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Receptor structure-based virtual screening identifies a promising p38α inhibitor

Announcing a new publication for Acta Materia Medica journal. Mitogen-activated protein kinases (MAPKs) are a group of serine-threonine protein kinases that can be activated by extracellular stimuli.

27 Oct 2023

AI-designed drug candidate shows promise for gastric acid inhibition

Researchers at Nagoya University in Japan created and improved artificial intelligence (AI) designs to synthesize a candidate compound for a new gastric acid inhibitor with a better binding affinity than existing drugs.

26 Oct 2023

New study challenges long-held belief about how chemotherapy works

A new study from the University of Wisconsin–Madison suggests that chemotherapy may not be reaching its full potential, in part because researchers and doctors have long misunderstood how some of the most common cancer drugs actually ward off tumors.

26 Oct 2023

Somatic mutations in the skin not responsible for the start or spread of psoriasis

Psoriasis - a chronic skin condition - is not caused or spread by spontaneous genetic mutations in the skin, new research suggests.

26 Oct 2023

In acute myocardial infarction patients, does adding a traditional Chinese medicine compound to standard treatments improve outcomes?

Researchers investigated whether Tongxinluo, a Chinese medicinal compound, could improve clinical outcomes among ST-segment elevation myocardial infarction patients.

26 Oct 2023

Newly identified small molecule can suppress growth of breast and ovarian cancers in animal models

Researchers at Baylor College of Medicine have identified a small molecule named 5D4 that can suppress the growth of breast and ovarian cancers in animal models.

25 Oct 2023

Scientists develop new method to control brain activity with light

Studying the brain remains one of the most challenging endeavors in neuroscience. Researchers have explored various methods for live imaging and stimulation of deep brain activity.

25 Oct 2023

Marijuana's psychoactive compound may alter brain wiring in adolescents

In a mouse study designed to explore the impact of marijuana's major psychoactive compound, THC, on teenage brains, Johns Hopkins Medicine researchers say they found changes to the structure of microglia, which are specialized brain immune cells, that may worsen a genetic predisposition to schizophrenia.

25 Oct 2023

Could duck fats be a healthier alternative to saturated fats?

A recent study explores the potential benefits of utilizing duck fats in the food industry, highlighting their unique fatty acid composition and improved properties compared to vegetable oils. Duck fats offer a healthier alternative to saturated fats, making them a valuable resource for enhancing food products.

22 Oct 2023

Low serotonin levels observed in long COVID and other viral infections

Researchers identify a pathophysiological mechanism linking serotonin reduction to the multifaceted etiology of post-acute sequelae of COVID-19.

20 Oct 2023

Potato starch supplement may help prevent gvhd in bone marrow transplant patients

Researchers at Baylor College of Medicine and the University of Michigan conducted a phase I pilot study to assess the feasibility of using potato starch as a dietary intervention to modify the gut microbiome in bone marrow transplant patients.

19 Oct 2023

MuTaLig: A multi-target paradigm for innovative drug discoveries

Everyone at some point in their life may need to take medication to treat an illness or disease. By finding new and better ways to create drugs, the COST Action Multi-target paradigm for innovative ligand identification in the drug discovery process (MuTaLig) helped improve the effectiveness and safety of the medications, which can ultimately benefit people's health and well-being.

19 Oct 2023

Virginia Tech researchers develop new drug design framework to fight COVID-19

As the COVID-19 pandemic scattered and isolated people, researchers across Virginia Tech connected for a data-driven collaboration seeking improved drugs to fight the disease and potentially many other illnesses.

19 Oct 2023

Abortion coverage is limited or unavailable at a quarter of large employers, KFF survey finds

About a quarter of large U.S. employers heavily restrict coverage of legal abortions or don't cover them at all under health plans for their workers, according to the latest employer health benefits survey by KFF.

18 Oct 2023

Researchers receive NCI grant for the development of new pancreatic cancer therapies

Researchers at Washington University School of Medicine in St. Louis have received an NCI grant that will provide about $10.9 million to research programs for the development of new therapies for pancreatic ductal adenocarcinoma, the deadliest form of pancreatic cancer.

17 Oct 2023

SwRI develops unique technology for safe and efficient synthesis of OPNA oxime antidotes

Southwest Research Institute has developed a unique technology (US20230242487A1) that enables the safe and efficient synthesis of organophosphorus nerve agent (OPNA) oxime antidotes.

17 Oct 2023

Biochemists reveal how to prevent cancer cells from becoming resistant to chemotherapy

Biochemists from RUDN University described how to prevent cancer cells from becoming resistant to chemotherapy drugs.

16 Oct 2023

Aureane-type sesquiterpene tetraketides hold great promise in treating IL-17A-mediated immune diseases

This new article publication from Acta Pharmaceutica Sinica B, discusses aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity.

15 Oct 2023

New TB treatments tackle the disease without wrecking your microbiome

Researchers in a study published in The Lancet Microbe examined how various tuberculosis treatment regimens affect the respiratory microbiome. They found that certain treatments control tuberculosis effectively while minimally impacting the diversity and health of the respiratory microbiome.

15 Oct 2023

Intracellular journey: The penetration of antidepressants into cells, organelles, and membranes

Researchers in neuropsychopharmacology challenge conventional wisdom about antidepressants' actions, revealing significant intracellular activity that influences their effectiveness. Utilizing advanced technologies, the study prompts a reevaluation of drug targeting and mechanisms, opening new avenues for treating depression.

12 Oct 2023

Compound News and Research

Receptor structure-based virtual screening identifies a promising p38α inhibitor

AI-designed drug candidate shows promise for gastric acid inhibition

New study challenges long-held belief about how chemotherapy works

Somatic mutations in the skin not responsible for the start or spread of psoriasis

In acute myocardial infarction patients, does adding a traditional Chinese medicine compound to standard treatments improve outcomes?

Newly identified small molecule can suppress growth of breast and ovarian cancers in animal models

Scientists develop new method to control brain activity with light

Marijuana's psychoactive compound may alter brain wiring in adolescents

Could duck fats be a healthier alternative to saturated fats?

Low serotonin levels observed in long COVID and other viral infections

Potato starch supplement may help prevent gvhd in bone marrow transplant patients

MuTaLig: A multi-target paradigm for innovative drug discoveries

Virginia Tech researchers develop new drug design framework to fight COVID-19

Abortion coverage is limited or unavailable at a quarter of large employers, KFF survey finds

Researchers receive NCI grant for the development of new pancreatic cancer therapies

SwRI develops unique technology for safe and efficient synthesis of OPNA oxime antidotes

Biochemists reveal how to prevent cancer cells from becoming resistant to chemotherapy

Aureane-type sesquiterpene tetraketides hold great promise in treating IL-17A-mediated immune diseases

New TB treatments tackle the disease without wrecking your microbiome

Intracellular journey: The penetration of antidepressants into cells, organelles, and membranes

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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