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Novel cancer immunotherapy compound degrades an enzyme found in cancer cells and T cells

Researchers in Purdue University's College of Pharmacy are leveraging the dual roles played by an enzyme found in both cancer cells and T cells to create a novel cancer immunotherapy compound.

14 Nov 2023

Discovery of two new enzymes offers easier ways to study and manufacture complex natural chemicals

Slumbering among thousands of bacterial strains in a collection of natural specimens at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, several fragile vials held something unexpected, and possibly very useful.

13 Nov 2023

Exploring the use of psychedelics as novel treatments for psychiatric disorders

Psychedelic compounds such as psilocybin, a substance found in various mushroom species, are garnering more research support as novel treatments for psychiatric disorders, but questions remain concerning who they may help the most.

13 Nov 2023

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

In this study, researchers harnessed crowdsourcing and open science to develop new antivirals against SARS-CoV-2, focusing on its main protease, Mpro. Their approach led to the discovery of potent compounds, including one with high efficacy in cell lines and cross-reactivity against various COVID-19 variants, demonstrating the potential of collaborative and transparent drug discovery in tackling global health crises.

12 Nov 2023

Pediatric viral threats surge in the 21st century: A call for One Health approach

Scoping review in "Pediatric Research" examines the rise of pediatric viral diseases in the 21st century and underscores the importance of a One Health approach, integrating human, animal, and ecosystem health, to combat these emerging and re-emerging infectious threats effectively.

9 Nov 2023

Open-science drug discovery campaign yields a wealth of data on SARS-CoV-2 main protease

Although the group's work has been freely available since its inception in March 2020, the COVID Moonshot Consortium is finally formally reporting their results.

9 Nov 2023

Preclinical discovery could point the way toward better treatments for type 2 diabetes

A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes, according to a new study by Weill Cornell Medicine investigators.

9 Nov 2023

COVID Moonshot Consortium makes major breakthrough in antiviral drug discovery

The work of the COVID Moonshot Consortium is being published in the prestigious journal Science on 10 November, revealing their discovery of a potent SARS-CoV-2 antiviral lead compound.

9 Nov 2023

Scientists discover kidney-friendly antifungal that evades resistance

In this investigation, researchers produced powerful antifungals of the polyene class without nephrotoxicity.

9 Nov 2023

Broccoli sprouts diet protects mice from Crohn's disease, study shows

High fiber diets, like those that include broccoli sprouts or other cruciferous vegetables, may reduce disease symptoms and improve quality of life in patients with inflammatory bowel disease (IBD), according to a study conducted in mice.

9 Nov 2023

Scientists develop tissue adhesive gelatin hydrogels to speed up wound healing, prevent infections

Open wounds, whether caused by accidents or from medical procedures like surgery, require proper management to speed up healing and prevent infections.

6 Nov 2023

Industry & academia combine to support synthesis of squaric acid monoamides as building blocks for drug discovery

Asynt have collaborated with Kingston University and Key Organics to develop an accessible new synthetic compound library.

From Asynt 5 Nov 2023

State-by-state snapshot: Long-COVID's grip varies, with mental health in the crosshairs

Study shows 14% of Americans face long-COVID with variations across states and ethnicities, linking it to significant declines in physical and mental health.

5 Nov 2023

Butterfly-inspired imaging sensor can detect cancer cells with high accuracy

There are many creatures on our planet with more advanced senses than humans. Turtles can sense Earth's magnetic field. Mantis shrimp can detect polarized light.

3 Nov 2023

Citrus compounds show zesty promise in type 2 diabetes management

Citrus compounds show promise in type 2 diabetes management, reducing blood glucose and mitigating metabolic complications without a clear threshold in humans for bioflavonoid efficacy.

2 Nov 2023

Marijuana-like compound shows promise as new treatment for skin lupus

A marijuana-like compound holds out promise as a new treatment for a severe autoimmune skin disease called skin lupus, according to a study published recently by a multicenter team including researchers at the George Washington University.

2 Nov 2023

Industry & academia combine to support synthesis of squaric acid monoamides as building blocks for drug discovery

Global sustainable laboratory equipment visionaries, Asynt, have collaborated with Kingston University (London, UK) and renowned worldwide chemical products supplier, Key Organics, to develop an accessible new synthetic compound library.

From Asynt 2 Nov 2023

The development of a machine-learned scoring function of human preference in the context of early drug discovery campaigns

In a recent study published in Nature Communications, researchers developed a scoring mechanism based on artificial intelligence for early drug discovery campaigns that might be utilized for compound prioritizing, motif rationalization, and biased drug design.

1 Nov 2023

From Cells to Drugs: How Cell Painting is Transforming Drug Discovery

In this interview, Jordi Carreras delves into the fascinating world of Cell Painting, a powerful technology gaining momentum in drug discovery. He shares insights into his groundbreaking research, the unique aspects of Phenaros' drug discovery platform, and the synergy between academia and industry.

From ELRIG (UK) Ltd. 1 Nov 2023

Moringa-infused gluten-free sourdough offers health boost for all, especially celiacs

Researchers have developed a gluten-free sourdough bread fortified with Moringa oleifera, an unconventional crop known for its health benefits. The study found that this novel bread formulation offers enhanced nutritional content, including higher levels of protein and essential minerals, making it a viable option for people with celiac disease and those seeking healthier bread alternatives.

30 Oct 2023

Compound News and Research

Novel cancer immunotherapy compound degrades an enzyme found in cancer cells and T cells

Discovery of two new enzymes offers easier ways to study and manufacture complex natural chemicals

Exploring the use of psychedelics as novel treatments for psychiatric disorders

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

Pediatric viral threats surge in the 21st century: A call for One Health approach

Open-science drug discovery campaign yields a wealth of data on SARS-CoV-2 main protease

Preclinical discovery could point the way toward better treatments for type 2 diabetes

COVID Moonshot Consortium makes major breakthrough in antiviral drug discovery

Scientists discover kidney-friendly antifungal that evades resistance

Broccoli sprouts diet protects mice from Crohn's disease, study shows

Scientists develop tissue adhesive gelatin hydrogels to speed up wound healing, prevent infections

Industry & academia combine to support synthesis of squaric acid monoamides as building blocks for drug discovery

State-by-state snapshot: Long-COVID's grip varies, with mental health in the crosshairs

Butterfly-inspired imaging sensor can detect cancer cells with high accuracy

Citrus compounds show zesty promise in type 2 diabetes management

Marijuana-like compound shows promise as new treatment for skin lupus

Industry & academia combine to support synthesis of squaric acid monoamides as building blocks for drug discovery

The development of a machine-learned scoring function of human preference in the context of early drug discovery campaigns

From Cells to Drugs: How Cell Painting is Transforming Drug Discovery

Moringa-infused gluten-free sourdough offers health boost for all, especially celiacs

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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