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Scientists identify a molecular switch that controls water flow in the gut

Although constipation and diarrhea may seem like opposite problems, they both hinge on the same underlying issue: how much fluid moves into the gut. These common issues affect millions of people in the U.S. each year, yet scientists have not fully understood what regulates intestinal fluid balance.

9 Jan 2026

Spleen-driven immune tolerance may protect transplanted organs

New research from the University of Minnesota Medical School offers a new view of how the immune system responds to organ transplants.

7 Jan 2026

BATF2: A novel tumor suppressor silenced by glutamine in head and neck cancer

A novel tumor suppressor, BATF2, can be silenced by factors in the tumor microenvironment, leading to a reduced immune response in five preclinical models of head and neck cancer, according to researchers from The University of Texas MD Anderson Cancer Center.

7 Jan 2026

TAAR1 mutation impairs brain signaling in schizophrenia

A genetic mutation passed from mother to children in families affected by schizophrenia has now been shown to completely silence a brain receptor that pharmaceutical companies are racing to target with new drugs.

6 Jan 2026

Understanding the impact of pregnancy stressors on neuroimmune landscape of the fetal brain

The maternal microbiome and immune system have both independent and synergistic effects on fetal brain health - changes in the mother's immune system have been linked to an increased risk of neurodevelopmental disorders in children.

6 Jan 2026

Repurposed drug combination shows strong promise against liver fibrosis

The study shows that this drug pair works far better together than either agent alone, offering a realistic and potentially fast path toward a new antifibrotic therapy.

6 Jan 2026

Vitamin A derivative suppresses immune response and cancer vaccine efficacy

Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by which a metabolic derivative of vitamin A-all-trans retinoic acid-compromises both the body's normal anti-cancer immune response and, in a different context, the efficacy of a promising type of cancer vaccine.

5 Jan 2026

Inhalable nanotherapy can activate the immune system against checkpoint-resistant melanoma

Immune checkpoint molecules play a crucial role in keeping the immune system in balance and preventing an attack on the body's own cells.

5 Jan 2026

Euphorbia neriifolia L. extract protects against cardiomyocyte injury and heart failure

Announcing a new publication for Acta Materia Medica journal. Heart failure (HF) remains a major global health challenge with limited therapeutic options, thus prompting the search for novel cardioprotective agents among traditional Chinese medicines.

30 Dec 2025

Reframing the role of MCL1 in cancer signaling and metabolism

A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD Faculty of Medicine provides fundamental insights into cancer biology.

22 Dec 2025

Ultra-processed foods linked to higher mortality in Black women with breast cancer

A study from Rutgers Cancer Institute researchers in eClinicalMedicine is the first to link ultra-processed foods to reduced survival in Black women with breast cancer.

18 Dec 2025

Study identifies molecular drivers of cerebral small vessel disease

A new study identifies molecular factors that promote small vessel disease - and an active drug that can restore impaired vascular functions.

16 Dec 2025

GDF3 protein sustains harmful inflammation in aging immune cells

As people age, their bodies develop a dysfunctional immune system, which can leave older adults more susceptible to conditions like sepsis.

15 Dec 2025

Single-cell RNA-seq reveals FBLN7's role in adipose tissue fibrosis

Fibrosis, resulting from excess extracellular matrix (ECM) deposition, is a feature of adipose tissue (AT) dysfunction and obesity-related insulin resistance.

13 Dec 2025

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Researchers identified trimethylamine (TMA) as a gut microbe–derived metabolite that directly inhibits IRAK4 to reduce metabolic inflammation and improve glycaemic control in high-fat-diet-fed mice. Choline-driven increases in TMA production replicated these benefits, revealing a host–microbe signaling axis with therapeutic potential for obesity-associated insulin resistance.

9 Dec 2025

Study reveals ATM kinase as the key driver of replicative senescence

After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres-the protective caps at the chromosome ends-those caps eventually become too short to prevent chromosome ends from being recognized as DNA breaks.

1 Dec 2025

Signaling Pathway News and Research

Scientists identify a molecular switch that controls water flow in the gut

Spleen-driven immune tolerance may protect transplanted organs

BATF2: A novel tumor suppressor silenced by glutamine in head and neck cancer

TAAR1 mutation impairs brain signaling in schizophrenia

Understanding the impact of pregnancy stressors on neuroimmune landscape of the fetal brain

Repurposed drug combination shows strong promise against liver fibrosis

Vitamin A derivative suppresses immune response and cancer vaccine efficacy

Inhalable nanotherapy can activate the immune system against checkpoint-resistant melanoma

Euphorbia neriifolia L. extract protects against cardiomyocyte injury and heart failure

Reframing the role of MCL1 in cancer signaling and metabolism

Ultra-processed foods linked to higher mortality in Black women with breast cancer

Study identifies molecular drivers of cerebral small vessel disease

GDF3 protein sustains harmful inflammation in aging immune cells

Single-cell RNA-seq reveals FBLN7's role in adipose tissue fibrosis

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Study reveals ATM kinase as the key driver of replicative senescence

Epigenetic drift explains why the aging intestine becomes more vulnerable to cancer

Scientists reverse aging in blood stem cells by restoring lysosome function

Breakthrough medium transforms canine stem cells into beating cardiomyocytes

Inflammatory biomarkers offer new insights for precision medicine in ischemic stroke

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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