Antigen News and Research

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The antimicrobial potential of nanoparticles

Nanoparticles have widely been used as advanced tools for the diagnosis, prevention, and treatment of infectious diseases.

23 May 2023

Heart transplants from COVID-19 donors: Mixed outcomes revealed in early analysis

In a recent study published in the Journal of the American College of Cardiology, researchers investigated coronavirus disease 2019 (COVID-19)-infected donor use, donor and recipient characteristics, and early post-heart transplantation (HT) outcomes in the United States (US).

23 May 2023

Cross-reactivity between Epstein-Barr virus and protein in multiple sclerosis sheds light on disease development

Research uncovers the association between multiple sclerosis (MS) and antibody reactivity to specific amino acids in CRYAB, along with the increased risk when combined with high EBNA1 responses. The study provides evidence of antibody and T cell cross-reactivity between EBNA1 and CRYAB, highlighting the role of EBV adaptive immune responses in MS development.

21 May 2023

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Research describes the development of a synthetic delivery vector called STxB for mucosal vaccination. It induces mucosal immunity, including resident memory CD8+ T cells and IgA antibodies, against antigens derived from mucosal viruses when administered intranasally in mice.

21 May 2023

Mouse study offers clues to developing an effective vaccine for Klebsiella bacteria

A mouse study at Washington University School of Medicine in St. Louis points to data that could be key to developing an effective vaccine for the bacterium Klebsiella pneumoniae.

18 May 2023

Shared decision policies lead to high rates of PSA testing and inequity with minimal benefit

Most high income countries, including the UK, do not have a national prostate cancer screening programme, but instead allow men without symptoms to get a prostate-specific antigen (PSA) test if they wish, after talking to their doctor.

18 May 2023

Novel computational platform can expand the pool of cancer immunotherapy targets

Researchers at Children's Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, expanding the pool of cancer immunotherapy targets.

17 May 2023

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

Researchers generated six human monoclonal antibodies that prevented infection.

17 May 2023

Study establishes a mechanistic link between obesity and oral cancer immune escape

A team from the University of Michigan Rogel Cancer Center and School of Dentistry, led by Yu Leo Lei, D.D.S., Ph.D., have identified a mechanism in mice for how obesity affects some oral cancers' ability to escape from the immune system.

16 May 2023

PhenomeX Launches Beacon Select™ Optofluidic System with Opto® B Discovery Workflows

Affordable two-chip Beacon Select system to broaden customer access to innovative high throughput, function-first antibody discovery capabilities.

From Bruker Cellular Analysis 16 May 2023

LabGenius Debuts T-cell Engager Optimisation Capability That Yields Molecules with >400-fold Tumour Killing Selectivity Versus Clinical Benchmark

Through a recent platform demonstration project, LabGenius’ machine learning-driven lead optimisation capability delivered dozens of novel T-cell engagers with best-in-class killing selectivity.

From LabGenius 16 May 2023

Insights from blood donors: Serosurveillance reveals population insights for targeted health interventions

Research highlights the effectiveness of serosurveillance in monitoring SARS-CoV-2 exposure within a population. It emphasizes the importance of considering demographic variations in antibody prevalence to inform targeted public health strategies.

16 May 2023

Does obstructive sleep apnea increase the risk of post-acute sequelae of SARS-CoV-2?

Research paper examines the potential link between obstructive sleep apnea (OSA) and Post-Acute Sequelae of SARS-CoV-2 (PASC), the long-term effects of COVID-19. It investigates whether OSA increases the risk of more severe PASC outcomes.

15 May 2023

Phase 1 clinical trial of CAR-NKT cell therapy shows promising results in neuroblastoma patients

Researchers at Baylor College of Medicine/Texas Children's Cancer Center and collaborating institutions report interim results from a first-in-human phase 1 clinical trial evaluating the safety, antitumor activity and immunological characteristics of a genetically engineered natural killer T (NKT) cell immunotherapy for neuroblastoma, a childhood tumor that most commonly arises in the adrenal gland.

15 May 2023

Antigen News and Research

The antimicrobial potential of nanoparticles

Heart transplants from COVID-19 donors: Mixed outcomes revealed in early analysis

Cross-reactivity between Epstein-Barr virus and protein in multiple sclerosis sheds light on disease development

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Mouse study offers clues to developing an effective vaccine for Klebsiella bacteria

Shared decision policies lead to high rates of PSA testing and inequity with minimal benefit

Novel computational platform can expand the pool of cancer immunotherapy targets

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

Study establishes a mechanistic link between obesity and oral cancer immune escape

PhenomeX Launches Beacon Select™ Optofluidic System with Opto® B Discovery Workflows

LabGenius Debuts T-cell Engager Optimisation Capability That Yields Molecules with >400-fold Tumour Killing Selectivity Versus Clinical Benchmark

Insights from blood donors: Serosurveillance reveals population insights for targeted health interventions

Does obstructive sleep apnea increase the risk of post-acute sequelae of SARS-CoV-2?

Phase 1 clinical trial of CAR-NKT cell therapy shows promising results in neuroblastoma patients

Study identifies extremely potent monoclonal antibodies that neutralized multiple sarbecoviruses

New SNAP approach to customizing T cell-based immunotherapies

Upregulated expression of many LY6 genes linked to poor survival in endometrial cancer patients

Cancer-fighting immune cells can fuel their ability to attack tumors

Did race/ethnicity disparities in severe COVID-19 outcomes persist in the era of vaccination?

Study pinpoints how gut microbes boost the body's response to cancer immunotherapy

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