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Bacterial DNA more likely to integrate in the genome of tumors than in normal healthy cells

Bacterial DNA may integrate into the human genome more readily in tumors than in normal human tissue, according to a new study from the University of Maryland School of Medicine's Institute for Genome Sciences. Researchers analyzed genomic sequencing data available from the Human Genome Project, the 1,000 Genomes Project and The Cancer Genome Atlas (TCGA). They considered the phenomenon of lateral gene transfer (LGT), the transmission of genetic material between organisms in the absence of sex.

21 Jun 2013

MPIIB researchers show that Chlamydia infections can cause mutations in host DNA

Chlamydia trachomatis is a human pathogen that is the leading cause of bacterial sexually transmitted disease worldwide with more than 90 million new cases of genital infections occurring each year. About 70 percent of women infected with Chlamydia remain asymptomatic and these bacteria can establish chronic infections for months, or even years. Even when it causes no symptoms, Chlamydia can damage a woman's reproductive organs. In addition, standard antibacterial drugs are proving increasingly ineffective in complete eradication, as Chlamydia goes in to persistent mode, leading to asymptomatic chronic infection.

21 Jun 2013

Scientists use stem-cell technology to create research cell line from PDAC patient

Pancreatic cancer carries a dismal prognosis. According to the National Cancer Institute, the overall five-year relative survival for 2003-2009 was 6 percent.

21 Jun 2013

Genetic process that promotes cervical cancer warns about anti-viral therapies in certain cases

A new understanding of the genetic process that can lead to cervical cancer may help improve diagnosis of potentially dangerous lesions for some women, and also raises a warning flag about the use of anti-viral therapies in certain cases - suggesting they could actually trigger the cancer they are trying to cure.

20 Jun 2013

Scientists create way to see structures that store memories in living brain

Oscar Wilde called memory "the diary that we all carry about with us." Now a team of scientists has developed a way to see where and how that diary is written.

20 Jun 2013

Aspirin slows accumulation of DNA mutations in abnormal cells, points UCSF scientist

Aspirin is known to lower risk for some cancers, and a new study led by a UC San Francisco scientist points to a possible explanation, with the discovery that aspirin slows the accumulation of DNA mutations in abnormal cells in at least one pre-cancerous condition.

19 Jun 2013

UCSC experts awarded $3.5M NIH grant to develop cancer genomics tools

Despite some successes, predicting cancer outcomes based on the molecular signatures in cancer cells remains a major challenge. A new effort, funded by the National Cancer Institute and led by researchers at the University of California, Santa Cruz, aims to clear several key roadblocks that have stymied progress in this field.

18 Jun 2013

IDC announces recipients of HPC Innovation Excellence Award at ISC'13

International Data Corporation today announced the fifth round of recipients of the HPC Innovation Excellence Award at the ISC'13 supercomputer industry conference in Leipzig, Germany. Prior winners were announced at the ISC'11, SC'11, ISC'12, and SC'12 supercomputing conferences.

18 Jun 2013

Genomic instability in new molecular pathway may predict worse outcomes in breast cancer patients

A new molecular pathway involving the gene ZNF365 has been identified and abnormalities in that pathway may predict worse outcomes for patients with breast cancer, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.

18 Jun 2013

New technique offers potential to screen patients for viruses

In research published in Biochemical and Biophysical Research Communications, Saint Louis University researchers describe a technology that can detect new, previously unknown viruses. The technique offers the potential to screen patients for viruses even when doctors have not identified a particular virus as the likely source of an infection.

18 Jun 2013

Patients with central nervous system infections may suffer from the effects of CyCV-VN virus: Study

Patients in Vietnam and other locations with central nervous system infections may well be suffering from the effects of a newly discovered virus, according to a study to be published in mBio-, the online open-access journal of the American Society for Microbiology.

18 Jun 2013

MGH researchers discover CNVs in members of 10 families with early-onset Alzheimer's

Although a family history of Alzheimer's disease is a primary risk factor for the devastating neurological disorder, mutations in only three genes - the amyloid precursor protein and presenilins 1 and 2 - have been established as causative for inherited, early-onset Alzheimer's, accounting for about half of such cases.

