Apoptosis News and Research

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Apoptosis is programmed cell death, the body's normal method of disposing of damaged, unwanted, or unneeded cells.

TSC1 status may predict response to Hsp90 inhibitors in bladder cancer patients

The researchers have recently identified the tumor suppressor tuberous sclerosis complex 1 as a new co-chaperone of Hsp90 that affects Hsp90 binding to its inhibitors.

10 Oct 2019

Cell death 'blocker' could speed recovery and save lives

Scientists in Australia have shown that they can successfully stop the process of cell death (apoptosis) through a revolutionary new compound.

9 Oct 2019

Targeting HDAC2 reduces MDM2 expression and has anti-tumor effects in dedifferentiated liposarcoma

The cover for issue 55 of Oncotarget features Figure 3, "Romidepsin exhibits anti-tumor effect in xenograft model of DDLPS," by Seligson, et al.

4 Oct 2019

HIV-1 Tat expression leads to perturbations in cellular protein expression, research suggests

The cover for issue 54 of Oncotarget features Figure 2, "Comparative proteomic profiling of the peptides/proteins identified from 293T, IL16lamp2b and mExo-Tat samples," by Lu, et al.

4 Oct 2019

Adding local anesthetics can improve treatment for incurable breast cancer, melanoma

A new study examined the effects of local anesthetics combined with standard chemotherapy for treatment of incurable triple-negative breast cancer, as well as melanoma.

3 Oct 2019

New trial shows improved survival for patients with advanced colorectal BRAF-mutant cancer

A clinical trial has shown that using a combination of three drugs that target a BRAF gene mutation in patients with mCRC effectively boosts overall survival.

30 Sep 2019

Toxin may play key role in promoting transmission of deadly E. coli strains in cattle

Shiga toxin subtype 2a (Stx2a) may play a key role in promoting the colonization and transmission of life-threatening Escherichia coli strains in cattle, according to a study published October 3 in the open-access journal PLOS Pathogens by Tom McNeilly of the Moredun Research Institute, David Gally of the University of Edinburgh, and colleagues.

From PLOS ONE 27 Sep 2019

Onion and garlic may reduce risk of breast cancer

Onion and garlic are staple spices for many cuisines across the globe. There are numerous recipes requiring these two elements, and they may now be key ingredients in cutting the risk of breast cancer.

24 Sep 2019

Vaping destroys lining and immune cells in the lung, says study

Now, a new study shows that the vapor emitted by the electronic cigarettes is vaping is linked to much higher rates of cell death among airway epithelial cells – more than double, from about 9% in controls to 17-20% in the exposed cells.

24 Sep 2019

New study identifies potential enzyme target for diabetic retinopathy

A new study shows that diabetic retinopathy (DR), or retinal disease caused by the high blood glucose levels in diabetes mellitus, is due to the death of retinal cells because of the high levels of a pro-enzyme called lysyl oxidase propeptide (LOX-PP). This could help researchers develop specific treatments by targeting this molecule.

22 Sep 2019

Researchers discover potential approach to treating diabetic retinopathy

Boston University researchers have identified an enzymatic precursor that is toxic to retinal cells and could be used in new treatments for diabetic retinopathy.

20 Sep 2019

Alzheimer’s drug an interesting candidate for the treatment of parasitic Chagas disease

Researchers have discovered that an Alzheimer's drug could serve as a starting point in treating Chagas disease.

20 Sep 2019

Scientists identify pathway for treatment-resistant lung cancer

A big way chemotherapy works is by prompting cancer cells to commit suicide, and scientists have found a pathway the most common lung cancer walks to avoid death.

20 Sep 2019

New protein could offer a fresh target for cancer treatment

A study has revealed a drug target called the mitoNEET cell protein, which determines how materials are transported from the mitochondria to the rest of the cell.

19 Sep 2019

New method developed to address failures in promising anti-cancer drug

Biomedical engineers at Duke University have developed a method to address failures in a promising anti-cancer drug, bringing together tools from genome engineering, protein engineering and biomaterials science to improve the efficacy, accuracy and longevity of certain cancer therapies.

17 Sep 2019

Physical activity may attenuate unfavorable atherogenic changes in menopausal women

A new study on menopausal women shows that leisure-time physical activity is associated with a healthier blood lipid profile. However, results suggest that leisure-time physical activity does not seem to entirely offset the unfavorable lipid profile changes associated with the menopausal transition.

13 Sep 2019