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Probiodrug AG, collaborators explain interplay of key suspects in Alzheimer’s

Probiodrug AG (Probiodrug), a biotech company developing products for the treatment of neurodegenerative and inflammatory diseases with a particular focus on Alzheimer's disease (AD), today announced its scientists and academics collaborators published seminal findings on the role of pyroglu Aβ in AD pathology in the May 2, 2012 online edition of the journal Nature (DOI: 10.1038/nature11060). The new findings add to the growing body of evidence that pyroglu Aβ plays a crucial role in the initiation of AD. In addition, the research results further elucidate the mechanism by which pyroglu Aβ triggers neuronal toxicity.

3 May 2012

Scientists determine structure of green pigment seen in nitrite-cured bacon, other meats

As with many concerned consumers, a team of University of Oklahoma researchers wondered if the green color sometimes seen in bacon is, in fact, harmful to human health. Recently, these OU scientists took an important first step in answering this question by determining the structure of the green pigment responsible for this 'nitrite burn.'

3 May 2012

Foods rich in omega-3 fatty acids linked with lower blood beta-amyloid levels

A new study suggests that eating foods that contain omega-3 fatty acids, such as fish, chicken, salad dressing and nuts, may be associated with lower blood levels of a protein related to Alzheimer's disease and memory problems.

3 May 2012

PRDM16 transcription co-factor plays a critical role in development of embryonic palate

In the United States, a baby is born with a facial cleft every hour, of every day of the year! Such birth defects result from both gene mutations and environmental insults. PRDM16 is a transcription factor originally described as being aberrantly activated in specific types of leukemia's, and more recently as a master regulator of brown adipose tissue differentiation.

3 May 2012

Study confirms that COX-2 inhibitors predispose people to cardiovascular disease

After nearly 13 years of study and intense debate, a pair of new papers from the Perelman School of Medicine, at the University of Pennsylvania have confirmed exactly how a once-popular class of anti-inflammatory drugs leads to cardiovascular risk for people taking it.

3 May 2012

Grape-derived compound may prevent neurodegenerative disorders involving tau neuropathology

Researchers at Mount Sinai School of Medicine have gained insight into the mechanism by which a pathological brain protein called tau contributes to the progression of Alzheimer's disease (AD) and other neurodegenerative disorders. This finding, published in the most recent issue of the Journal of Biological Chemistry, may provide the basis for future investigations on how to prevent tau from damaging brain circuits involved in cognitive function.

2 May 2012

Expression of tyrosine kinases may limit effectiveness of agents against sarcomas

To better understand the signaling pathways active in sarcomas, researchers at Moffitt Cancer Center used state-of-the-art mass spectrometry-based proteomics to characterize a family of protein enzymes that act as "on" or "off" switches important in the biology of cancer. The tyrosine kinases they identified, the researchers said, could act as "drivers" for the growth and survival of sarcomas.

2 May 2012

Cell-based test to discover molecules for treatment of ER-positive breast cancer

Cancer Research UK and its commercial arm, Cancer Research Technology have developed a unique test to discover molecules that could lead to potential new treatments for oestrogen receptor (ER)-positive breast cancer.

2 May 2012

Scientists identify how cell architecture changes during formation of gametes

Scientists using high-powered microscopes have made a stunning observation of the architecture within a cell - and identified for the first time how the architecture changes during the formation of gametes, also known as sex cells, in order to successfully complete the process.

2 May 2012

Researchers discover how protein ARTD1's DNA recruitment is regulated during inflammation

During inflammation, controlled gene expression is necessary in order to allow the organism to mount an effective defense response. For this process, the protein ARTD1 is removed from the DNA.

2 May 2012

Two MSU researchers invent protein purifier for pharma companies

Two Michigan State University researchers have invented a protein purifier that could help pharmaceutical companies save time and money.

2 May 2012

Experts identify new gene that could help development of human fertility treatments

Experts from Durham University have identified a new gene that could help the development of fertility treatments in humans in the future.

2 May 2012

NKCC1 protein may hold clues to how glioblastoma moves and invades

Johns Hopkins researchers have discovered that a protein that transports sodium, potassium and chloride may hold clues to how glioblastoma, the most common and deadliest type of brain cancer, moves and invades nearby healthy brain tissue.

2 May 2012

Weight loss reduces inflammation in postmenopausal women

Postmenopausal women who were overweight or obese and lost at least 5 percent of their body weight had a measurable reduction in markers of inflammation, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.

2 May 2012

Tyrosine kinases could act as drivers for growth and survival of sarcomas

2 May 2012

Pfizer receives FDA approval for Elelyso to treat Type 1 Gaucher disease

The U.S. Food and Drug Administration today approved Elelyso (taliglucerase alfa) for long-term enzyme replacement therapy to treat a form of Gaucher disease, a rare genetic disorder.

2 May 2012

Reducing levels of SUN1 protein increases life span of mice with progeria, heart disease

Scientists have discovered that they can dramatically increase the life span of mice with progeria (premature ageing disease) and heart disease (caused by Emery-Dreifuss muscular dystrophy) by reducing levels of a protein called SUN1.

30 Apr 2012

Antibody that neutralizes enzyme Kallikrein 6 staves off MS

Researchers studying multiple sclerosis(MS) have long been looking for the specific molecules in the body that cause lesions in myelin, the fatty, insulating cells that sheathe the nerves.

30 Apr 2012

Protein vital for cell survival and immune balance has another form with different function

Research led by St. Jude Children's Research Hospital investigators suggests that safeguarding cell survival and maintaining a balanced immune system is just the start of the myeloid cell leukemia sequence 1 (MCL1) protein's work.

30 Apr 2012

Human iPS cells accrue genetic changes at about the same rate as replicating cells

A team of researchers from Johns Hopkins University and the National Human Genome Research Institute has evaluated the whole genomic sequence of stem cells derived from human bone marrow cells—so-called induced pluripotent stem (iPS) cells—and found that relatively few genetic changes occur during stem cell conversion by an improved method.

30 Apr 2012

G Protein News and Research

Probiodrug AG, collaborators explain interplay of key suspects in Alzheimer’s

Scientists determine structure of green pigment seen in nitrite-cured bacon, other meats

Foods rich in omega-3 fatty acids linked with lower blood beta-amyloid levels

PRDM16 transcription co-factor plays a critical role in development of embryonic palate

Study confirms that COX-2 inhibitors predispose people to cardiovascular disease

Grape-derived compound may prevent neurodegenerative disorders involving tau neuropathology

Expression of tyrosine kinases may limit effectiveness of agents against sarcomas

Cell-based test to discover molecules for treatment of ER-positive breast cancer

Scientists identify how cell architecture changes during formation of gametes

Researchers discover how protein ARTD1's DNA recruitment is regulated during inflammation

Two MSU researchers invent protein purifier for pharma companies

Experts identify new gene that could help development of human fertility treatments

NKCC1 protein may hold clues to how glioblastoma moves and invades

Weight loss reduces inflammation in postmenopausal women

Tyrosine kinases could act as drivers for growth and survival of sarcomas

Pfizer receives FDA approval for Elelyso to treat Type 1 Gaucher disease

Reducing levels of SUN1 protein increases life span of mice with progeria, heart disease

Antibody that neutralizes enzyme Kallikrein 6 staves off MS

Protein vital for cell survival and immune balance has another form with different function

Human iPS cells accrue genetic changes at about the same rate as replicating cells

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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