Protein–Protein Interactions News and Research

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Bruker announces new results in deep, unbiased plasma proteomics, PaSER 1.1 software and new cross-linking consumables at US HUPO 2021

At the virtual 17th US HUPO Conference (US HUPO 2021), Bruker Corporation (Nasdaq: BRKR) today announces progress with several collaborations in deep, unbiased plasma proteomics, leveraging the speed, sensitivity and dynamic range of 4D proteomics on timsTOF Pro systems.

From Bruker Daltonics 9 Mar 2021

Researchers develop new tool for predicting the effects of SARS-CoV-2 missense variants

A new study by a team of researchers in the UK and US describes the use of a computational tool that generates all possible single amino acid substitutions in SARS-CoV-2 and predicts their effects.

26 Feb 2021

Structure of SARS-CoV-2 envelope protein-epithelial cell junction protein complex explains virulence

A new study by researchers at Brookhaven National Laboratory and Stony Brook University in the U.S. describes the key interaction between the viral envelope (E) protein and the human cell junction protein, PALS1. The latter is necessary to establish and maintain cell polarity and tight junctions between cells.

26 Feb 2021

New approach can help treat hypertrophic cardiomyopathy with precision medicine

Hypertrophic cardiomyopathy (HCM) is a cardiovascular disease characterized by thickening of the left ventricle, otherwise known as the main squeezing chamber of the heart. HCM is best known for causing sudden death in athletes but can occur in persons of any age, often without symptoms.

26 Feb 2021

COVID-19 may alter host proteins to cause autoimmunity

To better understand the transient and chronic autoimmune symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, researchers from Memorial Sloan Kettering Cancer Center, Guizhou Medical University, and biotech company Curandis embarked on an endeavor to establish a comprehensive autoantigenome for COVID19.

23 Feb 2021

COVID-19 and lung cancer have a common pathway, say researchers

A new preprint on the bioRxiv* server describes the common features COVID-19 shares with lung cancer.

19 Feb 2021

Cone snail venom could potentially treat severe forms of malaria

Severe forms of malaria such as Plasmodium falciparum may be deadly even after treatment with current parasite-killing drugs.

18 Feb 2021

New platform could help advance genomic medicine research, drug discovery

A Cleveland Clinic-led team of researchers has developed a personalized genomic medicine platform that will help advance accelerate genomic medicine research and genome-informed drug discovery, according to new study results published recently in Genome Biology.

8 Feb 2021

Researchers find new clues to how SARS-CoV-2 infects cells

The molecular details of how SARS-CoV-2 enters cells and infects them are still not clear. Researchers at Uppsala University have tested the bioinformatic predictions made by another research group and have identified receptors that could be important players in the process.

8 Feb 2021

SARS-CoV-2 is resistant to extreme variations in temperature, finds study

A recent study from Belize and Taiwan shows that four essential proteins of SARS-CoV-2 are well adapted to habitable temperatures and exhibit extreme thermostability, which means temperature changes between the winter and summer months have a negligible effect on the viral spread.

28 Jan 2021

Rapid transmission of N501Y variants may be due to favorable effects on host receptor binding

Now, in new research posted to the preprint server bioRxiv*, scientists use an experimental structure of the Spike RBD domain co-crystallized with part of the ACE2 receptor and several in silico methods to analyze the possible impacts of three amino acid replacements (Spike K417N, E484K, N501Y) concerning ACE2 binding.

27 Jan 2021

New antiviral repurposing study finds peptides that could prevent SARS-CoV-2-ACE2 binding

A new study reports the antiviral potential of peptides against SARS-CoV-2's spike protein.

15 Jan 2021

Study reports promising new monoclonal antibody against SARS-CoV-2’s spike protein

An encouraging new study describes a promising new therapeutic antibody that shows potent neutralizing activity against SARS-CoV-2, the causative agent of COVID-19.

15 Jan 2021

Researchers develop detailed map of protein-protein interactions between SARS-CoV-2 and the host

By conducting a state-of-the-art interactome study between SARS-CoV-2 and host cells, researchers from the University of Texas MD Anderson Cancer Center in Houston identified 437 human proteins as the high-confidence interacting proteins – with substantial implications for understanding coronavirus disease 2019 (COVID-19) pathology and potential treatments.

5 Jan 2021

Protein–Protein Interactions News and Research

Bruker announces new results in deep, unbiased plasma proteomics, PaSER 1.1 software and new cross-linking consumables at US HUPO 2021

Researchers develop new tool for predicting the effects of SARS-CoV-2 missense variants

Structure of SARS-CoV-2 envelope protein-epithelial cell junction protein complex explains virulence

New approach can help treat hypertrophic cardiomyopathy with precision medicine

COVID-19 may alter host proteins to cause autoimmunity

COVID-19 and lung cancer have a common pathway, say researchers

Cone snail venom could potentially treat severe forms of malaria

New platform could help advance genomic medicine research, drug discovery

Researchers find new clues to how SARS-CoV-2 infects cells

SARS-CoV-2 is resistant to extreme variations in temperature, finds study

Rapid transmission of N501Y variants may be due to favorable effects on host receptor binding

New antiviral repurposing study finds peptides that could prevent SARS-CoV-2-ACE2 binding

Study reports promising new monoclonal antibody against SARS-CoV-2’s spike protein

Researchers develop detailed map of protein-protein interactions between SARS-CoV-2 and the host

Biologist receives NIH grant to build software tools to predict cancer drug efficacy

Hybrid approach reveals details about genes involved in Meier-Gorlin syndrome

New consortium aims to understand principles underlying the formation of coronaviruses

Predicting SARS-CoV-2 protein sequences

FASLG gene may drive cytokine-linked adverse COVID-19 outcomes with age

D614/G614 variants of SARS-CoV-2 affect neuronal transmission; G614 better at membrane fusion

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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