Protein C News and Research

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Deactivating the cancer-causing protein by cutting off other proteins that activate it

In a line of dominos, if you take out a single piece, the last one will never fall. Similarly, a lot of pieces have to line up and be pushed at the same time in a cell to result in cancer.

1 Dec 2021

Fourth shot of Moderna COVID vaccine improves Delta variant neutralization in kidney transplant patients

New research suggests that a fourth dose of the mRNA-1273 vaccine in kidney transplant recipients improves Delta variant serum neutralization.

1 Dec 2021

Fast-tracked human stroke drug may also be a safe and powerful defense against dementia

A human stroke drug, fast-tracked by the Food and Drug Administration and soon entering Phase 3 clinical trials, shows intriguing signs that it might also be a safe and powerful defense against Alzheimer's and other forms of dementia.

1 Dec 2021

Neural network 'hallucinates' proteins with new, stable structures

Just as convincing images of cats can be created using artificial intelligence, new proteins can now be made using similar tools. In a report in Nature, a team including researchers at the University of Washington, Rensselaer Polytechnic Institute, and Harvard University describe the development of a neural network that "hallucinates" proteins with new, stable structures.

1 Dec 2021

Structure function analysis of potent antibodies against Beta SARS-CoV-2 variant

A team of researchers from UK and US institutions created a large panel of mAbs derived from memory B cells of convalescent Beta subjects to better understand the antigenic landscape of Beta.

1 Dec 2021

Plant-derived virus-like particle vaccines against SARS-CoV-2

In a review published in Biotechnology Letters, the authors discuss plant-derived VLP-based vaccines.

1 Dec 2021

DNA sequencing of residual disease accurately identifies leukemia patients who would relapse

In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection of residual disease between three and 12 months accurately identified all patients who would eventually relapse, while other methods were less predictive.

1 Dec 2021

Impact of SARS-CoV-2 on oral health

New research examined SARS-CoV-2 and its impact on oral health and suggests that survival against the infection may be partially dependent on such factors.

1 Dec 2021

Role of interferon type I-driven responses associated with disease control in COVID-19

New research suggests that treatment with type I interferons in the early stage of COVID-19 may supress disease progression by limiting SARS-CoV-2 in hosts.

1 Dec 2021

Novel nanopore technique for annotation of SARS-CoV-2 capping sites and understanding sgRNA structure

New research examined SARS-CoV-2 transcripts in order to understand how it expresses its gene products in the infected host.

1 Dec 2021

Scientists identify new genes associated with familial Meniere's disease

A team of scientists from the University of Granada (UGR) and GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research—led by Pablo Roman-Naranjo and Jose Antonio López-Escámez, researcher in charge of the Biohealth Research Institute in Granada (ibs.GRANADA)—has identified new genes associated with familial Meniere's disease.

1 Dec 2021

Study shows long-term safety and biologic activity of golodirsen in DMD patients

This first-in-human study of golodirsen showed its long-term safety and biologic activity in patients with Duchenne Muscular Dystrophy (DMD). The approved exon-skipping therapy is designed to enable the production of functional dystrophin proteins, as described in the peer-reviewed journal Nucleic Acid Therapeutics.

1 Dec 2021

Comparison of peptides from human cardiac proteins and SARS-CoV-2 proteins

A new study investigated whether linear peptides contained in proteins (primarily expressed in the heart) also occur in the SARS-CoV-2 proteome.

1 Dec 2021

Study sheds light on Aβ deposition patterns in the brain from external sources

Alzheimer's disease (AD) involves the deposition of a protein called amyloid β protein (Aβ) in the brain. This protein can build up in both the functional tissues, or "parenchyma", of the brain, and in the blood vessels.

30 Nov 2021

Nanoengineers develop a new approach to effectively deliver mRNA into cells

Nanoengineers at the University of California San Diego have developed a new and potentially more effective way to deliver messenger RNA (mRNA) into cells.

30 Nov 2021

An antiviral regimen based on biomimetic polymers for COVID-19

In a new study published on the bioRxiv* preprint server, scientists proposed the aforementioned mechanism of action (MOA) and have validated it using electron photomicrographs of murine cytomegalovirus (MCMV), which were incubated with a nanoviricide.

30 Nov 2021

Protein C News and Research

Deactivating the cancer-causing protein by cutting off other proteins that activate it

Fourth shot of Moderna COVID vaccine improves Delta variant neutralization in kidney transplant patients

Fast-tracked human stroke drug may also be a safe and powerful defense against dementia

Neural network 'hallucinates' proteins with new, stable structures

Structure function analysis of potent antibodies against Beta SARS-CoV-2 variant

Plant-derived virus-like particle vaccines against SARS-CoV-2

DNA sequencing of residual disease accurately identifies leukemia patients who would relapse

Impact of SARS-CoV-2 on oral health

Role of interferon type I-driven responses associated with disease control in COVID-19

Novel nanopore technique for annotation of SARS-CoV-2 capping sites and understanding sgRNA structure

Scientists identify new genes associated with familial Meniere's disease

Study shows long-term safety and biologic activity of golodirsen in DMD patients

Comparison of peptides from human cardiac proteins and SARS-CoV-2 proteins

Study sheds light on Aβ deposition patterns in the brain from external sources

Nanoengineers develop a new approach to effectively deliver mRNA into cells

An antiviral regimen based on biomimetic polymers for COVID-19

'Biosensor barcodes' can identify and track how cancer cells 'talk' to each other

New combination treatment enables complete tumor regression in mice with high-risk neuroblastoma

Virginia Tech researchers discover potential target for diagnosing and treating Lyme disease

Omicron and other coronavirus variants: What you need to know

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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