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The crucial role of 'chaperones' in maintaining neuronal function

A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called "chaperones" are vital in ensuring that neurons can transmit signals to one another. When this neurotransmission breaks down, devastating diseases such as Alzheimer's and Parkinson's along with many others, can occur.

20 Dec 2024

Renowned neuroscientist reveals key insights into how brain circuits drive addictive behaviors

In a comprehensive Genomic Press Interview published today in Brain Medicine, renowned neuroscientist Dr. Peter Kalivas reveals crucial insights into how brain circuits drive addictive behaviors and discusses potential new drug targets for treating behavioral disorders.

17 Dec 2024

Research sheds light on how mutated PSEN2 accelerates familial Alzheimer's disease progression

Alzheimer's disease is a debilitating condition that slowly robs people of their memory and cognitive abilities, affecting millions of people worldwide.

3 Dec 2024

New discovery in the peripheral nervous system could help control obesity

An international team of researchers has discovered a new component of the peripheral nervous system that acts by increasing energy metabolism in the body.

25 Nov 2024

Pioneering protocol sheds light on NMDA receptor distribution in Alzheimer's brains

Researchers from the Institute for Neurosciences (IN), a joint center of the Miguel Hernández University of Elche (UMH) and the Spanish National Research Council (CSIC), who are also part of the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) and the Alicante Institute for Health and Biomedical Research (ISABIAL), have developed a cellular fractionation protocol.

22 Nov 2024

Advanced 3D brain models created to study memory and perception

The hippocampus is one of the most fascinating brain regions. Associated with the formation of memories, it also helps us to navigate through the world without getting lost.

22 Nov 2024

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Professor Nancy Ip discusses her groundbreaking neuroscience research, focusing on neurotrophic factors and innovative Alzheimer's disease treatment approaches.

13 Nov 2024

Understanding the role of neuroimmune cells in brain health and disease

The brain, traditionally considered an immune-privileged organ due to the blood-brain barrier (BBB), has its own sophisticated immune defense system.

6 Nov 2024

Study links brain proteins to individual differences in functional connectivity

A long-standing goal of neuroscience is to understand how molecules and cellular structures on a microscale give rise to communication between brain regions at the macroscale.

1 Nov 2024

Wayne State University researcher secures $2.3 million for Alzheimer's studies

A Wayne State University School of Medicine faculty member has been awarded a total of $2.3 million by the National Institute on Aging of the National institutes of Health for two new, concurrent projects that both address questions related to Alzheimer's disease, a progressive, age-related degenerative brain disease characterized by memory problems, impaired judgment, cognitive issues and changes in personality.

26 Oct 2024

Sleep deprivation in early life increases autism risk

Sleep deprivation in adults has long been proven to cause long-term mental and physical health issues, including, but not limited to, weakened immune systems, weight gain, depression, and increased risk of dementia.

24 Oct 2024

Uncovering human-specific genes linked to brain development and disorders

The human brain's remarkably prolonged development is unique among mammals and is thought to contribute to our advanced learning abilities.

14 Oct 2024

Unique protein complex found to influence brain function and anxiety

Scientists at Université de Montréal and its affiliated Montreal Clinical Research Institute (IRCM) have uncovered unique roles for a protein complex in the structural organization and function of brain cell connectivity, as well as in specific cognitive behaviors.

12 Oct 2024

Researchers unveil complete neuronal map of fruit fly brain

Researchers map the whole brain of Drosophila melanogaster, or the fruit fly, which comprises about 140,000 neurons and over 50 million synapses.

4 Oct 2024

New genetic mutation may cause a form of early-onset Parkinsonism

A team of scientists led by Prof. Patrik Verstreken (VIB-KU Leuven) has identified a new genetic mutation that may cause a form of early-onset Parkinsonism.

26 Sep 2024

New biomarkers offer hope for early detection and prevention of Alzheimer's

The failure to diagnose Alzheimer's disease, the most common form of dementia in the elderly, at an early stage of molecular pathology is considered a major reason why treatments fail in clinical trials. Previous research to molecularly diagnose Alzheimer's disease yielded "A/T/N" central biomarkers based on the measurements of proteins, β-amyloid ("A") and tau ("T"), and "N" encompassing neurodegeneration. A/T/N can be measured in brain tissue, by in vivo brain imaging techniques, and by analysis of cerebrospinal fluid and plasma.

18 Sep 2024