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Efficacy of polymeric nano-micelles depends on expression level of c-Myc

The Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki in Japan, Abbreviation: iCONM) reported in ACS Nano (Impact Factor: 14.588 in 2019) together with the group of Prof. Yu Matsumoto of Otorhinolaryngology and Head and Neck Surgery (Prof. Tatsuya Yamasoba) and the group of Prof. Horacio Cabral of the Department of Bioengineering (Prof. Ryo Miyake) in the University of Tokyo that the efficacy of polymeric nano-micelles with different drug activation profile depends on the expression level of c-Myc, one of the major proto-oncogene, has been developed.

27 Feb 2021

Study on artificial microswimmers could improve the efficacy of targeted cancer therapy

A Mason Engineering researcher has discovered that artificial microswimmers accumulate where their speed is minimized, an idea that could have implications for improving the efficacy of targeted cancer therapy.

27 Feb 2021

FDA to finalize the issuance of emergency use authorization for vaccine distribution

Following today's positive advisory committee meeting outcome regarding the Janssen Biotech Inc. COVID-19 Vaccine, the U.S. Food and Drug Administration has informed the sponsor that it will rapidly work toward finalization and issuance of an emergency use authorization.

27 Feb 2021

FDA approves Nulibry to reduce risk of death caused by rare genetic, metabolic disorder

Today, the U.S. Food and Drug Administration approved Nulibry (fosdenopterin) for injection to reduce the risk of death due to Molybdenum Cofactor Deficiency Type A, a rare, genetic, metabolic disorder that typically presents in the first few days of life, causing intractable seizures, brain injury and death.

27 Feb 2021

FDA undertakes new action in its ongoing response effort to COVID-19 pandemic

The U.S. Food and Drug Administration today announced the following actions taken in its ongoing response effort to the COVID-19 pandemic:

27 Feb 2021

Scientists develop a simple method to make drug precursor

Save your silver! It's better used for jewelry than as a catalyst for drugs. Rice University scientists have developed a greatly simplified method to make fluoroketones, precursors for drug design and manufacture that typically require a silver catalyst.

27 Feb 2021

Study: Heart problems cause disturbed gene activity in the brain's memory center

Heart problems cause disturbed gene activity in the brain's memory center, from which cognitive deficits arise.

27 Feb 2021

Neanderthal-derived protein may protect against COVID-19 susceptibility and severity

Researchers at the Lady Davis Institute at the Jewish General Hospital have discovered that increased levels of the protein OAS1 are associated with reduced mortality and less severe disease requiring ventilation among patients with COVID-19.

26 Feb 2021

Biomarkers in the blood can predict severe outcomes in COVID-19 patients

When patients with COVID-19 arrive in emergency rooms, there are relatively few ways for doctors to predict which ones are more likely to become critically ill and require intensive care and which ones are more likely to enjoy a quick recovery.

26 Feb 2021

Repurposed drugs show antiviral SARS-CoV-2 E channel blocking activity, finds study

A new study by researchers at The Hebrew University of Jerusalem in Israel reports the discovery of a promising group of E channel inhibitors with significant antiviral activity. This could be developed into new treatment agents for this often-deadly virus.

26 Feb 2021

New 'E-Morph' test method replaces animal experiments to detect hormone-like effects

Endocrine disruptors (EDs) are hormone-like substances that can have undesirable effects on health. For example, chemicals can increase the risk of breast cancer if they act in a manner similar to the female sex hormone estrogen.

26 Feb 2021

FDA permits marketing of new device to protect athletes from harmful effects of head impacts

Today, the U.S. Food and Drug Administration authorized marketing of a new device intended to be worn around the neck of athletes aged 13 years and older during sports activities to aid in the protection of the brain from the effects associated with repetitive sub-concussive head impacts.

26 Feb 2021

Biden’s straight-talking CDC director has long used data to save lives

In early December, Dr. Katy Stephenson was watching TV with her family and scrolling through Twitter when she saw a tweet that made her shout.

26 Feb 2021

Catalent to Acquire Delphi Genetics and Launch US Plasmid Manufacturing Site to Establish Global pDNA Development and Manufacturing Capabilities

Catalent and Delphi Genetics today announced that they have entered into a final and definitive agreement whereby Catalent will acquire 100% of the shares of Delphi Genetics.

26 Feb 2021

Catalent to Acquire Delphi Genetics and Launch US Plasmid Manufacturing Site to Establish Global pDNA Development and Manufacturing Capabilities

Catalent and Delphi Genetics today announced that they have entered into a final and definitive agreement whereby Catalent will acquire 100% of the shares of Delphi Genetics.

26 Feb 2021

New device accelerates transdermal penetration of drug molecules and extraction of interstitial fluid

A pain-free, organic and biodegradable drug delivery patch may be on the horizon for home health care patients soon.

26 Feb 2021

New approach harnesses disease-causing proteins to combat cancer

Over many decades now, traditional drug discovery methods have steadily improved at keeping diseases at bay and cancer in remission. And for the most part, it's worked well.

26 Feb 2021

FDA allows flexible storage and transportation conditions for Pfizer-Biontech COVID-19 vaccine

Today, the U.S. Food and Drug Administration announced that it is allowing undiluted frozen vials of the Pfizer-BioNTech COVID-19 Vaccine to be transported and stored at conventional temperatures commonly found in pharmaceutical freezers for a period of up to two weeks.

26 Feb 2021

Extensive use of opioid agonists can considerably reduce drug-related deaths

New evidence that opioid agonists such as methadone and buprenorphine could substantially reduce drug-related deaths if more widely used in the community and prison, and for longer, has been published in Lancet Psychiatry.

25 Feb 2021

Scientists receive grant to investigate tumor development within a natural environment

Unlike many of us during the COVID-19 pandemic, biological cells are not isolated from the outside world. Chemical variations, intercellular activity, and other microenvironmental factors impact cell survival.

25 Feb 2021

Drugs News and Research

Efficacy of polymeric nano-micelles depends on expression level of c-Myc

Study on artificial microswimmers could improve the efficacy of targeted cancer therapy

FDA to finalize the issuance of emergency use authorization for vaccine distribution

FDA approves Nulibry to reduce risk of death caused by rare genetic, metabolic disorder

FDA undertakes new action in its ongoing response effort to COVID-19 pandemic

Scientists develop a simple method to make drug precursor

Study: Heart problems cause disturbed gene activity in the brain's memory center

Neanderthal-derived protein may protect against COVID-19 susceptibility and severity

Biomarkers in the blood can predict severe outcomes in COVID-19 patients

Repurposed drugs show antiviral SARS-CoV-2 E channel blocking activity, finds study

New 'E-Morph' test method replaces animal experiments to detect hormone-like effects

FDA permits marketing of new device to protect athletes from harmful effects of head impacts

Biden’s straight-talking CDC director has long used data to save lives

Catalent to Acquire Delphi Genetics and Launch US Plasmid Manufacturing Site to Establish Global pDNA Development and Manufacturing Capabilities

Catalent to Acquire Delphi Genetics and Launch US Plasmid Manufacturing Site to Establish Global pDNA Development and Manufacturing Capabilities

New device accelerates transdermal penetration of drug molecules and extraction of interstitial fluid

New approach harnesses disease-causing proteins to combat cancer

FDA allows flexible storage and transportation conditions for Pfizer-Biontech COVID-19 vaccine

Extensive use of opioid agonists can considerably reduce drug-related deaths

Scientists receive grant to investigate tumor development within a natural environment

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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