancer who have a high risk of recurrence based on the OncotypeDX genomic test had better outcomes when treated with adjuvant anthracycline- plus taxane-based chemotherapy regimens compared with those receiving adjuvant taxane-based chemotherapy regimens alone, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.

14 Dec 2024

Chemical footprints of breast cancer: A new exposomics approach

Researchers in Sweden explored chemical exposures in plasma samples and uncovered links between environmental factors and breast cancer risk influenced by age, parity, and menarche.

10 Dec 2024

Study reveals brain structure differences in women with peripartum depression

Researchers have identified structural grey matter differences in the brains of women with a history of peripartum depression and those without within a group of major depressive disorder patients.

6 Dec 2024

Study shows lasting benefits of anti-hormonal therapy in postmenopausal women

Today, women with estrogen-sensitive breast cancer receive anti-hormonal therapy. Researchers now show that postmenopausal women with low-risk tumors have a long-term benefit for at least 20 years, while the benefit was more short-term for younger women with similar tumor characteristics who had not yet gone through the menopause.

3 Dec 2024

Study reveals varied risks of hormone treatments for menopausal symptoms

Researchers at Uppsala University have analyzed the effects of seven different hormone treatments for menopausal symptoms on the risk of blood clots, stroke and heart attack.

28 Nov 2024

Hormone therapy in early menopause proves safe but lacks cognitive benefits

Early menopausal hormone therapy neither benefits nor harms long-term cognition, offering reassurance but no protection against cognitive decline in healthy women.

26 Nov 2024

Researchers identify brain circuit behind sexual rejection in females

A team from the Champalimaud Foundation (CF) has pinpointed a critical neural circuit for sexual rejection, identifying a set of brain cells that play a crucial role in determining whether a female accepts or rejects mating attempts based on her reproductive cycle.

25 Nov 2024

CU Boulder study sheds light on sex differences in sleep patterns

Females sleep less, wake up more often and get less restorative sleep than males, according to a new animal study by CU Boulder researchers.

21 Nov 2024

New genetic model offers insights into breast cancer metastasis

A Michigan State University researcher's new model for studying breast cancer could help scientists better understand why and where cancer metastasizes.

11 Nov 2024

The importance of women's oral health in overall wellbeing

Women's oral health is about more than just a beautiful smile—it's a critical aspect of overall wellbeing that is often overlooked.

23 Oct 2024

Study reveals diverse lengths of luteal phases in healthy women

The current expectation is that every ovulatory menstrual cycle will have a luteal phase (the time from egg released until the next flow) that lasts approximately 14 days.

7 Oct 2024

How carnitine transporters boost reproductive health

Research uncovers the critical role of carnitine transporters in maintaining fertility by regulating energy metabolism and protecting reproductive cells from oxidative stress. It suggests new pathways for treating infertility through carnitine supplementation and targeted therapies.

6 Oct 2024

Estrogen found to promote tumor growth in breast cancers without receptors

Estrogens are known to drive tumor growth in breast cancer cells that carry its receptors, but a new study by Duke Cancer Institute researchers unexpectedly finds that estrogens play a role in fueling the growth of breast cancers without the receptors, as well as numerous other cancers.

27 Sep 2024