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Twenty-five million Americans suffer from ulcers. An ulcer is a sore or hole in the lining of the stomach or duodenum (the first part of the small intestine). People of any age can get an ulcer and women are affected just as often as men.

Helicobacter pylori (H. pylori) is a bacterium that lives on the lining of the stomach. Although we used to think that spicy food, acid, and stress were the major causes of ulcers, we now know that nine out of ten ulcers are caused by H. pylori. Medicines that reduce stomach acid may make you feel better, but your ulcer may come back. Here's the good news: Since most ulcers are caused by this bacterial infection, they can be cured with the right antibiotics.

Disparities in major leg amputation and mortality for patients with diabetic foot ulcers

A new study published in JAMA Network Open aimed to identify how intersectionality among race, ethnicity, rurality, and neighborhood disadvantage can result in high risks of major leg amputations and death among Medicare beneficiaries who were hospitalized with diabetic foot ulcers.

24 Apr 2022

Study: Many older adults are not prescribed disease-modifying drugs for rheumatoid arthritis

Despite guidelines that call for early and aggressive treatment of rheumatoid arthritis, a new study suggests many older adults are not prescribed disease-modifying medications for their inflammatory autoimmune disease.

8 Apr 2022

Acute respiratory distress syndrome may increase death risk among young COVID-19 patients

A new study estimated the risk and prevalence of acute respiratory distress syndrome in hospitalized young adults with SARS-CoV-2 infection.

4 Apr 2022

Researchers develop footwear technology to prevent diabetic foot ulcers

To prevent diabetic foot ulcers, research scientists at The University of Texas at Arlington have developed footwear technology that relieves pressure on areas of the feet that experience high stress during walking and other activities.

31 Mar 2022

WHO and Sanofi sign new agreement to sustain specific efforts to eliminate NTDs

The World Health Organization (WHO) and Sanofi – one of the world's leading pharmaceutical companies – have signed a new agreement for donations of medicines to sustain specific efforts to eliminate neglected tropical diseases (NTDs).

16 Dec 2021

ERs are swamped with seriously ill patients, although many don’t have covid

Inside the emergency department at Sparrow Hospital in Lansing, Michigan, staff members are struggling to care for patients showing up much sicker than they’ve ever seen.

29 Oct 2021

NUS scientists develop a smart bandage to monitor chronic wounds

A research team led by Professor Lim Chwee Teck from the National University of Singapore's Department of Biomedical Engineering and Institute for Health Innovation & Technology, in collaboration with clinical partners from Singapore General Hospital, has developed a smart wearable sensor that can conduct real-time, point-of-care assessment of chronic wounds wirelessly via an app.

21 Oct 2021

Study reveals unique molecular mechanisms of stomach’s acid pump

Nagoya University researchers and colleagues have improved understanding of the molecular mechanisms of a key protein that makes the stomach acidic. Their findings, published in the journal Nature Communications, could lead to better drugs for stomach ulcers and shed light on the functions of similar proteins across the human body.

15 Oct 2021

Aquaporin 5 induction may be a potential therapy to accelerate resurfacing of corneal defects

Corneal defects often heal themselves, but serious injuries that are left untreated can result in inflammation, infection, ulceration and even blindness.

30 Sep 2021

Researchers investigate how CBD could play a therapeutic role in oral ulcer

Xingying Qi, West China Hospital of Stomatology, Sichuan University, Chengdu, China, presented the oral session "Cannabidiol Promotes Oral Ulcer Healing by Inactivating CMPK2-Mediated NLRP3 Inflammasome" at the virtual 99th General Session & Exhibition of the International Association for Dental Research, held in conjunction with the 50th Annual Meeting of the American Association for Dental Research and the 45th Annual Meeting of the Canadian Association for Dental Research, on July 21-24, 2021.

22 Jul 2021

A low-cost biopolymer dressing to help heal chronic wounds

Tens of millions of patients around the world suffer from persistent and potentially life-threatening wounds. These chronic wounds, which are also a leading cause of amputation, have treatments, but the cost of existing wound dressings can prevent them from reaching people in need.