18 Jun 2013

Researchers produce first genome-wide investigation of cap-independent translation

Because of their central importance to biology, proteins have been the focus of intense research, particularly the manner in which they are produced from genetically coded templates-a process commonly known as translation. While the general mechanism of translation has been understood for some time, protein synthesis can initiate by more than one mechanism. One of the least well understood mechanisms is known as cap-independent translation.

17 Jun 2013

Researchers identify genetic mutation responsible for MDP Syndrome

National Paracycling Champion Tom Staniford has an extremely rare condition which, until now, has puzzled his doctors. He is unable to store fat under his skin - yet has type 2 diabetes - and suffered hearing loss as a child. Now, thanks to advances in genome sequencing, an international research team led by the University of Exeter Medical School has identified Tom's condition and pinpointed the single genetic mutation that causes it.

17 Jun 2013

Comparison of 1,000-year-old and modern bacterial genomes provides insights into history of leprosy pathogen

From skeletons and biopsies, an international team of scientists was successful in reconstructing a dozen medieval and modern genomes of the leprosy-causing bacteria Mycobacterium leprae.

15 Jun 2013

Supreme Court DNA ruling leaves questions unanswered

Editorial boards weigh in on what Thursday's Supreme Court ruling means for medical research and for the medical industry.

15 Jun 2013

HandsFree system helps analyze next generation sequencing data

In the early 1990s, an international effort was launched by the U.S. Department of Energy and the National Institutes of Health to sequence the human genome. The project took 13 years, involved many scientists in several countries, and cost $2.7 billion (in FY 1991) dollars.

15 Jun 2013

Ottawa researchers say advanced mathematical modeling can be used to fight against cancer

Here's a good reason to pay attention in math class. Nature Communications has published a paper from Ottawa researchers today, outlining how advanced mathematical modelling can be used in the fight against cancer.

14 Jun 2013

Gene variants may predict which women are most likely to benefit from breast cancer therapy

In women at high risk for breast cancer, a long-term drug treatment can cut the risk of developing the disease in half. Researchers supported by the National Institutes of Health have now identified two gene variants that may predict which women are most likely to benefit from this therapy—and which should avoid it.

14 Jun 2013

Johns Hopkins scientists receive grants to research on genome-based test for cancer

An anonymous donor has given $500,000 to conduct large-scale clinical trials and laboratory research on the "PapGene" test, a genomic-based screening test that detects ovarian and endometrial cancers in cervical fluid.

14 Jun 2013

Genome News and Research

Bacterial DNA more likely to integrate in the genome of tumors than in normal healthy cells

MPIIB researchers show that Chlamydia infections can cause mutations in host DNA

Scientists use stem-cell technology to create research cell line from PDAC patient

Genetic process that promotes cervical cancer warns about anti-viral therapies in certain cases

Scientists create way to see structures that store memories in living brain

Aspirin slows accumulation of DNA mutations in abnormal cells, points UCSF scientist

UCSC experts awarded $3.5M NIH grant to develop cancer genomics tools

IDC announces recipients of HPC Innovation Excellence Award at ISC'13

Genomic instability in new molecular pathway may predict worse outcomes in breast cancer patients

New technique offers potential to screen patients for viruses

Patients with central nervous system infections may suffer from the effects of CyCV-VN virus: Study

MGH researchers discover CNVs in members of 10 families with early-onset Alzheimer's

Researchers produce first genome-wide investigation of cap-independent translation

Researchers identify genetic mutation responsible for MDP Syndrome

Comparison of 1,000-year-old and modern bacterial genomes provides insights into history of leprosy pathogen

Supreme Court DNA ruling leaves questions unanswered

HandsFree system helps analyze next generation sequencing data

Ottawa researchers say advanced mathematical modeling can be used to fight against cancer

Gene variants may predict which women are most likely to benefit from breast cancer therapy

Johns Hopkins scientists receive grants to research on genome-based test for cancer

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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