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Customary drug dose for treatment of lung cancer may be higher than needed, study shows

A new study published in the Journal of the National Cancer Institute indicates that the customary pembrolizumab dose for treatment of metastatic non-small cell lung cancer may be higher than is needed for effective treatment.

6 Jun 2017

New immunotherapy sends multiple myeloma into remission

Researchers are reporting the impressive results of a new cell and gene therapy that has achieved unprecedented success in treating multiple myeloma patients. Although the study is an early one and the population only included 35 people, every one of the patients responded to the treatment and 33 (94%) were in some degree of clinical remission within two months.

6 Jun 2017

Older people with persistent pain more likely to develop dementia

Researchers at UC San Francisco have found that older people with persistent pain show quicker declines in memory as they age and are more likely to have dementia years later, an indication that chronic pain could somehow be related to changes in the brain that contribute to dementia.

5 Jun 2017

Novartis, Bristol-Myers Squibb collaborate to examine combination therapies for metastatic colorectal cancer

Novartis today announced it has entered into a clinical research collaboration in which Bristol-Myers Squibb will investigate the safety, tolerability, and efficacy of Mekinist (trametinib) in combination with Opdivo (nivolumab) and Opdivo + Yervoy (ipilimumab) regimen as a potential treatment option for metastatic colorectal cancer in patients with microsatellite stable tumors where the tumors are proficient in mismatch repair (MSS mCRC pMMR).

5 Jun 2017

EFMT technology results in greater reduction of major depressive disorder symptoms

A treatment for depression using Emotional Faces Memory Task (EFMT), a technology originally developed by two Mount Sinai researchers, resulted in a significantly greater reduction of major depressive disorder (MDD) symptoms compared to a control group, according to initial clinical results presented at the Society of Biological Psychiatry Annual Scientific Convention on May 19, 2017, in San Diego.

5 Jun 2017

Online intervention can relieve distress, improve quality of life for cancer patients

Most patients experience significant distress after they are diagnosed with cancer. This distress not only erodes quality of life, but can also negatively affect the course of the disease and the patient's ability to tolerate treatment.

5 Jun 2017

New targeted oral therapy results in durable responses across many kinds of cancer

Scientists may have developed the first targeted, oral, tumor-type agnostic therapy - a cancer medicine that works comparably well across many kinds of cancer, regardless of patient age. In clinical trials of adults and children with 17 different types of advanced cancer, larotrectinib treatment resulted in responses in 76% of patients.

5 Jun 2017

Immunotherapy combination offers new hope for women with early stage triple negative breast cancer

A Yale Cancer Center clinical trial combining the immune checkpoint inhibitor (durvalumab/MEDI4736) with chemotherapy as preoperative treatment for early stage triple negative breast cancer disclosed a 71% pathologic complete response to the combination treatment in the initial phase I trial.

2 Jun 2017

Assessing safety and toxicity of bioactives could be key to establishing tolerable upper intake levels

The good news is out that wine and dark chocolate may be good for your health. That's because of substances known as bioactives that are contained in those foods.

2 Jun 2017

Scientists discover unexpected mechanism behind chronic nerve pain

It has long been assumed that chronic nerve pain is caused by hypersensitivity in the neurons that transmit pain.

1 Jun 2017

TMS therapy offers hope for senior adults with depression

Late-life depression (LLD) is a frequent complication of the aging process, occurring in up to 5% of senior adults and in a higher proportion of subjects with coexistent medical illnesses.

1 Jun 2017

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Combining the kinase inhibitor ibrutinib with an investigational personalized cellular therapy known as CTL119 can lead to complete remission in patients with high-risk chronic lymphocytic leukemia (CLL), according to new research from the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center

31 May 2017

TB germs' metabolic 'escape pathways' may be neutralized by new drugs to shorten duration of therapy

New research suggests the bacteria that cause tuberculosis alter their metabolism to combat exposure to antimicrobials, and that these metabolic "escape pathways" might be neutralized by new drugs to shorten the troublesome duration of therapy.

31 May 2017

Oxytocin treatment may help overcome drug addiction, study suggests

Many people have suggested that addiction hijacks the body's natural drives in the service of compulsive drug use.

31 May 2017

New handheld tissue scanner allows looking under the skin of psoriasis patients

A newly developed tissue scanner allows looking under the skin of psoriasis patients. This provides clinically relevant information, such as the structure of skin layers and blood vessels, without the need for contrast agents or radiation exposure.

31 May 2017

Radboudumc, iMM Lisboa, PATH team up to test new malaria vaccine concept

The Radboud University Medical Center in the Netherlands, the Instituto de Medicina Molecular Lisboa in Portugal, and PATH in Seattle, Washington announced today that they will collaborate to test a new approach to malaria vaccine development in humans for the first time.

31 May 2017

Fixed-dose combination therapy for high blood pressure linked to lower health services costs

About half of patients diagnosed with high blood pressure will need their medication adjusted within the first year to address side effects or failure to control blood pressure properly.

30 May 2017

Amped up antibiotic to fight resistant bacteria finally a reality

Resistant bacteria have been a menace killing thousands worldwide. Bacteria causing pneumonia, tuberculosis, wound and skin infections, gonorrhea have notably undergone major changes to evade the current armament of antibiotics that physicians have to fight them with.

30 May 2017

Heartbeat-like vibration from new wearable device can reduce stress

New research published in Scientific Reports shows that a heartbeat-like vibration delivered onto the inside of the wrist can make the wearer feel significantly less stressed.

30 May 2017

Dual therapy effective as second-line treatment for patients infected by HIV with multiple mutations

ANRS 12286 MOBIDIP, a clinical trial running in parallel in three countries in sub-Saharan Africa (Cameroon, Burkina Faso, and Senegal), shows that dual therapy with lamivudine and a boosted protease inhibitor is effective as second-line treatment in patients infected by HIV with multiple mutations.

29 May 2017

Efficacy News and Research

Customary drug dose for treatment of lung cancer may be higher than needed, study shows

New immunotherapy sends multiple myeloma into remission

Older people with persistent pain more likely to develop dementia

Novartis, Bristol-Myers Squibb collaborate to examine combination therapies for metastatic colorectal cancer

EFMT technology results in greater reduction of major depressive disorder symptoms

Online intervention can relieve distress, improve quality of life for cancer patients

New targeted oral therapy results in durable responses across many kinds of cancer

Immunotherapy combination offers new hope for women with early stage triple negative breast cancer

Assessing safety and toxicity of bioactives could be key to establishing tolerable upper intake levels

Scientists discover unexpected mechanism behind chronic nerve pain

TMS therapy offers hope for senior adults with depression

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

TB germs' metabolic 'escape pathways' may be neutralized by new drugs to shorten duration of therapy

Oxytocin treatment may help overcome drug addiction, study suggests

New handheld tissue scanner allows looking under the skin of psoriasis patients

Radboudumc, iMM Lisboa, PATH team up to test new malaria vaccine concept

Fixed-dose combination therapy for high blood pressure linked to lower health services costs

Amped up antibiotic to fight resistant bacteria finally a reality

Heartbeat-like vibration from new wearable device can reduce stress

Dual therapy effective as second-line treatment for patients infected by HIV with multiple mutations

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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