19 Jul 2021

Structural analogs of triterpenoids show strong inhibitory activity against coronaviruses

In a recent study published in the journal Pathogens, researchers carried out a molecular docking study for 17 structural analogs prepared from natural maslinic and oleanolic acids and screened them against SARS-CoV-2 main protease. They also experimentally validated the data by determining the half-maximal cytotoxic and inhibitory concentrations of each of the 17 compounds. The researchers investigated whether the compound with antiviral activity affected viral adsorption, replication, or viricidal effect using a plaque infectivity reduction assay.

9 Jun 2021

Low-profile thoracic aortic endograft minimizes complications, increases patient pool

Preliminary results of a clinical trial, presented today at the AATS 101st Annual Meeting, showed that a new, low-profile thoracic aortic endograft is safe and effective in the treatment of descending thoracic aortic aneurysm or penetrating atherosclerotic ulcer (PAU) diseases.

3 May 2021

New stem cell therapy shows promise to prevent diabetes-related amputations

According to the results of a phase 1 clinical trial just published in STEM CELLS Translational Medicine, a new stem cell therapy shows promise of making diabetes-related amputations a thing of the past.

7 Apr 2021

New 'care bundle' can reduce PPE-related facial injuries in frontline COVID-19 healthcare workers

A study has found that a new 'care bundle' can reduce the incidence of facial pressure injuries in frontline COVID-19 healthcare workers caused by the prolonged wearing of Personal Protective Equipment (PPE).

23 Mar 2021

Study reveals new approach for treating diabetic foot ulcers

A discovery involving multiple teams from across Scripps Research has revealed a powerful new approach for treating diabetic foot ulcers, which affect millions of people in the US and often lead to serious complications.

23 Mar 2021

Dandelion extract inhibits SARS-CoV-2 in vitro

An exciting new study describes a specific inhibitor of the SARS-CoV-2 found in an extract of the common dandelion that could provide a new and fruitful avenue of drug research.

23 Mar 2021

World's largest study of genetic factors reveals link between depression and stomach ulcers

University of Queensland researchers have confirmed a link between depression and stomach ulcers, in the world's largest study of genetic factors in peptic ulcer disease.

25 Feb 2021

Cissampelos pareira L. extracts demonstrate anti-SARS-CoV-2 activity in vitro

A team of scientists from India has recently investigated the antiviral potency of a traditional medicinal plant Cissampelos pareira L. in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The findings reveal that both whole-plant extracts and bioactive compounds can inhibit SARS-CoV-2 replication by modulating estrogen receptor 1 (ESR1) activity.

21 Feb 2021

Regular walnut intake may help protect against negative outcomes associated with H. pylori infection

A new animal study, published in the Journal of Clinical Biochemistry and Nutrition, suggests regular walnut consumption may be a promising intervention for reducing negative outcomes associated with Helicobacter pylori (H. pylori) infection, a widespread bacterial infection that affects more than half of the world's population.

9 Feb 2021

Ulcer News and Research

Disparities in major leg amputation and mortality for patients with diabetic foot ulcers

Study: Many older adults are not prescribed disease-modifying drugs for rheumatoid arthritis

Acute respiratory distress syndrome may increase death risk among young COVID-19 patients

Researchers develop footwear technology to prevent diabetic foot ulcers

WHO and Sanofi sign new agreement to sustain specific efforts to eliminate NTDs

ERs are swamped with seriously ill patients, although many don’t have covid

NUS scientists develop a smart bandage to monitor chronic wounds

Study reveals unique molecular mechanisms of stomach’s acid pump

Aquaporin 5 induction may be a potential therapy to accelerate resurfacing of corneal defects

Researchers investigate how CBD could play a therapeutic role in oral ulcer

A low-cost biopolymer dressing to help heal chronic wounds

Structural analogs of triterpenoids show strong inhibitory activity against coronaviruses

Low-profile thoracic aortic endograft minimizes complications, increases patient pool

New stem cell therapy shows promise to prevent diabetes-related amputations

New 'care bundle' can reduce PPE-related facial injuries in frontline COVID-19 healthcare workers

Study reveals new approach for treating diabetic foot ulcers

Dandelion extract inhibits SARS-CoV-2 in vitro

World's largest study of genetic factors reveals link between depression and stomach ulcers

Cissampelos pareira L. extracts demonstrate anti-SARS-CoV-2 activity in vitro

Regular walnut intake may help protect against negative outcomes associated with H. pylori infection

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