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New molecular pathway identified in alcohol-associated liver disease

Excessive alcohol consumption causes alcoholic liver disease, and about 20% of these cases progress to alcohol-associated steatohepatitis (ASH), which can lead to liver cirrhosis and liver failure. Early diagnosis and treatment are therefore extremely important.

17 Jul 2025

New genetic marker improves kidney transplant match predictions

Researchers at the University of Pittsburgh have identified a new way of predicting whether a kidney donor and recipient are a good match for transplantation.

17 Jul 2025

Common medications impact gut microbiome and promote pathogen growth

The human intestine is home to a dense network of microorganisms, known collectively as the gut microbiome, which actively helps to shape our health.

16 Jul 2025

Targeting amino acid networks could lead to more precise medicines

Amino acids play a fundamental role in regulating how cells respond to drugs. These molecules, which form proteins, act like bricks that communicate with each other within a structure.

16 Jul 2025

Shared brain circuit drives opposite mating behaviors in male and female mice

In animals with social structures, the drive to reproduce is a complex process; governed by the brain, it's influenced by both internal cues such as hormones and external factors such as interactions with potential mates.

16 Jul 2025

FAU neuroscientist receives NIH grant to study amphetamine effects on the brain

Lucia Carvelli, Ph.D., associate professor of neuroscience at Florida Atlantic University's Harriet L. Wilkes Honors College and a member of the FAU Stiles-Nicholson Brain Institute, has received a $571,675 grant from the National Institutes of Health to advance critical research into how amphetamines affect brain function.

15 Jul 2025

New cellular entry pathway improves gene therapy outcomes

Scientists from the Centenary Institute and the University of Sydney have made a landmark discovery that could lead to safer and more effective gene therapies for a range of serious genetic disorders including Duchenne muscular dystrophy, Pompe disease and hemophilia.

15 Jul 2025

Visual food cues may lead to overeating even without hunger

Watching others eat tasty foods may lead to overeating, even in the absence of hunger, according to a new mouse study being presented Monday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

14 Jul 2025

Early-career physician-scientists receive major support from Damon Runyon Cancer Research Foundation

The Damon Runyon Cancer Research Foundation has named five new Damon Runyon Clinical Investigators.

14 Jul 2025

New immunotherapy targets leukemia at its root

Researchers at MUSC Hollings Cancer Center have identified a signaling loop involved in the growth and persistence of leukemia cells – and developed a novel immunotherapy that can disrupt that loop to boost immune function and improve survival.

14 Jul 2025

EAGLE model predicts key lung cancer mutations from routine biopsy

With EAGLE, lung cancer biopsy analysis is expedited, accurately predicting EGFR mutations and streamlining the diagnostic process for better patient outcomes.

14 Jul 2025

Melatonin receptor signaling counters sleep fragmentation-mediated infertility in T2DM

This new article publication from Acta Pharmaceutica Sinica B, discusses how melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.

12 Jul 2025

Osteoblast estrogen receptor signaling found essential for bone integrity

Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen receptor alpha (mERα) signaling in specific cell types of female mice affects bone health.

12 Jul 2025

Teclistamab shows promising results in heavily pretreated multiple myeloma

Teclistamab-cqyv (Tecvayli) led to clinically meaningful responses in patients with heavily pretreated multiple myeloma who would have been ineligible for the MajesTEC-1 trial, and identified a novel factor independently associated with outcomes.

12 Jul 2025

Scientists identify key role of T-bet in flu memory B cells

At the surface, the immune response to a flu virus is simple. Some cells recognize the pathogen and send a signal to the immune system, and immune cells produce a potentially lifesaving antibody against the virus. Antigen in, antibody out.

11 Jul 2025

Fasting triggers neuroprotective changes that could delay dementia

Intermittent fasting could be a neuroprotective strategy, improving gut-brain axis function and reducing inflammation linked to neurodegenerative diseases.

11 Jul 2025

Understanding resistance to EGFR targeted therapies in head and neck cancers and breast cancer

A new review was published in Volume 16 of Oncotarget on June 25, 2025, titled "Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms."

10 Jul 2025

Psychological stress drives ovarian tumor metastasis through NR3C1 and NUPR1

This new article publication from Acta Pharmaceutica Sinica B, discusses how a psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis.

10 Jul 2025

New analysis shows stopping antidepressants rarely leads to severe symptoms

The largest review of 'gold standard' antidepressant withdrawal studies to date has identified the type and incidence of symptoms experienced by people discontinuing antidepressants, finding most people do not experience severe withdrawal.

10 Jul 2025

Slower speech response linked to sleepiness in older adults

A new study led by UCLA investigators shows that Verbal Reaction Time (VRT), the amount of time it takes a person to respond verbally, can be a marker of sleepiness in older adults.

9 Jul 2025